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  • 2000-2004  (8)
  • 1995-1999  (13)
  • 1910-1914  (1)
  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mutations in the basement membrane collagen gene COL4A5 cause the progressive renal glomerular nephropathy and typical hearing loss that occur in X-linked Alport syndrome. Nearly all cases involve distinct mutations, as expected for an X-linked disease that significantly reduces the fitness of affected males. A few exceptional COL4A5 mutations appear to be associated with a reduced disease severity and may account for a significant proportion of late-onset Alport syndrome in populations where a founder effect has occurred. The novel mutation reported here, COL4A5 arg1677gln, has been detected in three independently ascertained Ashkenazi-American families, causes a relatively mild form of nephritis with typical onset in the fourth or fifth decade, and may be involved in the etiology of a large proportion of adult-onset hereditary nephritis in Ashkenazi Jews.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To examine how maternal diet in pregnancy and parental body size and birthweight influence an infant's thinness at birth measured by a low ponderal index.Design An observational study of newborn infants and their parents.Setting Southampton, England.Population Five hundred and thirty-eight infants born at term.Main outcome measure Ponderal index at birth.Results Women who had a high intake of carbohydrate in early pregnancy and a low intake of dairy protein in late pregnancy tended to have infants that were thin at birth (P= 0.01 and P= 0.03, respectively, in a simultaneous analysis). Women who themselves had a low birthweight also tended to have thin infants, ponderal index falling from 28.3 kg/m3 to 26.2 kg/m3 as the women's birthweights decreased from more than 4.0 kg to 2.5 kg or less (P 〈 0.0001). Tall fathers had thin infants, but ponderal index was not related to the women's heights or the fathers’ birthweights.Conclusion These associations may reflect constraints on placental development imposed by a woman's nutrition in pregnancy and during her own intrauterine life. Effects of the father's height may be mediated through genetic influences on skeletal growth.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine how diet of the mother in pregnancy influences the blood pressure of the offspring in adult life.Design A follow up study of men and women born during 1948–1954 whose mothers had taken part in a survey of diet in late pregnancy.Setting Aberdeen, Scotland.Population Two hundred and fifty-three men and women born in Aberdeen Maternity Hospital.Main outcome measure Systolic and diastolic blood pressure.Results The relations between the diet of mothers and their offsprings' blood pressure were complex. When the mothers' intake of animal protein was less than 50 g daily, a higher carbohydrate intake was associated with a higher blood pressure in the offspring (a 100 g increase in carbohydrate being associated with a 3 mmHg increase in systolic pressure (P= 0.02)). At daily animal protein intakes above 50 g, lower Carbohydrate intake was associated with higher blood pressure (a 100 g decrease in carbohydrate being associated with an 11 mmHg rise in systolic blood pressure (P= 0.004)). These increases in blood pressure were associated with decreased placental size.Conclusion Mothers' intakes of animal protein and carbohydrate in late pregnancy may influence their offsprings' adult blood pressure. This may be mediated through effects on placental growth.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 107 (2000), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine how diets of women in pregnancy influence the glucose-insulin metabolism of their offspring in adult life.Design A follow up study of men and women born during 1948–1954 whose mothers had taken part in a survey of diet in late pregnancy.Setting Aberdeen, Scotland.Population One hundred and sixty-eight men and women born in the Aberdeen Maternity Hospital.Main outcome measure Plasma glucose and insulin concentrations, fasting and after a standard oral glucose challenge.Results The offspring of women who had high intakes of fat and protein in late pregnancy had a reduced plasma insulin increment between fasting and 30 min with a 7.0% decrease in increment (P= 0.007) per 10 g increase in protein intake and a 4.9% decrease (P= 0.002) per 10 g increase in fat intake. This was independent of the mother's body mass index or weight gain in pregnancy. A low maternal body mass index in early or late pregnancy was associated with a raised fasting plasma insulin concentration with a decrease of 2.4% (P= 0.05) per 1 kg/m2 increase of maternal body mass.Conclusion High intakes of protein and fat during pregnancy may impair development of the fetal pancreatic beta cells and lead to insulin deficiency in the offspring. The offspring of thin mothers tend to be insulin resistant.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6–8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises ...
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Grass and forage science 59 (2004), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Moisture and treading treatments were imposed on intact turves that were relocated to a glasshouse after being removed from three hill pastures of different soil fertility in the North Island of New Zealand. The experiment consisted of a 2-month stress phase, where the treatments were wetting (W), wetting and treading (WT), drying (D) and control (C). In this phase, herbage accumulation rate, tiller density and leaf extension rate were lower on the D turves, and herbage accumulation rate and tiller density were lower on the WT turves than for the C turves. Herbage accumulation rate was higher on the W treatment than on the C treatment.In the 2-month recovery phase, herbage accumulation rate and leaf extension rate on the D turves were higher than those of the C treatment. Herbage accumulation rate and tiller density took longer to recover on the WT turves but by the end of the recovery period tiller density on these turves exceeded that of the C turves and the original tiller densities on the WT turves. Changes (increase or decrease) in leaf extension rate were associated with the W treatment and tiller density with the WT treatment. Moisture was limiting on the D and C turves, but on the W and WT turves, where moisture was adequate for plant growth, nutrients were limiting, notably phosphorus on the W and WT turves and sulphur on the W turves.The D treatment turves recovered very quickly once the stress was removed but the WT turves were slower to recover. Under the experimental conditions applied, the hill pasture turves were more resilient to the drying treatment than the wetting and treading treatment.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Grass and forage science 59 (2004), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A small-plot field experiment on grazed hill country pastures in the North Island of New Zealand was conducted to examine the productivity and compositional characteristics of swards in response to variation in pasture species diversity. The balanced incomplete factorial design incorporated variation in location, slope, soil fertility and combinations of eight plant functional groups (C4 grasses, annual grasses, annual legumes, perennial C3 grasses, perennial legumes, perennial forbs, ryegrass and browntop). Net herbage accumulation and botanical composition were measured at 18 months (spring) and 24 months (autumn) after oversowing following application of a systemic herbicide. Analysis of variance indicated a significant positive relationship between the number of functional groups sown and herbage accumulation of the sown species in spring, but not with total herbage accumulation. Regression analysis showed that herbage accumulation was also affected by the identity of the functional groups. However, the statistical models indicated that pasture productivity was most strongly influenced by site factors. There was a significant negative relationship between both the number and herbage accumulation of unsown species and the number of functional groups sown, indicating a positive relationship between diversity and resistance to invasion by unsown species. A comparison of the vegetation between the plots before and after oversowing showed that those more diverse prior to sowing returned to their initial composition more rapidly, evidence that diverse vegetation was more resilient in the face of disturbance.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Grass and forage science 52 (1997), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Appropriate pre-sowing methods for the introduction of improved forage legume and grass germplasm are an important issue for hill pasture improvement in New Zealand. A pastoral fallow, which involves not defoliating pasture for a period generally from late spring/early summer to autumn, could create a potentially favourable environment for introducing improved germplasm. A field study was conducted on two aspects (shady and sunny) of moist, low-fertility hill country with or without added fertilizer (phosphorus and sulphur) in the southern North Island of New Zealand, to investigate the changes in plant population density and sward structure during a full or partial pastoral fallow, compared with a rotationally grazed pasture. A 7-month (October to May) pastoral fallow dramatically decreased the densities of grass tillers by 72% (P 〈 0·01), white clover (Trifolium repens L.) growing points by 87% (P 〈 0·01) and other species by 87% (P 〈 0·05). The decline in tiller density by pastoral fallow was enhanced on the shady aspect. Fertilizer application increased white clover growing-point density on the shady aspect (P 〈 0·05) and grass tiller density on the sunny aspect (P 〈 0·05). Decreased plant density during pastoral fallowing was attributed to aboveground biomass accumulation, which altered sward structure, leading to interplant competition and mortality by self-thinning and completion of the life cycle of some matured plants. The plant size-density relationship during pastoral fallowing in this mixed-species sward followed the serf-thinning rule, particularly when the calculation was based on all plant species rather than grass alone. There was no significant (P 〉 0·05) difference in final plant population density between the 7-month pastoral fallow and a shorter term (October to December) pastoral fallow. It is concluded that pastoral fallowing effectively reduced the plant population density and altered sward structure of a hill pasture. Such changes create a more favourable environment for the introduction of improved forage species.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Winter flounder, Pseudopleuronectes americanus, caught in Passamaquoddy Bay, New Brunswick, Canada, and held captive under crowded conditions, developed mixed infections of Trichodina murmanica Polyanski, 1955 (Ciliophora) and Gyrodactylus pleuronecti Cone, 1981 (Monogenea). A protocol involving sequential sieving was used to separate the two species of parasites and produce viable experimental baths. Replicate groups of juvenile, hatchery-reared flounder received one of the following treatments: mixed bath of G. pleuronecti and T. murmanica, bath of G. pleuronecti, bath of T. murmanica or parasite-free (controls). The abundance of both parasites correlated negatively with condition factor of the flounder (r=−0.354, P 〈 0.001 for Trichodina; r=–0.205, P 〈 0.05 for Gyrodactylus). During the periods of peak parasite abundance (1–2 weeks postinfection), the effect of the two parasite species was additive, as mean condition factor and the percentage change in weight were significantly lower (ANOVA, P 〈 0.05) among fish with mixed infections compared to single infections or controls. The most common signs of tissue pathology were increased density of epidermal mucous cells on the fins and macrovesicular lipidosis of the hepatocytes. After a significant decline in parasite infrapopulations (3 weeks postinfection), infected fish resumed normal growth, indicating the observed effects were somewhat reversible.
    Type of Medium: Electronic Resource
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