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  • 1
    Electronic Resource
    Electronic Resource
    GAX collagen in the treatment of urinary incontinence in elderly women: a two year follow up (1997)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the efficacy of GAX collagen in the treatment of elderly women with genuine stress incontinence.Design A single centre prospective study.Setting A London teaching hospital.Participants Thirty-four women older than 60 years of age with genuine stress incontinence diagnosed on videocystourethrography.Interventions Up to three paraurethral injections of GAX collagen.Main outcome measures Subjective and pad test assessments performed pre-operatively, after one month, one year and two years after the first injection of collagen. Videocystourethrography and urethral pressure profilometry were carried out pre-operatively, after three months and one year.Results There was a reduction in urinary leakage as measured on pad testing. After two years 77% of the surviving 26 women were symptomatically cured. Objectively after two years 48% of the women were cured and 9% were improved over their initial pre-treatment level of incontinence. The cure rate was the same whether or not the women had undergone previous vaginal surgery. The maximum urethral closure pressure was not increased with treatment indicating that collagen injections do not act by producing obstruction, but this should be interpreted with caution due to the small sample size.Conclusion GAX collagen is an effective method of treating urinary incontinence in the elderly and especially women who have undergone previous continence procedures. The technique is easy to perform and particularly suitable in those who are frail, but if failure occurs after two years consideration needs to be given to its cost effectiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1997.tb10657.x
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of combining scald resistance genes on disease levels, yield and quality traits in barley (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 361-366 
    Details
    ISSN: 1432-2242
    Keywords: Pyramiding ; Hordeum vulgare ssp ; spontaneum ; Rhynchosporium secalis ; Backcross lines ; Isozyme marker genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Pairwise combinations of genes for resistance to scald in barley were developed using linked isozyme markers to test whether such combinations conferred improved resistance to the pathogen, Rhynchosporium secalis. The resistance genes originally derived from Hordeum vulgare ssp. spontaneum. The combinations were bred into an essentially similar genetic background because the scald-susceptible, Australian barley cultivar ‘Clipper’ was the recurrent backcross parent in their ancestry. In field tests of the recombinants over 2 years, disease levels were lower in three of six doubly resistant lines than in backcross lines carrying a single resistance gene, which in turn were less diseased than either ‘Clipper’ or recombinants that lacked the marked resistance genes. All resistant lines significantly outyielded ‘Clipper’ but did not themselves differ significantly. Lines resistant to scald had significantly higher grain size and grain weight. Gains for malt yield of about 1 % were detected in the higher disease environment. Resistance was not accompanied by any obvious “cost” in terms of yield or quality. Protection against scald is therefore a significant requirement for new malting barley cultivars in scald-prone areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223177
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of combining scald resistance genes on disease levels, yield and quality traits in barley (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 361-366 
    Details
    ISSN: 1432-2242
    Keywords: Key words Pyramiding  ;  Hordeum vulgare ssp. spontaneum  ;  Rhynchosporium secalis  ;  Backcross lines  ;   Isozyme marker genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Pairwise combinations of genes for resistance to scald in barley were developed using linked isozyme markers to test whether such combinations conferred improved resistance to the pathogen, Rhynchosporium secalis. The resistance genes originally derived from Hordeum vulgare ssp. spontaneum. The combinations were bred into an essentially similar genetic background because the scald-susceptible, Australian barley cultivar ‘Clipper’ was the recurrent backcross parent in their ancestry. In field tests of the recombinants over 2 years, disease levels were lower in three of six doubly resistant lines than in backcross lines carrying a single resistance gene, which in turn were less diseased than either ‘Clipper’ or recombinants that lacked the marked resistance genes. All resistant lines significantly outyielded ‘Clipper’ but did not themselves differ significantly. Lines resistant to scald had significantly higher grain size and grain weight. Gains for malt yield of about 1% were detected in the higher disease environment. Resistance was not accompanied by any obvious “cost” in terms of yield or quality. Protection against scald is therefore a significant requirement for new malting barley cultivars in scald-prone areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050289
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Characterisation of a gene encoding wheat endosperm starch branching enzyme-I (1999)
    Springer
    Theoretical and applied genetics 98 (1999), S. 156-163 
    Details
    ISSN: 1432-2242
    Keywords: Key words Triticum tauschii ; Starch branching enzyme genes ; Wheat ; Endosperm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A genomic DNA fragment from Triticum tauschii, the donor of the wheat D genome, contains a starch branching enzyme-I (SBE-I) gene spread over 6.5 kb. This gene (designated wSBE I-D4) encodes an amino acid sequence identical to that determined for the N-terminus of SBE-I from the hexaploid wheat (T. aestivum) endosperm. Cognate cDNA sequences for wSBE I-D4 were isolated from hexaploid wheat by hybridisation screening from an endosperm library and also by PCR. A contiguous sequence (D4 cDNA) was assembled from the sequence of five overlapping partial cDNAs which spanned wSBE I-D4. D4 cDNA encodes a mature polypeptide of 87 kDa that shows 90% identity to SBE-I amino acid sequences from rice and maize and contains all the residues considered essential for activity. D4 mRNA has been detected only in the endosperm and is at a maximum concentration mid-way through grain development. The wSBE I-D4 gene consists of 14 exons, similar to the structure for the equivalent gene in rice; the rice gene has a strikingly longer intron 2. The 3′ end of wSBE I-D4 was used to show that the gene is located on group 7 chromosomes. The sequence upstream of wSBE I-D4 was analysed with respect to conserved motifs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051052
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    Paper (German National Licenses)
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