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  • 1
    Digitale Medien
    Digitale Medien
    GC/MS analysis of urinary excretion of 9α,11β-PGF2 in acute and exercise-induced asthma in children (1998)
    Oxford BSL : Blackwell Science Ltd
    Clinical & experimental allergy 28 (1998), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 9α,11β-Prostaglandin (PG) F2 is an initial metabolite of PGD2 which has a potent bronchoconstrictive activity.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectivesWe measured the urinary levels of 9α,11β-PGF2 in asthmatic children to investigate its role in not only acute asthmatic attack in a time course study but also in exercise-induced asthma (EIA).〈section xml:id="abs1-3"〉〈title type="main"〉MethodsIn the acute asthma study, 30 asthmatic children were examined. Urine samples were collected on the first, third, and sixth days. Urinary levels of 9α,11β-PGF2 were measured with gas chromatography mass spectrometry using the electron impact method. In the exercise challenge study, 14 children with EIA and 14 children without EIA were studied. Urine samples were collected before exercise challenge, and at 1 h, and 5 h after exercise challenge. Urinary levels of 9α,11β-PGF2 were measured.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsElevated urinary levels of 9α,11β-PGF2, which were observed on the first day when treatment was started in the hospital, were gradually decreased on the third day (P 〈 0.05), and on the sixth day (P 〈 0.01). A significant correlation between urinary levels of 9α,11β-PGF2 and symptom scores (P 〈 0.005) was observed on the first day. In EIA, there was a significant increase in urinary levels of 9α,11β-PGF2 at 1 h (P 〈 0.01) and at 5 h (P 〈 0.01) after exercise challenge, but not in the children without EIA.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion9α,11β-PGF2 may be involved in the pathogenesis of acute and exercise-induced asthma in children.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.1998.00187.x
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  • 2
    Digitale Medien
    Digitale Medien
    Radiological assessment of the position of the tibial tuberosity by means of a marking wire in knees with patellofemoral arthritis (1999)
    Springer
    Skeletal radiology 28 (1999), S. 27-32 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Patellofemoral arthritis ; Tibial tuberosity ; Axial radiograph
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Objective. To assess the usefulness of a new axial radiographic technique in knees with patellofemoral arthritis (PF-OA). Design and patients. After a marking wire had been attached to the skin on the tibial tuberosity so that the wire matched the width of the patellar tendon, an axial radiograph was taken at 30° of flexion in 16 normal knees and 14 PF-OA knees in which computed tomographic analysis had revealed a laterally positioned tibial tuberosity at 30° of flexion. The distance of the marking wire from the lateral condyle and from the patellar groove was compared between the two groups. Results. The marking wire was located significantly laterally in PF-OA knees compared with normal knees. Conclusion. An axial radiograph with a marking wire on the tibial tuberosity is useful for assessing the position of the tibial tuberosity in PF-OA knees.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050468
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  • 3
    Digitale Medien
    Digitale Medien
    Apoptosis in the development of the temporomandibular joint (1997)
    Springer
    Anatomy and embryology 196 (1997), S. 383-391 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Key words Temporomandibular joint ; Development ; Apoptosis ; Transmission electron microscopy ; DNA fragmentation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Apoptosis has been shown to be involved in remodeling of organs during development, and derangement of the apoptotic process may result in temporomandibular joint (TMJ) dysfunction or congenital malformation. To investigate the relationship between the development of the TMJ and apoptosis, rat fetuses at 17.5–20.5 days of gestation (E17.5–20.5, vaginal plug=E0) and rats at postnatal days 1, 2, 3, 5, and 10 (P1, 2, 3, 5, and 10) were examined by light (LM) and transmission electron microscopy (TEM) and electrophoretic analysis of DNA fragmentation. At E17.5 and 18.5, a few layers of slender mesenchymal cells which eventually develop into the TMJ disk were observed, although TEM or electrophoresis did not reveal apoptotic cells at these stages. At E19.5 and 20.5, all structures of the TMJ except the lower joint cavity could be distinguished, but at these stages apoptotic cells were not observed. In P1 condyles, apoptotic cells were observed by TEM both at the subsurface of the condyle and in the region at which the lateral pterygoid muscle attaches to the condyle. These apoptotic cells showed irregular chromatin condensation, convolution of the cell membrane, and fragmentation and disintegration of the cytoplasm. Electrophoretic analysis of the P1 condyle further confirmed DNA fragmentation. Apoptosis was not observed in all specimens at the P1 stage. It was confirmed in 8 out of 20 animals (10 out of 27 joints) by TEM and/or electrophoretic analysis. The shape of the upper portion of the condyle flattened progressively from E20.5 to P2. At this stage, the lower joint cavity was developing, as observed by LM. These findings suggest that the morphological changes of the mandibular condyle effected by apoptosis, together with development of the lower joint cavity, play important roles in the postnatal functional adaptation to external stimuli such as mechanical strain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004290050106
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  • 4
    Digitale Medien
    Digitale Medien
    Perikaryal projections of developing spinal ganglion neurons in the chick demonstrated by scanning electron microscopy (1997)
    Springer
    Anatomy and embryology 195 (1997), S. 137-146 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Key words Perikaryal projection ; Metabolic exchange of neurons ; Scanning electron microscopy ; Morphometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The perikaryal projections of sensory ganglion neurons in chick embryos were observed by scanning electron microscopy after removal of the connective tissues and satellite cells by enzymatic digestion treatment. The perikaryal projections were seen not only on the surface of the perikarya but also on the surface of the stem processes. The projections were up to 3 μm in length, and their transverse diameters ranged between 0.12 and 0.24 μm from incubation (embryonic) day 10 to posthatching day 2. On days 6 and 8 of incubation, thicker projections with transverse diameters of 0.24–0.9 μm were observed transiently in addition to those described above, and some of them looked like vestiges of neuronal processes during development. The thin projections emerging mainly in the later developmental stages increased in number as spindle-shaped bipolar neurons differentiated into (pseudo)unipolar cells. Morphometric analysis revealed that the density of perikaryal projections correlated well with the shape and size of each neuron; thin perikaryal projections were more numerous on those of mature pseudounipolar neurons than on the surface of premature ganglion neurons, and they increased in number as the individual ganglion cell bodies grew larger. The neuronal shape- and size-dependent increase in perikaryal projections during development may support the hypothesis that perikaryal projections are structural devices for increasing neuronal surface areas and possibly the efficiency of metabolic activities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004290050032
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  • 5
    Digitale Medien
    Digitale Medien
    Über die schädliche Wirkung von Hepato- und Lienotoxin auf das Auge (1938)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 139 (1938), S. 503-512 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Zusammenfassung Meine Kaninchenversuche ergaben, daß das Hepato- und Lienotoxin bei geeigneter Anwendung auf das Auge eine schädliche Wirkung ausüben können. Der pathologische Prozeß spielt sich dabei im wesentlichen an der retinalen Pigmentschicht ab, in schwereren Fällen ist auch die eigentliche Netzhaut mitergriffen. Die hier aufgetretenen Veränderungen decken sich ophthalmoskopisch wie auch histopathologisch mit den durch das Nephrotoxin bedingten so gut wie vollkommen. Durch diese Tatsachen ist die Annahme für die spezifische Beziehung zwischen der Netzhaut und Niere als unrichtig erwiesen und somit auch die daraus gezogene Folgerung, daß nephrotoxische Stoffe beim Menschen zum Zustandekommen der Retinitis albuminurica eine wesentliche Rolle spielen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02084735
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  • 6
    Digitale Medien
    Digitale Medien
    Klinische und experimentelle Untersuchungen über die durch Raupenhaare hervorgerufenen Veränderungen des Augenhintergrundes (1939)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 140 (1939), S. 70-85 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01853474
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  • 7
    Digitale Medien
    Digitale Medien
    Reliability of the anteroposterior axis and the posterior condylar axis for determining rotational alignment of the femoral component in total knee arthroplasty (1998)
    Springer
    Journal of orthopaedic science 3 (1998), S. 194-198 
    Details
    ISSN: 1436-2023
    Schlagwort(e): Key words: total knee arthroplasty ; anteroposterior axis ; epicondylar axis ; posterior condylar axis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: We examined the reliability of the anteroposterior and posterior condylar axes for determining rotational alignment of the femoral component in total knee arthroplasty (TKA). A computed tomography scan was taken at the level of the femoral epicondyle in 84 knees (27 varus knees with medial femorotibial arthritis (FT-OA) in 26 patients, 17 knees with patellofemoral arthritis in 14 patients, and 40 normal knees in 40 volunteers). On the image, an anteroposterior axis, a line perpendicular to the anteroposterior axis, an epicondylar axis and a posterior condylar axis were drawn, and the relationship between the three axes was assessed. The mean values for the 84 knees were evaluated, and the posterior condylar axis was 6.0°± 2.4° internally rotated relative to the epicondylar axis, while the line perpendicular to the anteroposterior axis was 1.4°± 3.3° internally rotated relative to the epicondylar axis. The internal rotation angle of the posterior condylar axis relative to the epicondylar axis was 6.2°± 1.9° in the knees with medial femorotibial arthritis, 6.4°± 2.4° in the knees with patellofemoral arthritis, and 5.8°± 2.7° in the normal knees, showing consistent values in normal and osteoarthritic knees. The internal rotation angle of the line perpendicular to the anteroposterior axis relative to the epicondylar axis was 0.1°± 3.3°, 1.3°± 3.3°, and 2.3°± 3.1° in the three groups, respectively (i.e., there were significant differences between the medial FT-OA knees and the normal knees). The results demonstrated that the anteroposterior axis was rotated externally to a significant degree in medial FT-OA knees and was less reliable than the posterior condylar axis for use in alignment for TKA on medial FT-OA knees.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007760050041
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  • 8
    Digitale Medien
    Digitale Medien
    Aneurysm of the major vessels in neurofibromatosis (1998)
    Springer
    Archives of orthopaedic and trauma surgery 117 (1998), S. 110-113 
    Details
    ISSN: 1434-3916
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The case of a patient who presented with a ruptured aneurysm of the brachial artery and type I neurofibromatosis is presented. Angiography revealed a ruptured aneurysm of the brachial artery in the middle of the upper arm. Repair of the artery with autogenous vein grafting was impossible due to the extremely brittle brachial artery and accompanying veins. The blood supply distal to the aneurysm was secured by collaterals, and the aneurysm, including a relatively long portion of the brachial artery and veins adjacent to the aneurysm, was resected. The patient died of massive hemorrhage from the subclavian artery of the involved side 9 days postoperatively. Histological and immunohistological examinations of the tissues involved in the ruptured aneurysm were conducted. The resected brachial artery and veins were surrounded by hypertrophied tissue which tested positive for S-100 protein and negative for desmin and action. These findings suggest that the origin of the proliferating tissue was not mesodermal dysplasia, but neurofibroma occurring near or in the vessels. A ruptured aneurysm in a patient with neurofibromatosis should not be treated with reconstruction of the vessels. The treatment of choice is surgical or endovascular occlusion of the vessels involved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00703457
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  • 9
    Digitale Medien
    Digitale Medien
    Aneurysm of the major vessels in neurofibromatosis (1997)
    Springer
    Archives of orthopaedic and trauma surgery 117 (1997), S. 110-113 
    Details
    ISSN: 1434-3916
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The case of a patient who presented with a ruptured aneurysm of the brachial artery and type I neurofibromatosis is presented. Angiography revealed a ruptured aneurysm of the brachial artery in the middle of the upper arm. Repair of the artery with autogenous vein grafting was impossible due to the extremely brittle brachial artery and accompanying veins. The blood supply distal to the aneurysm was secured by collaterals, and the aneurysm, including a relatively long portion of the brachial artery and veins adjacent to the aneurysm, was resected. The patient died of massive hemorrhage from the subclavian artery of the involved side 9 days postoperatively. Histological and immunohistological examinations of the tissues involved in the ruptured aneurysm were conducted. The resected brachial artery and veins were surrounded by hypertrophied tissue which tested positive for S-100 protein and negative for desmin and action. These findings suggest that the origin of the proliferating tissue was not mesodermal dysplasia, but neurofibroma occurring near or in the vessels. A ruptured aneurysm in a patient with neurofibromatosis should not be treated with reconstruction of the vessels. The treatment of choice is surgical or endovascular occlusion of the vessels involved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00703457
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  • 10
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of vancomycin in patients with multiple organ failure during continuous hemodiafiltration (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 296-299 
    Details
    ISSN: 1437-7799
    Schlagwort(e): Key words Vancomycin ; Multiple organ failure ; Continuous hemodiafiltration ; Pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background. Some pharmacokinetic data for vancomycin (VCM) during continuous arteriovenous hemofiltration have been reported, but reports on the effect of continuous venovenous hemodiafiltration (CVVHDF), which is more commonly performed in patients with multiple organ failure (MOF), on VCM pharmacokinetics are scanty. Method. We selected five patients with MOF with serious infection with methicillin-resistant Staphylococcus aureus who needed treatment with VCM during CVVHDF. Blood flow rate was 80 ml/min, and dialysis fluid flow rate and filtration flow rate were both 0.5 l/h. A hemofilter made of polysulfon was used. After administration of 0.5–1.0 g of VCM, serial samples of blood and dialysate/filtrate outflow were obtained during CVVHDF. Pharmacokinetic parameters were calculated by a standard model-independent method. Results. Mean ± SE values for the pharmacokinetic parameters of VCM were: elimination rate constant, 0.0369 ± 0.0124/h; systemic clearance, 25.6 ± 5.0 ml/min; CVVHDF clearance, 15.9 ± 3.4 ml/min; non-CVVHDF clearance, 9.6 ± 8.4 ml/min; and distribution volume, 51.1 ± 21.6 l. The harmonic mean of half-life was 18.9 h. Conclusion. The systemic clearance of VCM during CVVHDF was relatively higher than anticipated. The pharmacokinetic parameters obtained in the present study will be useful to optimize the dose schedule of VCM in patients with MOF being treated with CVVHDF.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101570050050
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