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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 29 (1964), S. 3108-3110 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Keywords: Tumour necrosis factorα ; Interleukin-1β ; Myeloperoxidase ; Tissue-chamber (mouse) ; Inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A tissue-chamber model of inflammation in mice has been modified and used to investigate the kinetics of zymosan-induced inflammatory mediators such as tumour necrosis factorα (TNFα), interleukin-1β (IL-1β) and prostaglandin E2 (PGE2). In addition, the influx of polymorphonuclear leukocytes (PMN) into the chamber fluid and the granuloma surrounding the chamber was measured by myeloperoxidase (MPO) activity using a new microtitre plate assay. TNFα and IL-1β reached peak concentrations at 3 and 6 h respectively after zymosan injection. Intermediate high concentrations of IL-1β were observed until the end of the experiment at 72 h, but TNFα concentrations decreased from 24 h to biologically insignificant values. In contrast, exudate PGE2 and MPO activity increased up to 24 h after zymosan injection and remained high until 72 h. At 6h after zymosan challenge, oral pre-treatment with prednisolone (3 to 30mg/kg) dose-dependently reduced TNFα, IL-1β and PGE2 concentrations while indomethacin (0.3 to 3 mg/kg) significantly attenuated PGE2, slightly enhanced TNFα and had no effect on IL-1β concentrations in the exudate. Both drugs had similar potencies against exudate and tissue MPO activities. Prednisolone inhibited IL-1β at 72 h post-zymosan. Indomethacin was more potent than prednisolone against PGE2 (ID50 of 〈0.3 versus 0.6mg/kg). The data obtained confirm the usefulness and reliability of this model in evaluating the effects of anti-inflammatory agents on inflammatory mediators induced by zymosan.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 158 (1999), S. 1012-1012 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The heme-containing dehaloperoxidase from Amphitrite ornata was crystallized from an unbuffered solution containing 30% PEG 8000 and 200 mM ammonium sulfate by the hanging-drop vapor-diffusion method. Dark-red bipyramidal crystals are orthorhombic in space group P212121 with unit-cell dimensions a = 68.5, b = 68.4 and c = 61.1 Å. The asymmetric unit contains two subunits related by a non-crystallographic twofold axis. The crystals scatter beyond 2 Å resolution. The native data have been collected and one single-site mercury derivative has been found. SIRAS phasing was used to determine the positions of the heme Fe atoms and structure determination is in progress. A preliminary spectroscopic investigation indicates that the heme is protoporphyrin IX and its coordination sphere resembles that of a typical heme peroxidase, i.e. histidine ligated. Detailed spectroscopic and electrochemical studies are now under way.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 1328-1329 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An ion-exchange resin system must provide at least three basic requirements to function as a suitable medium for plants. First, the physical conditions of a desirable growth medium must be provided. Secondly, the cation and anion resins used must be compatible at the desired pTL of the system, that ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 195 (1962), S. 1075-1076 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] OLDOINYO LENGAI is an active volcano lying some ten miles south of Lake Natron in the eastern or Gregory Rift Valley of northern Tangan yika. It is a composite cone consisting mainly of ijolitic and nephelinitic pyroclastics which contain ejected blocks of urtite, ijolite, melteigite, ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 381-382 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 In the present work barium chloride in concentrations varying from 5 x 10-5 to 10~2 barium/ potassium atoms was added to melts of potassium chloride and single crystals grown from the melt by the Kyropoulos method5. The crystals were cleaved to produce specimens of about 0-5 mm. thick and ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 475-475 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Spectrographic analyses of the kimberlites reveal that the trace elements, like the major elements, can be divided into two contrasting suites: (a) those'in amounts typical of ultrabasic rocks; (6) those in amounts typical of alkaline late differentiates. Like the ultrabasic potassic rocks of ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 10 (1963), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Inc
    Journal of metamorphic geology 15 (1997), S. 0 
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Ultrahigh-temperature quartz-sapphirine granulite xenoliths in the post-Karoo Lace kimberlite, South Africa, comprise mainly quartz, sapphirine, garnet and sillimanite, with rarer orthopyroxene, antiperthite, corundum and zinc-bearing spinel; constant accessories are rutile, graphite and sulphides. Comparison with assemblages in the experimentally determined FMAS and KFMASH grids indicates initial equilibration at 〉1040 °C and 9–11 kbar. Corona assemblages involving garnet, sillimanite and minor cordierite developed on a near-isobaric cooling P–T  path as both temperature and, to a lesser extent, pressures decreased. Garnet-orthopyroxene Fe-Mg exchange thermometers record temperatures of only 830–916 °C. These estimates do not indicate the peak metamorphic conditions but instead reflect the importance of post-peak Fe-Mg exchange during cooling. Correction of mineral Fe-Mg compositions for this exhange using a convergence approach of Fitzsimons & Harley (1994) leads to retrieved P–T  estimates from garnet-orthopyroxene thermobarometry (c. 1000 °C and 10.5±0.7 kbar) that are consistent with the petrogenetic grid constraints. U-Pb dating of a single zircon grain gives an age of 2590±83 Ma, interpreted as the age of the metamorphic event. Protolith major and trace element chemistries of the xenoliths differ from sapphirine-quartzites typical of the Napier Complex (Antarctica) but are comparable to less siliceous, high Cr and Ni, sapphirine granulites reported from several ultrahigh temperature granulite terranes.
    Type of Medium: Electronic Resource
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