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  • 2000-2004  (2)
  • 1
    Electronic Resource
    Electronic Resource
    GDNF Induces Recovery of the Nigrostriatal Dopaminergic System in the Rat Brain Following Intracerebroventricular or Intraparenchymal Administration (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 805-810 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Parkinson's disease; GDNF; regeneration; dopamine.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Background. Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a survival and neuroprotective factor for nigrostriatal dopaminergic neurons in vivo. The present study was designed to investigate the possible neuroprotective and restorative role by GDNF for dopaminergic neurons which were exposed to the neurotoxin 6-hydroxydopamine (6-OHDA).  Method. We compared neurochemical, morphological and behavioural changes following striatal infusion of GDNF to those following intracerebroventricular (i.c.v.) infusion.  Findings. Apomorphine-induced rotation showed significant recovery after both types of infusion. Significant recovery of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons and fibers were found in the substantia nigra and striatum following both striatum and i.c.v. infusion except for the number of TH-IR neurons in the i.c.v. infusion group.  Interpretation. These results suggest that GDNF induces recovery of the nigrostriatal dopaminergic system, and this indicates a potential usefulness of GDNF for the treatment of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070096
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Power-law decay of collisionally excited amino acids and quenching by radiative cooling (2003)
    Springer
    The European physical journal 25 (2003), S. 139-148 
    Details
    ISSN: 1434-6079
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We have investigated the time dependence of the fragmentation of protonated amino acids stored at 22 keV in the electrostatic ring ELISA. The ions were produced in an electrospray source and after bunching in a quadrupole trap they were excited by collisions in a Ne gas. As in earlier studies of metal clusters and fullerenes produced in “hot” ion sources we find that the dissociation of metastable molecules follows approximately a 1/t decay law until a time $\tau$ after which the yield falls off much more rapidly. We interpret this reduction as a result of radiative cooling with a characteristic cooling time, $\tau_c \simeq G\tau$ , where G is the magnitude of the exponent in an Arrhenius expression for the rate of the dominant fragmentation process. The values of $\tau$ obtained from fits to the data are in the range 9-17 ms corresponding to cooling times of a few hundred milliseconds, in good accord with the expected rate of cooling by emission from IR-active vibrations. The power-law behaviour for $t 〈 \tau$ varies somewhat between the different amino acids, with powers between -0.9 and -1.1. We argue that this may be due to a competition between fragmentation channels with different Arrhenius parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjd/e2003-00093-9
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    Paper (German National Licenses)
    Fulltext
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