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Digitale Medien

Immunohistochemical study of utrophin and dystrophin at the motor end-plate in myasthenia gravis (1996)

Ito, Hijiri ; Yoshimura, Toshiro ; Satoh, Akira ; [weitere]

Springer

Acta neuropathologica 92 (1996), S. 14-18

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Details

ISSN: 1432-0533

Schlagwort(e): Key words Myasthenia gravis ; Utrophin ; Dystrophin ; Motor end-plate ; Immunohistochemistry

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We studied the densities of utrophin and dystrophin at the motor end-plates of patients with myasthenia gravis (MG) using immunohistochemical analysis. The densities were compared with those found in patients with amyotrophic lateral sclerosis, Lambert-Eaton myasthenic syndrome and normal controls. Utrophin was reduced at the motor end-plates of MG patients, in association with a reduction of α-bungarotoxin binding sites. In contrast, the density of dystrophin at the motor end-plate of MG patients was not significantly different from that found in the controls. We conclude that, at the motor end-plate, utrophin may be more closely associated than dystrophin with the acetylcholine receptor, and that it plays a different role.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004010050483

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