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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1985), S. 181-185 
    ISSN: 1432-1041
    Keywords: althesin ; steroid binding globulins ; drug interaction ; steroid anaesthetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (106M−1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 36 (1986), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Treatment of Clostridium acetobutylicum with allyl alcohol allowed the selection of mutants which were unable to produce n-butanol, whereas the synthesis of acetone and ethanol was unaffected. Enzymatic investigations revealed that all mutant strains were devoid of butyraldehyde dehydrogenase or showed a very low activity of this enzyme as compared to the wild type.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-1285
    Keywords: Key words Palmaz-Schatz-Stent – AVE-Micro-Stent – restenosis-rate – high pressure implantation – morphology of stenosis ; Schlüsselwörter Palmaz-Schatz-Stent – AVE-Micro-Stent – Restenoserate – Hochdruckimplantation – Stenosemorphologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Late results of interventional procedures utilizing coronary stents are largely determined by the rate of restenosis. So far few data are available addressing the effect of stent design, implantation pressure and morphologic factors on this crucial variable. Therefore we analyzed the coronary angiogramms obtained in 259 patients before, immediately after and at 3 to 6 months following stent implantation for obstructive coronary disease. A total of 196 AVE-Micro-Stents and 142 Palmaz-Schatz-Stents were implanted into 307 stenoses. In 126 stenoses there were implanted only Palmaz-Schatz-Stents, in 170 only AVE-Micro-Stents and in 11 Stenoses there were implanted Palmaz-Schatz- as well as Micro-Stents. Restenosis was defined as an over 50% stenosis at follow up. No significant difference was detected with regard to global restenosis rate at an average of 4 months following implantation (Palmaz-Schatz 33%, Micro-Stent 27%). If results were analzyed according to implantation pressure however, there was a significantly lower restenosis rate for AVE Micro-Stens implanted with 〉 10 atm (17%) as compared to ≤ 10 atm (35%, p 〈 0.02) and as compared to Palmaz-Schatz-Stents (34%, p 〈 0.02), which were also implanted with high pressure over 10 atm. In addition to implantation pressure, vessel segment and morphology of stenosis proved to be important determinants of late results. In this series of patients the AVE-Micro-Stent compared favourably to the Palmaz-Schatz-Stent not only with respect to a significantly lower restenosis rate, when implanted with pressures 〉 10 atm, but also with regard to its superior flexibility and handling characteristics.
    Notes: Zusammenfassung Der Langzeiterfolg einer Stent-Implantation wird im wesentlichen durch die Restenoserate bestimmt. Bisher sind noch nicht alle Faktoren geklärt, welche die Restenoserate beeinflussen. Daher wurde in der vorliegenden Studie der Einfluß zweier unterschiedlicher Stentdesigns, der Implantationsart (Hochdruckimplantation 〉 10 atm, Niederdruckimplantation ≥ 10 atm), der Lokalisation der Stenose sowie der Stenose-Morphologie untersucht. Hierzu wurden die koronarangiographischen Untersuchungen von 259 Patienten, bei denen in 307 Stenosen insgesamt 196 Micro- und 142 Palmaz-Schatz-Stents implantiert worden waren, quantitativ vor, direkt nach und 3-6 Monate nach Stent-Implantation retrospektiv ausgewertet. Es fand sich zwischen den beiden Stent-Typen kein signifikanter Unterschied in der Restenoserate (Palmaz-Schatz 33%, Micro 27%). Bei Hochdruckimplantation des Micro-Stents mit Drucken von 〉 10 atm zeigte sich jedoch eine signifikant niedrigere Restenoserate sowohl im Vergleich zu den mit niedrigen Drucken implantierten Micro-Stents (17% versus 35%, p 〈 0,02) als auch im Vergleich zu den nahezu ausnahmslos mit Hochdruck implantierten Palmaz-Schatz-Stents (17% versus 34%, p 〈 0,02). Lediglich 11 Palmaz-Schatz-Stents wurden mit einem Druck von ≥ 10 atm implantiert. Ein Grund hierfür war aus den Untersuchungsprotokollen retrospektiv nicht zu entnehmen. In der LAD lag die Restenoserate mit 39% signifikant höher als in der RCX (21%) und RCA (22%, p 〈 0,02). Bei komplexen Typ-C-Stenosen zeigt sich eine höhere Restenoserate (39%) als bei Typ-A- (17%) und Typ-B-Stenosen (26%, p 〈 0,05). Insgesamt zeigt diese Studie Vorteile für den mit Hochdruck implantierten AVE-Micro-Stent aufgrund seiner geringeren Restenoserate im Vergleich zum Palmaz-Schatz-Stent.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Kollagenose ; Lupus erythematodes profundus ; Periorbitales Ödem ; Key words Collagenosis ; Lupus panniculitis ; Periorbital edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Periorbital edema may occur initially or in the course of a wide variety of diseases. One of these diseases is lupus panniculitis, a variant of lupus erythematosus, characterized by firm subcutaneous nodules that may ulcerate with subsequent scar formation. We present a case of lupus panniculitis in which the periorbital edema was the initial manifestation. Knowledge about the differential diagnostic possibilities of periorbital edema as well as the different variants of cutaneous lupus erythematosus is important to reach the correct diagnosis.
    Notes: Zusammenfassung Das periorbitale Ödem ist ein Symptom, das initial oder im Verlauf von Erkrankungen verschiedenster Genese auftreten kann. Eine mögliche Assoziation stellt der Lupus erythematodes profundus dar. Diese Krankheit ist durch subkutane knotige und plattenartige Infiltrate gekennzeichnet, welche zu Ulzerationen und narbigen Einziehungen führen können. Anhand eines Fallberichts wird aufgezeigt, daß ein periorbitales Ödem als Initialsymptom den typischen Hautveränderungen eines Lupus erythematodes profundus vorausgehen kann. Die Kenntnis der möglichen Differentialdiagnosen bei periorbitalem Ödem sowie der unterschiedlichen Varianten eines Lupus erythematodes ist für die Diagnosestellung von entscheidender Bedeutung.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Orbitarekonstruktion ; Resorbierbare Implantate ; Polylaktat ; Key words Orbital reconstruction ; Biodegradable implants ; Polylactide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a complex animal model in sheep, polydioxanone (PDS®) and polylactic membranes were used for the reconstruction of large orbital-wall defects. In a long-term experiment over 1 year, polylactic implants alone showed the best performance as compared with combinations involving autogenous bone grafts and titanium miniplate fixation. As soon as these polylactic implants are approved for human surgery, they will be used to solve the still challenging problem of anatomical reconstruction of large comminuted fractures of more than one orbital wall.
    Notes: Zusammenfassung In einem experimentellen Modell wurden biodegradierbare Membranen aus Polydioxanon (PDS ® ) resp. Polylaktat zur Rekonstruktion großer Orbitawanddefekte bei Schafen verwendet. Im Langzeitversuch über ein Jahr zeigten diejenigen Rekonstruktionen die besten Resultate, bei welchen ausschließlich biodegradierbare Implantate aus Polylaktat zur Anwendung kamen. Bei gleichzeitiger Verwendung von autologen Knochentransplantaten und Titan-Miniplatten-Osteosynthesen war die anatomische Form der rekonstruierten Orbita weniger zuverlässig gewährleistet. Es darf erwartet werden, dass die klinische Zulassung der Polylaktat-Implantate die chirurgische Wiederherstellung ausgedehnter Trümmerfrakturen mehrerer Orbitawände wesentlich erleichtern wird und zu vorhersehbaren, anatomischen Rekonstruktionen führt.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 69 (1999), S. 373-377 
    ISSN: 1432-0649
    Keywords: PACS: 32.80.Qk; 42.50.Ct; 42.65.Dr
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We propose a new method for the generation of single photons. Our scheme will lead to the emission of one photon into a single mode of the radiation field in response to a trigger event. This photon is emitted from an atom strongly coupled to a high-finesse optical cavity, and the trigger is a classical light pulse. The device combines cavity-QED with an adiabatic transfer technique. We simulate this process numerically and show that it is possible to control the temporal behaviour of the photon emission probability by the shape and the detuning of the trigger pulse. An extension of the scheme with a reloading mechanism will allow one to emit a bit-stream of photons at a given rate.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0649
    Keywords: PACS: 03.75.Fi; 05.30.Jp; 32.80.Pj
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: 5 rubidium-87 atoms released from an Ioffe–Pritchard magnetic trap is investigated experimentally. The expansion dynamics depend only on the trap frequencies, which are determined independently. The data are in good agreement with the expected expansion of a condensate, and are clearly distinct from the behaviour of a classical gas in the hydrodynamic regime.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 17 (1987), S. 1319-1320 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 15 (1985), S. 471-472 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-5036
    Keywords: Al effect ; microprobe analysis ; nutrient uptake ; pH effect ; Picea abies ; stable isotope labelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In a model system using intact spruce trees (Picea abies [L.] Karst.) we followed the path of magnesium, calcium and potassium during uptake into the root and during long-range transport into the shoot, by multiple stable isotope labelling. The roots of two- and three-year-old spruce trees originating from soil culture were removed from the soil and, in part or in toto, exposed to labelling solutions containing the stable isotopes 25Mg or 26Mg, 41K and 42Ca or 44Ca. Optical-emission-spectroscopy (ICP-OES) of plant fractions and labelling solutions was combined with the quantitative analysis of stable isotope ratios in sections of shock frozen, cryosubstituted material using the laser-microprobe-mass-analyser (LAMMA). This combination allowed us to distinguish, both in bulk samples and on the cellular level between (i) the fraction of elements originally present in the plant before the start of the labelling, (ii) the material taken up from the labelling solution into the plant and (iii) any material released by the plant into the labelling solution. In single-root labelling experiments, roots of three-year-old spruce trees, grown in nursery soil, were exposed to various pH conditions. The exchange of Mg and Ca with the labelling solution was nearly 100% in the cell walls of the mycorrhized finest roots. This exchange was only slightly affected by a step down to pH 3.5. The absolute Mg and Ca content in the cell walls was moderately reduced by incubation at pH 3.5 and strongly reduced in the presence of Al at this pH. After a pH 3.5 and 2 mM Al treatment we found Al in the xylem cell walls and the cortex cell lumina at elevated concentrations. To analyse the combined effect of high Al and high proton concentrations on the long-range transport, we used a “split-root system”. The root mass of an intact two-year-old spruce tree, grown in mineral soil, was divided into even parts and both halves incubated in solutions with two sets of different stable isotopes of Mg and Ca (side A: no Al, 25Mg and 42Ca; side B: +Al, 26Mg and 44Ca) and 41K on both sides. We observed a large uptake of Mg, Ca and K into the plant and a pronounced release. The net uptake of all three elements was lower from the Al-doted solution. In cross-sections of the apical shoot we found after seven-day labelling period about 60–70% of the Mg and Ca and 30% of the K content in the xylem cell walls originating from both labelling solutions. The clear majority of the Mg and Ca label originated from the Al-doted side.
    Type of Medium: Electronic Resource
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