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  • 2005-2009  (2)
  • 1995-1999  (3)
  • 1
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Sedimentation rate and changes in relative sea level affect early diagenetic cementation along key stratal surfaces within the deeply buried Upper Jurassic Fulmar Formation, South Central Graben, UKCS. As a result of the bioturbated nature of the shallow marine strata, variations in ichnofabrics and cross-cutting relationships between trace fossils are important in identifying and correlating stratal surfaces. Two transgressive and two regressive surfaces/sequence boundaries were studied, using petrographical, mineralogical and geochemical techniques. Cements, including early diagenetic pyrite framboids, grain-rimming apatite, microcrystalline dolomite and ankerite, occur at, above and immediately below both transgressive and forced regressive surfaces/sequence boundaries. Breaks or subdued rates of sedimentation associated with both types of surfaces meant that the sediment package resided within early diagenetic zones for prolonged periods of time, enhancing diagenetic reactions at and below the surfaces. The distribution of ankerite, despite being a deep-burial cement, was primarily controlled by concentrations of bioclasts that are particularly abundant at transgressive surfaces. The diagenetic character of the forced regressive surfaces/sequence boundaries is more complex than that of the transgressive surfaces, both in terms of mineralogy and paragenesis. This is attributed to the superimposition of diagenetic assemblages as a result of erosion, re-sedimentation and sediment by-passing. Although the diagenetic signature of the surfaces has been modified by dissolution/replacement reactions during deep burial, early diagenetic signatures can still be distinguished.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Detailed three-dimensional (3-D) observations of sandy point-bar deposits from the River South Esk in Scotland were made using very closely spaced (metres) vibracores and ground-penetrating radar (GPR) profiles. In order to explain the origin of the observed patterns of deposition, use was made of previous studies of channel geometry, flow and sediment transport. In addition, the mode and nature of channel migration and point-bar accretion were determined using published maps, aerial photographs and detailed topographic surveys. Point-bar deposits accumulated in response to channel-bend expansion and downstream migration, resulting in preservation of sequences that fine upwards and downstream. Lower-bar deposits are mainly very-coarse to coarse sands with medium-scale trough cross-strata overlying basal gravels: associated radar facies are generally low-amplitude, relatively discontinuous inclined reflectors. Upper-bar deposits are mainly fine to medium sands with medium- and small-scale cross-strata and vegetation-rich layers: associated radar facies are generally moderate- to high-amplitude, laterally continuous, inclined reflectors. Large-scale inclined stratasets seen in GPR profiles resulted from episodic point-bar accretion. Abrupt lateral changes in inclination of these stratasets, and preservation of distinct unit bars (bar heads, scroll bars), lower-bar platforms and inner-bank swale fills, record discrete episodes of erosion and deposition associated with floods with recurrence intervals of decades to centuries. Such detailed 3-D description and interpretation of these large-scale features of point-bar deposits was only possible through the use of GPR profiles tied closely to cores, and through the availability of much previously collected information on channel geometry, water flow, sediment transport, erosion and deposition.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Magnetotelluric and seismic data, collected during the MELT experiment at the southern East Pacific Rise, constrain the distribution of melt beneath this mid-ocean-ridge spreading centre and also the evolution of the oceanic lithosphere during its early cooling history. Here we focus on ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 195 (1999), S. 183-190 
    ISSN: 1573-4919
    Keywords: AVP ; cardiomyocyte ; cytosolic free calcium ([Ca2+]i) ; protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Arginine vasopressin (AVP) has been shown to promote vascular smooth muscle cell hypertrophy and hyperplasia of fibroblasts. The present study examines the effect of AVP and endothelin-1 (ET-1) on protein, DNA, and RNA synthesis in primary cultures of serum deprived neonatal rat cardiomyocytes (RC) as assessed by changes in [3H] phenylalanine, [3H] thymidine, and [14C] uridine incorporation respectively. Both AVP and ET-1 evoked significant increases in protein synthesis in RC of 36 ± 12% (p 〈 0.05) and 53 ± 22% (p 〈 0.01) respectively. The stimulating action of AVP on [3H] phenylalanine incorporation was abolished by pretreatment with 2-nitro-4carboxyphenyl-N, N-diphenylcarbamate (NCDC), a phospholipase C (PLC) inhibitor. [14C] uridine incorporation was significantly higher in cells incubated with ET-1 (95 ± 12%) but not AVP (9 ± 11%). Neither AVP nor ET-1 significantly affected cell number or [3H] thymidine incorporation, suggesting a lack of a hyperplastic effect. AVP evoked an increase in [Ca2+]i levels (162 ± 12 nmol/L from a basal value of 77 ± 6 nmol/L) which was completely abolished by pretreatment with either NCDC or cyclopiazonic acid (sarcoplasmic reticulum (SR) Ca2+ pump inhibitor) but unaffected by ryanodine (ryanodine sensitive SR Ca2+ store depletor). Taken together, these data suggest that AVP, in a PLC dependent manner, stimulates both protein synthesis and augments [Ca2+]i release in RC from ryanodine insensitive (IP3 sensitive) Ca2+ stores. Thus, AVP may promote cardiac hypertrophy via direct effects on cardiomyocyte protein synthesis secondary to IP3 mediated [Ca2+]i release.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1530-0358
    Keywords: Anus ; Ultrasonography ; Manometry ; Fecal incontinence ; Surgery ; Hemorrhoids ; Fistula ; Fissure-in-ano
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Anorectal surgery can lead to fecal soiling and incontinence. Whether surgery changes the anatomy and causes symptoms is unknown. Anatomic changes can be visualized by anal endosonography. METHODS: We studied 50 patients after hemorrhoidectomy (24), fistulectomy (18), and internal sphincterotomy (8). Symptoms were assessed, and anal endosonography, anal manometry, mucosal electrosensitivity, and neurophysiologic tests were performed. RESULTS: In 23 (46 percent) patients, a defect of the anal sphincter was found (13 patients had an internal sphincter defect, 1 had an external sphincter defect, and 9 had a combined sphincter defect), 3 after hemorrhoidectomy, 13 after fistulectomy, and 7 after internal sphincterotomy. Seven patients had symptoms, and they all had a sphincter defect. In the other 16 of 23 patients (70 percent), the sphincter defect did not produce symptoms. An internal sphincter defect lowered maximum basal pressure and shortened sphincter length. CONCLUSION: Anal endosonography can reveal sphincter defects after anorectal surgery. Seventy percent of the patients in this group had no complaints; therefore, defects were unsuspected. This has clinical implications in the evaluation of patients with fecal incontinence.
    Type of Medium: Electronic Resource
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