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  • 1
    Electronic Resource
    Electronic Resource
    Laser transillumination of breast tissue phantoms using time-resolved techniques (1996)
    Springer
    European radiology 6 (1996), S. 387-392 
    Details
    ISSN: 1432-1084
    Keywords: Time resolve ; Transillumination measurements ; Breast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to evaluate a pulsed laser transillumination technique based on time-resolved detection on breast-tissue-like phantoms. Experiments have been performed on tissue-like plastic phantoms with different scattering characteristics. The effects of time-gate width, size, localisation and refractive index of hidden objects have been scrutinised. Our study showed that the shorter the time-gate the higher the contrast. The contrast is very dependent on the size of the hole, whereas the full width half maximum is not. Furthermore, the investigation showed that the changes of early detected light in an experimental setting is due to scattering, and not to a higher speed of the transmitted light
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180619
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Superficial blood flow following photodynamic therapy of malignant non–melanoma skin tumours measured by laser Doppler perfusion imaging (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue. In this study, the superficial blood perfusion of malignant nonmelanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical ò–aminolaevulinic acid (ALA)–induced protoporphyrin IX as a photosensitizer. The results clearly show that, in contradiction to PDT with the intravenously administered photosensitizer photofrin. no direct vascular damage can be seen. With the topical sensitization the blood perfusion is increased immediately after the treatment irradiation. The increased blood flow is seen up to a week after treatment, in a similiar way as for an inflammatory reaction. Despite this, all basal cell carcinoma and squamous cell carcinoma in situ lesions in this study healed without any sign of residual tumour after the treatment, suggesting an efficient direct tumour cell destruction induced by PDT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1166.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in Local Hepatic Blood Perfusion During Interstitial Laser-Induced Thermotherapy of Normal Rat Liver Measured by Interstitial Laser Doppler Flowmetry (1999)
    Springer
    Lasers in medical science 14 (1999), S. 143-149 
    Details
    ISSN: 1435-604X
    Keywords: Keywords: Interstitial laser therapy; Liver; Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generation source. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44°C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total time of 60 min. At 41°C, a significant increase in perfusion up to 1.3 times the initial value was observed 2–16 min after start of treatment. At 44°C, perfusion decreased continuously during and after treatment, and was significantly different from control 40 min after start of treatment. The results may be valuable in assessing the thermal response of tissues surrounding the target in interstitial laser-induced thermotherapy of liver tumours during conditions of normal blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101030050036
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    Paper (German National Licenses)
    Fulltext
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