ISSN:
1600-0714
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Lobular capillary hemangioma (LCH) usually occurs in the skin or mucous membranes as a rapidly growing red nodule. LCH is one of the most common vascular lesions in the oral mucosa. Tie2 is a novel, human endothelial receptor tyrosine kinase which may play an important role in blood vessel formation. In this study, we investigated its immunohistochemical expression in LCH of the oral mucosa.Methods: Double immunostaining with anti-CD34 and antiα smooth muscle actin (SMA) antibodies was performed to characterize the cellular expression of Tie2 in 15 cases of this condition.Results: We found Tie2 immunoreactivity in the ovoid cells only, which were frequently intermingled with αSMA-positive cells, especially in the hypercellular portion of LCH.Conclusions: These results suggest that the expression of Tie2 in ovoid cells and the interaction between ovoid cells and αSMA-positive cells play an important part in the development and progression of LCH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-0714.2002.310708.x
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