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  • 1995-1999  (1)
  • 1975-1979  (3)
  • 1960-1964  (3)
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Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Evolution of East Pacific Rise hydrothermal vent fluids following a volcanic eruption (1995)
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 47-50 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] In April 1991 evidence of a very recent lava flow was discovered on the axis of the East Pacific Rise (EPR) between 9° 45' and 9° 52' N at 104° 17' W9, confirmed by radiometric dating of the lavas8 to have occurred no more than two weeks before our first dive ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/375047a0
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Species differences in plasma binding and tissue uptake of 3H-digitoxin (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 291 (1975), S. 371-383 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Digitoxin ; Plasma binding ; Tissue uptake ; Species differences
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The content of cardiac glycosides in plasma and several organs of rats and mice was investigated 30 min and 12 hrs after i.p. administration of 160 μg/kg b.w. 3H-digitoxin. In rat plasma a glycoside concentration of 124.8 and 44.7 ng/ml resp. was found. The corresponding values in the liver were 834.7 and 579.7 ng/g w.w. An opposite liver/plasma distribution was obtained in mice: while in plasma 772.5 and 571.8 ng/ml were recovered, the glycoside concentration in liver was relatively small (284.8 and 235.6 ng/g w.w.). In order to find out the reason for such species differences observed in vivo, liver slices of rats and mice were incubated with 3H-digitoxin in a medium with and without various plasma proteins. The uptake of 3H-digitoxin into liver slices was drastically reduced by adding mouse plasma or albumin to the medium, while rat plasma lowered the uptake far less. These differences are well reflected by binding studies on agargel electrophoresis: only in mouse plasma a binding of 3H-digitoxin could be demonstrated. The binding rate and binding constant analyzed by equilibrium dialysis were higher in mouse than in rat plasma. It is concluded that the lower tissue accumulation in mice compared to rats must be due to the affinity of 3H-digitoxin to mouse plasma albumin. Moreover digitoxin has a higher affinity to the rat than to the mouse liver in the presence of mouse or rat plasma as well as of bovine serum albumin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501795
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  • 3
    Digitale Medien
    Digitale Medien
    Drug interactions in intestinal absorption of3H-digitoxin in rats (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 613-614 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The absorption of3H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0×10−2 M), ethacrynic acid (0.5×10−3 M), and mersalyl (8.0×10−3 M) indicating that digitoxin absorption is at least partly an active process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01990193
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  • 4
    Digitale Medien
    Digitale Medien
    Intestinal transport of 3H-digitoxin in vitro incompatible with simple diffusion (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 289 (1975), S. 217-227 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Digitoxin ; Intestinal Transport ; Dose Dependence ; Functional Asymmetry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary On everted jejunal segments of mice the transfer and tissue uptake of 3H-digitoxin, over a concentration range from 2×10−10–1×10−4M, was investigated from the mucosal (“m”) to the serosal (“s”) side as well as in the opposite direction. 1. The time course of the absorption of 3H-digitoxin and some other compounds investigated (glucose, urea, p-aminohippurate) gave evidence of functional integrity throughout the 75 min-periods of the experiments. 2. When 3H-digitoxin was applied to the mucosal side the permeability coeffcient showed a dose-dependent increase but returned to lower values at higher concentrations. When 3H-digitoxin was administered to the serosal side the permeability coefficient showed a dose-dependent decrease at high concentrations. The ratio of both coefficients “m” → “s”/“s” → “m” increased dose-dependently from 0.4–2.6. 3. The uptake of 3H-digitoxin — applied on the serosal side — into the tissue was independent of dose. However, having administered 3H-digitoxin on the mucosal side the tissue accumulation was 2–5 fold higher and the tissue/medium (T/M) ratio increased within the concentration range from 3.0–9.0. 4. Under DNP (1 mM) the asymmetry and dose dependence of the permeability and tissue uptake of 3H-digitoxin observed in controls were almost abolished. Therefore it is likely that the transfer of 3H-digitoxin in the intestine involves a mechanism more complex than simple diffusion. The existence of more than a two compartment system and/or the contribution of an active transport mechanism is suggested.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499976
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  • 5
    Digitale Medien
    Digitale Medien
    Zur Kenntnis des Systemes SiO2/H2O. Silanol- und Wassergehalte in amorphen, hochkondensierten Kieselsäuren und ihr Verhalten bei De- und Rehydratisierung (1960)
    Springer
    Colloid & polymer science 169 (1960), S. 18-28 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01502548
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  • 6
    Digitale Medien
    Digitale Medien
    Reaktivitäten der Siloxanbindung bei acidolytischer Spaltung (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 273-274 
    Details
    ISSN: 0044-8249
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ange.19640760612
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  • 7
    Digitale Medien
    Digitale Medien
    Sensitivity of the Siloxane Linkage towards Acidolytic Cleavage (1964)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 3 (1964), S. 310-310 
    Details
    ISSN: 0570-0833
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/anie.196403101
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