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  • 1
    Digitale Medien
    Digitale Medien
    An Interactive Substructure Search System (1977)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 17 (1977), S. 157-163 
    Details
    ISSN: 1520-5142
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ci60011a011
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  • 2
    Digitale Medien
    Digitale Medien
    The NIH-EPA Structure and Nomenclature Search System (1978)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 18 (1978), S. 181-186 
    Details
    ISSN: 1520-5142
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ci60016a001
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  • 3
    Digitale Medien
    Digitale Medien
    A search–match system for X-ray powder diffraction data (1979)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 12 (1979), S. 629-634 
    Details
    ISSN: 1600-5767
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Geologie und Paläontologie , Physik
    Notizen: A computer program which can identify the crystalline component phases of a mixture from its X-ray diffraction pattern is described. The program uses the data base of powder diffraction patterns maintained by the Joint Committee on Powder Diffraction Standards. The `reverse searching' technique employed permits the identification of each component and provides an estimate of confidence in the identification. Errors in measured spacings and intensities are tolerated by the program. The interactive search-match system is available for general use via a networked timeshared computer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0021889879013522
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  • 4
    Digitale Medien
    Digitale Medien
    Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1183-1190 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Antecedent hypoglycaemia ; catecholamines ; counterregulation ; hypoglycaemia ; hypoglycaemia unawareness
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18–24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight nondiabetic subjects aged 23–35 years in the week following antecedent hypoglycaemia. Blood glucose levels were held at plateaus of 5 mmol/l and 2.5 mmol/l for 30 min during hyperinsulinaemic (60 mU · m−2 · min−1) morning clamps on days 1, 3 and 8 of two study periods separated by at least 4 weeks. Measurements were made at time 0, 15 and 30 min of each plateau on each day. On the afternoon of Day 1 we also induced either euglycaemia with a blood glucose level of 5 mmol/l (control week) or hypoglycaemia of 2.9 mmol/l (hypo week) for 2 h in random order. The adrenaline response to morning hypoglycaemia (p〈0.01 on all days) was attenuated on Day 3 (p〈0.05) and Day 8 (p〈0.05) compared to Day 1 of hypo week only. Sweating was also attenuated on Day 3 (p〈0.05) and Day 8 (p〈0.02) of hypo week only. Noradrenaline levels and tremor increased during hypoglycaemia on each study day (p〈0.05) but did not differ between days in either week. During hypo week only, the total symptom score response to hypoglycaemia was attenuated on Day 3 (p〈0.03) but not Day 8 (p=0.10). Autonomic symptoms were similarly affected. In summary, the physiological responses to hypoglycaemia are affected differentially by antecedent hypoglycaemia with sweating and adrenaline responses remaining impaired for at least 5 days.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00422367
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  • 5
    Digitale Medien
    Digitale Medien
    Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1183-1190 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Key words Antecedent hypoglycaemia ; catecholamines ; counterregulation ; hypoglycaemia ; hypoglycaemia unawareness.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18–24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23–35 years in the week following antecedent hypoglycaemia. Blood glucose levels were held at plateaus of 5 mmol/l and 2.5 mmol/l for 30 min during hyperinsulinaemic (60 mU · m−2· min−1) morning clamps on days 1, 3 and 8 of two study periods separated by at least 4 weeks. Measurements were made at time 0, 15 and 30 min of each plateau on each day. On the afternoon of Day 1 we also induced either euglycaemia with a blood glucose level of 5 mmol/l (control week) or hypoglycaemia of 2.9 mmol/l (hypo week) for 2 h in random order. The adrenaline response to morning hypoglycaemia (p 〈 0.01 on all days) was attenuated on Day 3 (p 〈 0.05) and Day 8 (p 〈 0.05) compared to Day 1 of hypo week only. Sweating was also attenuated on Day 3 (p 〈 0.05) and Day 8 (p 〈 0.02) of hypo week only. Noradrenaline levels and tremor increased during hypoglycaemia on each study day (p 〈 0.05) but did not differ between days in either week. During hypo week only, the total symptom score response to hypoglycaemia was attenuated on Day 3 (p 〈 0.03) but not Day 8 (p = 0.10). Autonomic symptoms were similarly affected. In summary, the physiological responses to hypoglycaemia are affected differentially by antecedent hypoglycaemia with sweating and adrenaline responses remaining impaired for at least 5 days. [Diabetologia (1995) 38: 1183–1190]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00422367
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  • 6
    Digitale Medien
    Digitale Medien
    Spectra-structure relationships in carbon-13 nuclear magnetic resonance spectroscopy. Results from a large data base (1979)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 12 (1979), S. 289-296 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A link between a substructure searching system and a 13C NMR data base has been established and permits the retrieval and examination of the chemical shifts associated with specific substructures. The means by which these searches are accomplished is described and the results from the searches are presented and discussed. The system is interactive, and can be used to locate in the data base the chemical shifts of carbon atoms in precisely defined environments. Alternatively, it may be used to learn the range of the chemical shifts possessed by particular types of carbon atoms, such as N-methyl or O-methyl carbons.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1270120508
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  • 7
    Digitale Medien
    Digitale Medien
    A carbon-13 nuclear magnetic resonance spectral data base and search system (1978)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 11 (1978), S. 535-540 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A data base containing approximately 4000 13C nuclear magnetic resonance spectra has been assembled. The spectra have been evaluated and all the corresponding compounds have been registered by the Chemical Abstracts Service (CAS). The data base is available to the international scientific community on magnetic tape or microfiche and is also the basis of a search system operating upon an international computer network.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1270111102
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