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  • 1
    ISSN: 1423-0127
    Keywords: Polyneuropathy ; Gammopathy ; Myelin-associated glycoprotein ; Sulfoglucuronosyl glycolipids ; Sulfoglucuronosyl paragloboside ; Sulfoglucuronosyl lactosaminyl paragloboside ; Autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract About half of the Caucasian patients with chronic polyneuropathy and IgM paraproteinemia show serum anti-myelin-associated glycoprotein (MAG) and anti-sulfoglucuronosyl glycosphingolipid (SGGLs) activities. These antibody activities have been demonstrated to react with a carbohydrate epitope known as the HNK-1 or sulfoglucuronic acid (SGA) epitope. However, in Asian populations the occurrence of serum anti-SGA activities has been reported to be relatively rare. We investigated 5 cases of chronic polyneuropathy with IgM paraproteinemia from Taiwan and found that 3 of them had high-titer serum anti-SGA (SGGL/MAG) antibody activities. The clinical symptoms of these 3 patients were consistent with sensory dominant polyneuropathy with a severer involvement of the lower limbs than of the upper limbs. Electromyography and nerve conduction studies revealed severe sensory nerve involvement (no response in 3 cases) and moderate slowing of motor conduction velocity (MCV) without conduction block. The decrease in MCV correlated well with anti-SGA antibody titer (less than 30 m/s with the titration of 1:12,800, normal 55–60 m/s). Pathological findings showed active demyelinating polyneuropathy with myelin ovoid and myelinated fiber loss. Our data suggest that anti-SGGL antibody activities may not be very rare among Asian populations. Additionally, there seems an intriguing possibility that the titer of this antibody correlates with the severity of peripheral nerve involvement in patients of demyelinating polyneuropathy with IgM paraproteinemia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-601X
    Keywords: PACS: 23.60.+e nbsp;decay – 25.70.Gh Compound nucleus – 27.80.+w 190 ≤ A ≤ 219
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The α-decay energy and halflife of 195mAt were determined to be 6960±20 keV and 385+69 −51 ms respectively, on the basis of genetic correlations in the 169Tm(36Ar, α6n)195At reaction, while those of 195gAt measured simultaneously were 7105±30 keV and 146+21 −17 ms respectively, reconfirming the previously reported values. A new isotope 199Fr was also produced and identified in the same way in the 169Tm(36Ar, 6n)199Fr reaction, yielding Eα= 7655±40 keV and T1/2= 12+10 −4 ms.
    Type of Medium: Electronic Resource
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