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  • 1
    Electronic Resource
    Electronic Resource
    The function of polyglyceryl erucate/isostearate/ricinoleate (2004)
    Oxford, UK : Blackwell Science Ltd
    International journal of cosmetic science 26 (2004), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Today, it is said that the formula design of cosmetics from ingredients of plant origin is an indispensable way and trend. From this consideration, cosmetic materials made from animal and synthetic petroleum ingredients are becoming less usable. Instead, cosmetic materials are designed from ingredients of plant origin and many and various botanical ingredients are being developed. Lanolin, which is one of the animal-based ingredients, is said to have ideal functions as a cosmetic oil, and it has been used in many fields such as make-up cosmetics as well as hair and skin care products for a long time. However, unfortunately, lanolin is an animal-based ingredient; therefore, the development of a botanical ingredient to replace lanolin was desired. Polyglyceryl-8 decaerucate/isostearate/ricinoleate, which we have developed, is an ester oil originating from plants and has an equivalent or higher function than lanolin. We have confirmed that our developed ester oil has various excellent characteristics such as a water-holding capability 2.5 times higher than that of lanolin, high air permeability, moisture keeping in dermal layers, protection of hair from changes in external environmental humidity, and excellent gloss and excellent dispersability of pigments. Thus, this newly developed ester oil is expected to be a promising new botanical cosmetic ingredient which can be applied in various fields.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-2494.2004.00231_2.x
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  • 2
    Electronic Resource
    Electronic Resource
    Novel dinucleotide repeat polymorphism in the first exon of the STAT-6 gene is associated with allergic diseases (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background T helper-type 2 cytokines, such as interleukin-4 (IL-4) and IL-13, may play a central role in allergic diseases. The protein known as ‘signal transducers and activators of transcription 6’ (STAT-6) is a key transcription factor involved in both IL-4- and IL-13-mediated biological responses.Objective The objective of this study was to evaluate the possible role of the STAT-6 gene in modulating atopy in the Japanese population.Methods We screened all 23 exons of the STAT-6 gene from 10 subjects for mutations by direct polymerase chain reaction (PCR) sequencing. The STAT-6 gene polymorphisms were genotyped by PCR fragment length polymorphism analysis and PCR-SSCP analysis. The IL-4 receptor Q576R polymorphism was also examined by PCR-SSCP analysis.Results We found a novel dinucleotide repeat polymorphism in the first exon of the STAT-6 gene. The genotypes were classified into four groups according to the number of GT repeats present, from 13 to 16. The frequency of the A1 allele (326 bp, containing 13 repeats of GT) was higher in children with allergic diseases (bronchial asthma, atopic dermatitis and/or food-related anaphylaxis) than controls, although this was not statistically significant (P = 0.0158). In addition, a strong association between the A1 and A3 allele (containing 15 repeats of GT) heterozygote and allergic diseases was identified (P = 0.0002). However, the levels of IgE were not related to the GT repeat polymorphism in the allergic subjects. The GT repeat polymorphism was not associated with the polymorphism in the IL-4 receptorachain gene (Q576R) and there was no association between the G2964A variant and allergic diseases.Conclusion This suggests that genetic variation in the STAT-6 gene may be associated with predisposition to allergic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01191.x
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  • 3
    Electronic Resource
    Electronic Resource
    Familial adenomatous polyposis associated with colon carcinoma, desmoid tumour, gallbladder carcinoma, and endometrioid carcinoma: a case report (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01888.x
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  • 4
    Electronic Resource
    Electronic Resource
    Systematic examination of carrier polarity in composition spread ZnO thin films codoped with Ga and N (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 81 (2002), S. 235-237 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have grown high-crystallinity ZnO thin films on lattice-matched ScAlMgO4 substrates by pulsed-laser deposition with doping donor (Ga) and acceptor (N) simultaneously. Alternating ablation of ceramics with concentrated Ga addition and highly pure single crystal targets yielded in a controlled Ga concentration (CGa) in a wide range of 1018–1020 cm−3 with minimal contamination of undesired impurities such as Al and Si. The use of the originally developed temperature-gradient method, where controlled and continuous gradient of the growth temperature is given to the single substrate with a range of about 50–200 °C, results in a continuous spread of N concentration (CN) in a controlled fashion. Therefore, the ratio of CN/CGa can be varied continuously in a wide range for each film, assuring that a region satisfying p-type codoping condition predicted by T. Yamamoto and H. K. Yoshida [Jpn. J. Appl. Phys., Part 2 38, L166 (1999)] is included in the sample. The electrical properties were measured for over thousand specimens of lithographically patterned Hall bars without observing any sign of p-type conduction. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1491294
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  • 5
    Electronic Resource
    Electronic Resource
    Room-temperature stimulated emission of excitons in ZnO/(Mg, Zn)O superlattices (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 2204-2206 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report on the observation of stimulated emission in ZnO/MgxZn1−xO superlattices well above room temperature. Two kinds of superlattices grown by laser molecular-beam epitaxy showed clear systematics on the quantum subband levels in absorption and spontaneous emission spectra. Stimulated emission with excitonic origin could be observed at very low optical pumping levels. The threshold excitation intensity changed from 11 to 40 kW/cm2, and the emission energy could be tuned between 3.2 and 3.4 eV, depending on the well thickness and/or the Mg content in the barrier layers. The excitonic stimulated emission could be observed up to 373 K and the characteristic temperature was as high as 87 K. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1315340
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  • 6
    Electronic Resource
    Electronic Resource
    Successful eradication of Helicobacter pylori prevents relapse of peptic ulcer disease (2002)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The NIH consensus conference in 1994 recommended that all patients with peptic ulcers should be tested and treated for Helicobacter pylori. Recent studies have shown that the eradication of H. pylori is associated with a significant reduction in the relapse rate of peptic ulcers, but there are few reports about long-term outcome.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To evaluate the relapse rate of peptic ulcer in the long-term follow-up of patients after H. pylori eradication therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Patients and methods:Patients infected with H. pylori (445; 88 duodenal ulcer, 357 gastric ulcer) were randomly divided into three groups. In group A, patients received `conventional treatment' including acid decreasing therapy with a histamine H2-receptor antagonist or proton pump inhibitor (PPI). In group B, patients received `dual therapy' including one antibiotic plus acid-decreasing therapy. In group C, patients received `triple therapy' with PPI plus amoxicillin and clarithromycin. Eradication of H. pylori infection was assessed by histology of biopsy specimens from both the antrum and body corpus at 4 weeks, and 6 and 12 months after stopping therapy. Endoscopy was performed at intervals of 6 months for 5 years.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Intention-to-treat eradication rates for the duodenal ulcer patients were 0% for group A, 46% for group B and 80% for group C; eradication rates for the gastric ulcer patients were 0%, 33% and 83% respectively. No recurrence was noted in the duodenal ulcer patients and only 4% of gastric ulcers recurred after successful eradication during follow-up for 5 years. In contrast, in patients with persistent H. pylori infection all DU and 92% of gastric ulcers recurred.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Eradication of H. pylori infection changes the natural course of peptic ulcer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.16.s2.24.x
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  • 7
    Electronic Resource
    Electronic Resource
    Scleroderma renal crisis with limited cutaneous sclerosis and positive anti-RNA polymerase antibody (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 152-155 
    Details
    ISSN: 1437-7799
    Keywords: Key words Progressive systemic sclerosis ; Scleroderma renal crisis ; Anti-RNA polymerase antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 59-year old Japanese woman diagnosed as having systemic sclerosis with limited cutaneous involvement was hospitalized with scleroderma renal crisis. Malignant hypertension with marked hyperreninemia and grade three hypertensive retinopathy were present, and the renal biopsy showed marked intimal thickening of the small intrarenal arteries. The patient's serum was negative for anticentromere and anti-DNA topoisomerase I (Scl-70) antibodies, whereas a radioimmunoprecipitation study revealed the presence of antibody to RNA polymerases I, II, and III. The patient was successfully treated with captopril, with normalization of blood pressure and reversal of the decreased renal function. The presence of antibody to RNA polymerases may be a marker for the development of life-threatening scleroderma renal crisis even in patients with limited cutaneous systemic sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012168
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  • 8
    Electronic Resource
    Electronic Resource
    Successful resuscitation using nitroglycerin for refractory pulseless electrical activity in intensive care unit (2000)
    Springer
    Intensive care medicine 26 (2000), S. 255-255 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050061
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  • 9
    Electronic Resource
    Electronic Resource
    QT dispersion and Kawasaki disease after coronary bypass surgery (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1009-1009 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051298
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  • 10
    Electronic Resource
    Electronic Resource
    Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene (2000)
    Springer
    Journal of human genetics 45 (2000), S. 294-298 
    Details
    ISSN: 1435-232X
    Keywords: Key words Angiotensin-converting enzyme ; Essential hypertension ; Insertion/deletion ; Polymorphism ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Recent evidence suggests that an insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) is associated with myocardial infarction and related cardiovascular diseases. We investigated a possible association of the ACE polymorphism with essential hypertension in a total of 263 cases/controls from among the elderly (age, over 70 years) and middle-aged (age between 30 and 60 years) Japanese population. The frequency of the I/I homozygote was significantly higher in hypertensive subjects than in controls in the elderly age group (33/57 vs 16/46; P = 0.02), but no association was observed in the middle-aged group (25/75 vs 26/85; P = 0.71). Similarly, having at least one insertion allele was associated with essential hypertension in the elderly age group (83/114 vs 46/92 in controls; P = 0.001), but not in the middle-aged group (78/150 vs 94/170; P = 0.524). These data suggest that genetic variation at the ACE locus may be associated with some determinants for blood pressure in elderly persons, and imply the involvement of the ACE insertion/deletion polymorphism in the etiology of age-related essential hypertension in the Japanese population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070019
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