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  • 1
    Digitale Medien
    Digitale Medien
    Photodynamic Therapy (PDT) of Gastrointestinal Tumours: A New Light Delivery System (1998)
    Springer
    Lasers in medical science 13 (1998), S. 137-142 
    Details
    ISSN: 1435-604X
    Schlagwort(e): Keywords: Colorectum; Intraluminal probe; Non-laser light source; Oesophagus; Paterson lamp; Photodynamic therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Physik , Technik allgemein
    Notizen: Abstract. The Paterson lamp is a convenient, low cost, portable, alternative light source to lasers for photodynamic therapy (PDT). A multiwavelength capability enables the clinician to vary the photosensitiser used. The Paterson lamp has been applied in the field of dermatology using a liquid light guide with distal optics for surface application. We now describe distal optics suitable for use with this light guide for intraluminal applications in the oesophagus and colorectum. The geometry of the site (oesophagus and colorectum) requires distal optics such as a cylindrical diffuser or a side-fire diffuser. We have designed new probes that diffuse light radially from the guide axis (cylindrical diffusion). The tips have a frosted glass surface that scatters and effectively couples light radially into the tissue. An acrylic spacer is placed over the diffuser to position the tissue at a constant diameter from the probe. This is held in position by a silicone sheath placed over the distal one metre. For use in the oesophagus, a channel, to facilitate intubation over a guide wire, is included. The diameter of the entire probe is 8.4 mm and the power output can be adjusted from 0–500 mW. Pilot PDT of tubulovillous adenomas of the rectum and Barrett's oesophagus using this light delivery system is currently underway and has shown good early response in the treated area.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101030050067
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  • 2
    Digitale Medien
    Digitale Medien
    Structure of Kephalin: Presence of Serine and a Disaccharide in Groundnut Kephalin (1950)
    [s.l.] : Nature Publishing Group
    Nature 165 (1950), S. 314-315 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Formula (I) has never, in fact, been entirely free from objection, since published analytical data are far too low in carbon, nitrogen and phosphorus. Moreover, it is not easy to explain on the basis of structures (I) and (II) the extreme insolubility in alcohol of kephalin, compared with lecithin, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/165314b0
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  • 3
    Digitale Medien
    Digitale Medien
    The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers (1995)
    Springer
    Diabetologia 38 (1995), S. 467-473 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin ; resistance arteries ; vascular reactivity ; EDRF
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Impaired reactivity of the resistance vasculature may contribute to the development of diabetic microangiopathy by altering microvascular haemodynamics. This study investigates the acute effects of insulin on the contractility and relaxation properties of isolated human resistance arteries (〈300 Μm internal diameter) taken from gluteal subcutaneous fat of 33 (18 male: 15 female) normotensive healthy volunteers (supine blood pressure 115.6±1.6/ 70.0±1.5 mm Hg [mean±SEM], with no family history of hypertension or diabetes mellitus. Resistance arteries were mounted in a small vessel myograph to measure isometric tension. Contractile responses to noradrenaline were reduced after incubation in 1 mU/ml of insulin for 20 min (p〈0.01; Group 1). Increasing concentrations of insulin were found to reduce the contractile response to noradrenaline in a dose-dependent manner (Group 2; 0.1 mU/ml by 8% [p〈0.01], 1 mU/ml by 17% [p〈0.02] and 10 mU/ml by 22% [p〈 0.01]). Sensitivity to insulin (ED50) only decreased at the highest concentration of insulin. However, acetycholine-induced relaxation was not altered by insulin (Group 2). Time control studies (Group 3) showed that contractile and relaxation responses over the 4-h study period were unchanged. Furthermore, the length of time the vessels were exposed to insulin did not progressively impair responses (Group 4). These findings suggest that insulin may induce abnormalities in vascular smooth muscle contractility, a factor that may contribute to or exacerbate the abnormal haemodynamics observed in the capillary microcirculation of numerous vascular beds in diabetes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00410285
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  • 4
    Digitale Medien
    Digitale Medien
    The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers (1995)
    Springer
    Diabetologia 38 (1995), S. 467-473 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Key words Insulin ; resistance arteries ; vascular reactivity ; EDRF.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Impaired reactivity of the resistance vasculature may contribute to the development of diabetic microangiopathy by altering microvascular haemodynamics. This study investigates the acute effects of insulin on the contractility and relaxation properties of isolated human resistance arteries ( 〈 300 μm internal diameter) taken from gluteal subcutaneous fat of 33 (18 male: 15 female) normotensive healthy volunteers (supine blood pressure 115.6 ± 1.6/70.0 ± 1.5 mm Hg [mean ± SEM], with no family history of hypertension or diabetes mellitus. Resistance arteries were mounted in a small vessel myograph to measure isometric tension. Contractile responses to noradrenaline were reduced after incubation in 1 mU/ml of insulin for 20 min (p 〈 0.01; Group 1). Increasing concentrations of insulin were found to reduce the contractile response to noradrenaline in a dose-dependent manner (Group 2; 0.1 mU/ml by 8 % [p 〈 0.01], 1 mU/ml by 17 % [p 〈 0.02] and 10 mU/ml by 22 % [p 〈 0.01]). Sensitivity to insulin (ED50) only decreased at the highest concentration of insulin. However, acetycholine-induced relaxation was not altered by insulin (Group 2). Time control studies (Group 3) showed that contractile and relaxation responses over the 4-h study period were unchanged. Furthermore, the length of time the vessels were exposed to insulin did not progressively impair responses (Group 4). These findings suggest that insulin may induce abnormalities in vascular smooth muscle contractility, a factor that may contribute to or exacerbate the abnormal haemodynamics observed in the capillary microcirculation of numerous vascular beds in diabetes. [Diabetologia (1995) 38: 467–473]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00410285
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  • 5
    Digitale Medien
    Digitale Medien
    The topoisomerase II-associated protein, Pat1p, is required for maintenance of rDNA locus stability in Saccharomyces cerevisiae (1999)
    Springer
    Molecular genetics and genomics 261 (1999), S. 831-840 
    Details
    ISSN: 1617-4623
    Schlagwort(e): Key words Genetic recombination ; Ribosomal DNA ; Topoisomerase II ; Radiation ; Genome instability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The Pat1 protein of Saccharomyces cerevisiae was identified during a screen for proteins that interact with topoisomerase II. Previously, we have shown that pat1Δ mutants exhibit a slow-growth phenotype and an elevated frequency of both mitotic and meiotic chromosome mis-segregation. Here, we have studied the effects of deleting the PAT1 gene on chromosomal stability, with particular reference to rates of homologous recombination within the rDNA locus. This locus was analyzed because rDNA-specific hyperrecombination is known to occur in conditional top2 mutants. We show that pat1Δ strains mimic top2 mutants in displaying an elevated rate of intrachromosomal excision recombination at the rDNA locus, but not elsewhere in the genome. The elevated rate of recombination is dependent upon Rad52p, but not upon Rad51p or Rad54p. However, pat1Δ strains display additional manifestations of more general genomic instability, in that they show mild sensitivity to UV light and an increased incidence of interchromosomal recombination between heteroalleles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004380050027
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  • 6
    Digitale Medien
    Digitale Medien
    Detection and typing of human papillomavirus DNA in paired urine and cervical scrapes (1999)
    Springer
    European journal of epidemiology 15 (1999), S. 537-543 
    Details
    ISSN: 1573-7284
    Schlagwort(e): Cervical specimens ; DNA sequencing ; Human papillomavirus ; polymerase chain reaction (PCR) ; restriction fragment length polymorphism (RFLP) ; Urine specimens
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The prevalence of human papillomavirus (HPV) in paired cervical scrape and urine specimens from 144 women attending a clinic for genitourinary medicine was determined by polymerase chain reaction (PCR) and nested PCR, using degenerate and general primer pairs localized within the L1 region. HPV typing was by restriction fragment length polymorphism (RFLP), type-specific PCR (HPV 6, 11, 16, 18, 33), and partial DNA sequencing of PCR products. HPV DNA was detected in 114 (84%) women. HPV DNA was detected in the specimens of 58 patients after amplification with MY09/MY11 primers and in a further 54 patients after nested PCR with the GP5 + /GP6 + primers. A total of 106/136 (78%) of women had HPV DNA positive cervical scrapes and 89 (65%) had HPV DNA positive urine specimens. Both the urine and cervical specimens of 81 women were positive. In 25 women HPV DNA was detected in the cervical specimen only, and in 8 women HPV DNA was detected in the urine specimens only. A total of 108 specimens from 75 patients were typed. For 33 patients HPV typing was achieved in both the cervical and the urine specimens and 19 women had identical types in paired specimens. Multiple HPV infections could be detected in 15 (20%) of 75 women where either the cervical and urine specimen or both of the specimens could be typed. More then one HPV type was found in 8 specimens and from multiple sites (cervix and urinary tract) in the same patients on 7 occasions. The results of this study indicate that the detection of HPVs in the urogenital tract can be maximised through the testing of both cervical scrapes and urine specimens in conjunction with the use of a nested PCR to increase the sensitivity of HPV DNA detection. Also, urine cannot be a direct substitute for a cervical scrape as different HPV types are often detected in the urine compared with those detected in the cervix.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007574231879
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