Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The suppression of rat collagen-induced arthritis and inhibition of macrophage derived mediator release by liposomal methotrexate formulations (2000)
    Springer
    Inflammation research 49 (2000), S. 155-161 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Arthritis — Interleukin-1β— Macrophage — Prostaglandin E2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: This study was designed to determine whether liposomes are suitable vehicles for the delivery of methotrexate (MTX-γ-DMPE) for arthritis therapy.¶Material or Subjects: Liposomal formulations containing either egg lecithin (EPC), cholesterol (CHOL) and phosphatidic acid (PA) (MTX-EPC) or distearoylphosphatidylcholine (DSPC), CHOL and distearoylphosphatidylethanolamine conjugated to polyethyleneglycol (PEG) (MTX-PEG) were employed. Rat peritoneal macrophages (rPMφ) were used to test the mechanism of action of these liposomes in vitro, whilst, the rat collagen-induced arthritis (CIA) model was used to evaluate the in vivo efficacy of MTX-EPC and MTX-PEG.¶Treatment: In vitro, rPMφ were incubated with liposomal MTX concentrations ranging from 0 to 15 μg/well. In vivo, rats were given 4 daily intravenous injections of liposomal MTX (2.5 mg/Kg).¶Methods: IL-1β and prostaglandin-E2 (PGE2) release from rPMφ were quantified by immunoradiometric assay. Arthritis progression, in vivo, was measured by serial clinical score and hind paw diameter measurements.¶Results: MTX-EPC and MTX-PEG respectively (15 μg of MTX and 0.15 mg of lipid) were powerful inhibitors of both IL-1β (77 ± 2.3%; 79 ± 4.0%) and PGE2 (75.5 ± 4.9%; 68.5 ± 2.3%) release (mean ± SEM % inhibition) from lipopolysaccaride stimulated rPMφ. In vivo, only MTX-EPC exerted an anti-inflammatory effect, clinical score (p 〈 0.001) and paw diameter (p 〈 0.001) measurements being significantly lower than in control rats, after 2 days treatment.¶Conclusions: MTX-EPC and MTX-PEG are potent inhibitors of pro-inflammatory mediators in vitro, but liposomes with long circulation times do not appear to have therapeutic potential for treating arthritis in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050575
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    What can we learn from traceability in physical measurements? (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 414-417 
    Details
    ISSN: 1432-0517
    Keywords: Key words Traceability ; Physical measurements ; Chemical measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  An international system for providing traceability for the results from physical measurements has been under continuous development since the introduction of the Convention of the Metre over 100 years ago. Such a system has only been in existence for chemical measurements for about a decade and there is much that can be learnt from the way in which traceability has developed in physical measurements that will help its development for chemical measurements. First a number of myths that have grown up about the differences between these are examined. This is followed by a description of examples from physical measurements, which have important lessons for the ways in which traceability for the results of chemical measurements can be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690000218
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Legislative limits below detection capability1 (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 308-313 
    Details
    ISSN: 1432-0517
    Keywords: Key words Detection limit ; Compliance ; Regulation ; Paper and pulp mills
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  A study of contaminant emission data collected for paper and pulp mills in the United Kingdom over a 1-year period is presented. For most sites and analytes, the data could not demonstrate positive compliance with absolute emission limits to water in the 1 g range in large (million tonne) effluent streams, even though some sites were apparently removing contaminants from their water supply. The implications are discussed, with particular reference to the implications of results quoted at 'detection limits' or 'reporting limits'.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690000183
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    EURACHEM – the first 10 years (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 121-123 
    Details
    ISSN: 1432-0517
    Keywords: Key words EURACHEM ; History of EURACHEM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  Part 1 of the history of EURACHEM deals with the development of the initial idea and the early consultations within Europe that led to the definition of its aims and objectives, culminating in its formal establishment in July 1989. This was followed by the signing of the Memorandum of Understanding by 16 countries at the end of 1990. Part 2 describes the subsequent developments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010421
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    EURACHEM – the first 10 years (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 153-155 
    Details
    ISSN: 1432-0517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  Part 1 covered the early development of EURACHEM and its formal establishment in July 1989. Part 2 covers the subsequent activities, describes the global developments that followed from initiatives taken by EURACHEM and also gives a description of the EURACHEM work programme including the workshops and seminars that have been organised and the EURACHEM guides that have been published.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690050435
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity (2003)
    Oxford, UK : Blackwell Science, Ltd
    International journal of cosmetic science 25 (2003), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dandruff is a common problem in approximately 30% of the world's population. Reports in the literature regarding treatment of this condition with various antidandruff shampoos usually report the level of active ingredient within the formulation. However, we propose that a more important parameter relating to antidandruff efficacy is the amount of active ingredient delivered to the scalp from the shampoo. This report describes the results from two studies designed to investigate the relationship between the level of zinc pyrithione (ZnPTO) deposited onto the scalp and the resultant scalp condition. A double-blind randomized vehicle-controlled clinical study comparing three shampoos – a vehicle, a low-depositing ZnPTO shampoo and a high-depositing ZnPTO shampoo – was carried out in the U.K. with 53 panelists with dandruff or mild-to-moderate seborrheic dermatitis of the scalp. Both shampoos containing ZnPTO were significantly superior in antidandruff efficacy to the vehicle. Furthermore, the high-depositing ZnPTO shampoo was significantly superior compared with the low-depositing ZnPTO shampoo in terms of both antidandruff efficacy and antimycotic activity. Antidandruff performance and antimycotic activity of ZnPTO-containing shampoos is highly dependent on the amount of active ingredient delivered to the scalp. Furthermore, careful manipulation of the formulation parameters of an antidandruff shampoo can result in enhanced levels of delivery of the active ingredient without having to increase the level of active ingredient within the formulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1467-2494.2003.00183.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Elderly lifestyles in the 21st century: Doris and Sid's excellent adventure (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of communication 50 (2000), S. 0 
    Details
    ISSN: 1460-2466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2466.2000.tb02849.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Physiology The ACE gene and muscle performance (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 403 (2000), S. 614-614 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Angiotensin-converting enzyme in human skeletal muscle can be encoded by either of two variants of the ACE gene, one of which carries an insertion of 287 base pairs. This longer allele gives rise to lower enzyme activity, and is associated with enhanced endurance performance and an anabolic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35001141
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Field and modelling studies to assess the risk to UK groundwater from earth-based stores for livestock manure (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 17 (2001), S. 0 
    Details
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Boreholes have been constructed at eight sites on the Permo-Triassic Sandstone and Chalk aquifers to assess the extent of chemical and microbiological contamination emanating from unlined farm manure stores. Slurry along fracture faces in the Chalk was found on cores taken from beneath two stores. Porewaters from the Chalk sites and one of the Sandstone sites were discoloured and showed high concentrations of nitrate, ammonium and organic carbon to depths in excess of 10 m. Although Cryptosporidia and Escherichia coli O157 were found in many of the cattle slurry lagoons, neither were found in the aquifer material beneath. The self-sealing of unlined slurry stores is seen as a crucial step in minimizing leakage. A simple mass balance shows farm boreholes near to contaminant sources are at greater risk than public supply wells. Contaminant modelling shows discontinuing use of an unlined farm manure store will lead to little difference in solute concentrations over the short to medium term. Groundwater is most at risk where the water table is shallow since direct hydraulic connection between the lagoon base and the water table considerably increases the rate of vertical migration. This is of greatest significance for pathogens that are thought to be relatively short lived in the subsurface. Under the majority of situations minimal threat is posed to potable groundwater drinking supplies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1475-2743.2001.tb00018.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Investigating preferential flow in a large intact soil block under pasture (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 16 (2000), S. 0 
    Details
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. A large soil block was constructed to determine the importance of preferential flow routes compared with matric flow pathways at a pasture site in mid-Devon. The sandy loam soil was well structured and uniform. The soil block measured 5 m×3 m×1 m and was instrumented with an array of 54 tensiometers, TDR wave guides and suction samplers connected to an in situ chloride analysis system. Four steady state irrigation experiments were conducted with a range of rainfall intensities. During each experiment chloride and nitrate tracers were applied and the patterns of movement were observed. Although the application of tracer was uniform and the soil was relatively homogeneous, there was large variability across the block in terms of time taken to reach the peak concentration (TPC) and the peak concentration itself. About 44 samplers operated at the greatest intensities (10–2 mm h−1) and only 35 at the smallest (1 mm h−1). No relationship was found between TPC and depth. The fastest TPC and largest concentrations were associated with the greatest rainfall intensities. Relative importance of the individual water pathways was a function of soil heterogeneity: parts of the soil block were highly active with several pathways having short TPCs and conductivities in excess of 4 m day−1 whereas other areas had longer TPCs and conductivities of 1–2 m day−1. The pattern was also dynamic, with conductivities of the pathways changing through time, though most of the faster pathways maintained their greater conductivities for more than one year.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1475-2743.2000.tb00207.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...