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  • 1
    ISSN: 1365-3121
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: Seismic refraction measurements were made in August 1988 to study the crustal structure off Lofoten, Northern Norway. Twenty-four 3-component Ocean Bottom Seismographs (OBS) were used, of which seven were deployed in the area covered by landward-flowing basalt deposited during the early Eocene break-up between Norway and Greenland. The main purpose of the OBS survey was to investigate whether this method can be used to map structures below the basalt, which is not easy to penetrate with conventional seismic reflection techniques. The records obtained showed that the OBS data contain considerable information about structures below the flood-basalt; preopening sediments up to 4.0 km thick is indicated below the 1.0–2.5 km-thick landward-flowing basalt. The success of the OBS survey indicates that such measurements can become an important tool in investigations on passive volcanic margins and, potentially, in other areas where highly reflective boundaries make the reflection technique difficult to apply.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 40 (1994), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We attempted to establish a null cell line from NZBxNZW(B/W)Fl mice in order to investigate a regulatory role of null cells during polyclonal B cell activation in autoimmune diseases. NB2.2, a representative subclone of resulting null cell lines, was maintained in long-term tissue culture with 10% mouse ConA supernatant (MCAS). Interestingly, the cell free supernatant of the NB2.2 cells (NB-CFS) showed marked synergistic effects on IgM secretion by B cells induced by IL-5. In addition, NB-CFS had the ability to augment the production of autoantibodies against bromelain-treated mouse red blood cells (BrMRBC) and single-stranded DNA (ssDNA) by B cells induced by IL-5. To determine whether NB2.2 cells induce polyclonal B cell activation and autoantibody generation in vivo, BALB/c mice were injected with NB2.2 cells. The results showed that the level of anti-ssDNA antibodies in sera of BALB/c mice injected with NB2.2 cells was significantly higher than that of control BALB/c mice injected with FDC-P2 cells. In addition, splenic B cells from mice injected with NB2.2 cells significantly proliferated in vitro in response to IL-4 and IL-5, and produced anti-ssDNA antibodies in the presence of IL-5. These results suggest that NB2.2, a null cell line established from B/WF1 mice, produces mediators capable of promoting polyclonal B cell activation and inducing autoantibody secretion, and that this kind of null cell may play an important role in the pathogenesis of autoimmune diseases.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1365-246X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: In 1988, an extensive geophysical experiment was performed on the Lofoten passive continental margin, which was formed by the continental break-up between Greenland and northern Norway at 58 Ma. The geological units of the outer Lofoten margin are characterized by seaward-dipping reflectors (SDRs) and landward flood basalt, which extends up to 100 km landwards of SDRs. In this study, we obtain the P-wave velocity structure beneath the Lofoten Basin, the SDRs, and the landward flood basalt by use of ocean-bottom seismograph refraction profiling, and we also discuss the formation of the northern Norwegian passive continental margin.In the Lofoten Basin the crust is of oceanic type, consisting of sedimentary layers, oceanic laver 2 (4.9−5.5 km s−1), layer 3A (6.3−6.8 km s−1) and layer 3B (7.0−7.1 km s−1). Beneath the SDRs the crustal layers are identical to those of the Lofoten Basin, but the thickness of the lower crust, which represents the same velocity as layer 3B, increases to 5 km towards the continent side, and a high-velocity lower crustal layer (7.3 km s−1) is formed at the base of the crust. The ocean-continent transition zone is situated between the landward side of the SDRs and the northward continuation of the Vøring Plateau Escarpment. In this region the velocity of the lower crust gradually decreases and approaches the lower crustal velocity beneath the Lofoten Islands (6.8 km s−1). The model also indicates that the high-velocity layer disappears in this region. Comparing our model with the crustal structure on the Vøring margin, it is clear that the lower crustal body (≥7 km s−1) thickens southwards along the northern Norwegian continental margin. Recent results from petrological and geophysical studies of the generation of the oceanic crust have shown that increasing the temperature of the upwelling asthenospheric material increases the thickness of the oceanic crust. We interpret this as that the oceanic crust in the southern area in the Vøring-Lofoten margin was generated by hotter material than that of the northern area.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 102 (1990), S. 0 
    ISSN: 1365-246X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: In 1984 an extensive geophysical investigation was conducted in the northernmost part of the Ryukyu Island Arc, south of Kyushu Island. Japan. The aim of this investigation was to obtain new information on the nature of crust and upper mantle at the continental margin through various geophysical measurements (seismic profiling, gravity, magnetism, sea beam and heat flow).This paper presents the crust and upper mantle structure deduced from ocean bottom seismographic profiling conducted along two lines. One line, 190 km long, was taken behind the northernmost part of the Ryukyu Island Arc, parallel to the major tectonic units, i.e. the Okinawa Trough, Ryukyu Arc and Ryukyu Trench. The other, 295 km long, was perpendicular to the tectonic units. Along these profiles, we deployed ocean bottom seismograms spaced 10-20 km apart. As a controlled source, we used both explosives and an airgun array. The experiment was successful and provided quite important information on the tectonics of a trench-island arc-back arc system.The velocity structure obtained for the profile behind the Ryukyu Islands has continental properties. The sediment thickness is 3-4 km. although it shows lateral variations due to basement undulation. The velocities of the upper and lower crust are 5.8-6.2 and 6.6-6.8 km s-1, respectively. The total crustal thickness decreases southwestward, from 27-30 to 23-24 km. This is direct evidence for crustal thinning associated with the process of back-arc spreading.The velocity structure along the profile from the trench to the island arc clearly shows the subduction, accretion and deformation at this margin. The crust beneath the trench has oceanic properties. The sediment thickness is 1.3-3.0 km, beneath which the igneous basement shows severe undulation. The total crustal thickness is 7-8 km. The Pn velocity is slightly less than 8.0 km s-1. Our seismic data revealed a huge sedimentary wedge located 50-150 km landward of the trench. The maximum thickness of this wedge exceeds 12 km. The origin of this wedge may be oceanic because the P-wave velocity in its eastern half is almost comparable to that obtained for the trench area. The velocity structure landward of the wedge is continental and similar to that obtained for the profile behind the island arc.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 114 (1993), S. 0 
    ISSN: 1365-246X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie
    Notizen: A high-quality multichannel seismic reflection line was acquired in 1987 along a 175 km long profile across the continental shelf off Lofoten, northern Norway. A seismic wide-angle experiment was performed in 1988 along the same profile, using seven three-component Ocean Bottom Seismographs (OBS) with 20-25 km spacing and shotpoint intervals of 240 m.The study of the data has shown that the combination of the multichannel reflection and the wide-angle (OBS) technique provides information about the crustal structure beneath the Lofoten shelf that could not have been achieved using only one of the techniques. the multichannel reflection data provide a detailed image of the shallow (Cretaceous) structures, which represents an important basis for inversion of the OBS data. the lower crust and the Moho are also well mapped in some parts of the area with the multichannel reflection technique.The OBS data reveal that significant amounts of pre-Cretaceous sediments exist along almost the entire profile, with a maximum thickness of about 5 km in the Vestfjorden Basin. From the OBS data the thickness of the lower crust is inferred to decrease from about 11.5 km under the Røst High to about 2 km below the Lofoten Ridge. the OBS data indicate further that the Moho position under the Vestfjorden Basin is considerably deeper than can be inferred from the reflection data.About 10km below Moho a strong dipping event is observed in the OBS data. This upper mantle reflection might be related to a possible seaward dipping master fault, and/or presence of layers of partially hydrated peridotite.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We report a 4-year-old female mongrel dog with a history since birth of erosions and atrophic skin, with pigmentation and alopecia on the face, trunk and extremities, together with dystrophic nails. Light microscopy revealed subepidermal blisters with minimal inflammation and electron microscopy confirmed that the ultrastructural site of separation site was at the lamina lucida. Indirect immunofluorescence of the dog's skin detected the positive expression of laminin 5. BPAG2, integrinα6 and type VII collagen. These clinical, ultrastructural and immunohistochemical features suggested that the dog had a non-lethal subtype of junctional epidermolysis bullosa (JEB). This is the first confirmed case of non-lethal JEB in a dog and presents a possible candidate for an animal model of gene therapy. Further study should provide important information of the phenotype, pathophysiology and prognosis of non-lethal JEB in humans.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 428 (1996), S. 275-280 
    ISSN: 1432-2307
    Schlagwort(e): Varicella-zoster virus ; Herpes zoster ; Immunohistochemistry ; Hair follicle ; Sebaceous gland
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Herpes zoster is caused by reactivation of varicella-zoster virus (VZV) persisting in dorsal root or trigeminal ganglia. To clarify the pathway of viral spread from the ganglia to skin, 16 biopsy specimens of early skin lesions of herpes zoster obtained from the face and trunk of 13 patients were studied histologically and immunohistochemically using monoclonal antibodies to the structural proteins of VZV. VZV-infected cells were detected in the hair follicles in 10 of the 16 specimens and in the epidermis in 2 specimens. Infected cells were localized in the isthmus of every involved follicle (12/12), frequently in the stem (8/10) and infundibulum (6/10), and never in the bulb. The high frequency of follicular involvement in herpes zoster suggests that VZV spreads to the area of skin innervated by myelinated nerves, which end around the isthmus of hair follicles and sebaceous glands.
    Materialart: Digitale Medien
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  • 8
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary. Although human cytomegalovirus (HCMV) predominantly infects epithelial cells in vivo, the majority of studies of HCMV gene expression and replication have been conducted using non-epithelial cell lines in part because of the absence of a good experimental system using epithelial cells. To address the nature of epithelial cell infection, we investigated the susceptibility of an epithelial cell line (K-1034) established from the retinal pigment epithelium to HCMV infection. This cell line exhibited high susceptibility to HCMV, as evidenced by detection of one of the immediate early antigens, IE2, in the nuclei of more than 80% of K-1034 cells at 24 h following inoculation at a multiplicity of infection of 3 plaque forming units per cell. However, the yield after one-step growth of HCMV in K-1034 cells was about twenty-fold less than that in human embryonic lung fibroblast cells. Cytopathic effect (CPE) on K-1034 cells was not prominent in medium supplemented with 10% fetal bovine serum and viral late antigens were detected in less than 5% of K-1034 cells. Interestingly, infected cells expressing late antigens and exhibiting CPE were markedly increased in serum-free medium, even though the yield of infectious HCMV and viral genome copy numbers were almost the same in the different serum concentrations, due to viral instability in the absence of serum. Thus, the progression of late antigens expression and the induction of CPE in infected epithelial cells is influenced by physiological conditions, and are negatively regulated by some serum factor.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 196-201 (Nov. 1995), p. 1731-1736 
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 264-268 (Feb. 1998), p. 1085-1088 
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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