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  • 1995-1999  (4)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Activated Transcription of the Human Neuropeptide Y Gene in Differentiating SH-SY5Y Neuroblastoma Cells Is Dependent on Transcription Factors AP-1, AP-2α, and NGFI (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 70 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF). As determined by transient expression, two NGF response elements (REs) were required for transcription induced by NGF in SH-SY5Y cells with stable expression of an exogenous NGF receptor TRK-A gene (SH-SY5Y/trk). TPA treatment in the presence of serum induced NPY transcription in both wild-type SH-SY5Y (SH-SY5Y/wt) and SH-SY5Y/trk cells. A TPA RE (TRE), overlapping the proximal NGF RE, was identified by expression of the v-Jun oncoprotein that enhanced NPY transcription. Suppression of TPA-induced NPY transcription was obtained by expression of a dominant negative Jun protein, selective protein kinase C inhibition, or introduction of a mutated TRE, whereas NGF-induced NPY transcription was inhibited to a lesser degree. The transcription factor AP-2α was shown to bind cooperatively to the NPY promoter with either AP-1 or NGFI-A to the shared TRE and NGF RE and to the distal NGF RE, respectively. These results show that transcription factors AP-1, AP-2α, and NGFI-A are involved in activated NPY transcription during the onset of neuronal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.70051887.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Roles of Osteopontin in Bone Remodeling (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 760 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb44632.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evolutionary relationship between human major histocompatibility complexHLA-DR haplotypes (1996)
    Springer
    Immunogenetics 43 (1996), S. 304-314 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract HLA-DR haplotypes of the human major histocompatibility complex are organized in five different groups. They can be identified based on the serological specificity expressed by the polymorphicDRB1 locus and by the presence of a characteristic set ofDRB genes. The nucleotide sequences of introns 4 and 5 of the twoDRB genes (DRB1 *01 andDRB6 *01) from aDR1 haplotype and the threeDRB genes (DRB1 *15, DRB6*15, andDRB5 *15), from aDR51 haplotype were determined. This study identified endogenous retrovial long terminal repeat elements (ERV9 LTR) located at identical positions in intron 5 of theDRB1 genes in both theDR1 andDR51 haplotypes. Phylogenetic analyses revealed a close evolutionary relationship between these two haplotypes. TheDRB5 gene, unique for theDR51 haplotype, may have been lost by a recent gene deletion event creating theDR1 haplotype. A model for the evolution of the humanDR haplotypes involving separate duplication and contraction events is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02440998
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  • 4
    Electronic Resource
    Electronic Resource
    Primate DRB genes from the DR3 and DR8 haplotypes contain ERV9 LTR elements at identical positions (1995)
    Springer
    Immunogenetics 41 (1995), S. 74-82 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The HLA-DRB genes of the human major histocompatibility complex constitute a multigene family with a varying number of DRB genes in different haplotypes. To gain further knowledge concerning the evolutionary relationship, the complete nucleotide sequence was determined for a region spanning introns 4 and 5 of the three DRB genes (DRB1*0301, DRB2 and DRB3*0101) from a DR52 haplotype and the single DRB gene (DRB1*08021) in the DR8 haplotype. These analyses identified an endogenous retroviral long terminal repeat element (ERV9 LTR3), inserted at identical positions in intron 5 of the functional DRB genes in these two haplotypes. Comparison of the nucleotide sequence from introns 4 and 5 including the ERV9 LTR elements revealed a strong similarity between the three expressed DRB genes. The DRB3*0101 and DRB1*08021 genes were most similar in this comparison. These findings provide further evidence for a separate duplication in a primordial DR52 haplotype followed by a gene contraction event in the DR8 haplotype. A homologous element was found in a chimpanzee DRB gene from a DR52 haplotype. This represents the first characterized ERV9 LTR element in a nonhuman species. The corresponding introns of the DRB genes in the DR4 haplotype contain no ERV9 LTRs. In contrast, these genes have insertions of distinct Alu repeats, implying distinct evolutionary histories of DR52 and DR53 haplotypes, respectively. Phylogenetic analyses of DRB introns from DR52, DR53, and DR8 haplotypes showed a close relationship between the DRB2 and DRB4 genes. Thus, the ancestral DR haplotype that evolved to generate the DR52 and DR53 haplotypes most likely shared a primordial common DRB gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182316
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    Paper (German National Licenses)
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