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Disproportionate fetal growth and fingerprint patterns (1998)

Wheeler, T. ; Godfrey, K. ; Atkinson, C. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

BJOG 105 (1998), S. 0

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ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Fingerprint whorl patterns are formed during fetal life. In a group of 180 term infants, those with more fingerprint whorls tended to have a small abdominal circumference (P= 0.09) and high ratio of head to abdominal circumference (P= 0.008). These associations were independent of the relation between the whorl counts of the mothers and their infants. We also found an independent correlation between the babies’ whorl count and the combination of increasing subscapular (P= 0.03) and decreasing triceps (P= 0.02) skinfold thicknesses of the mothers. Whorl patterns are associated with adult hypertension; maternal nutritional status may influence their common origin during fetal development.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10159.x

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Automated and graphical methods for locating heavy-atom sites for isomorphous replacement and multiwavelength anomalous diffraction phase determination (1998)

Badger, J. ; Athay, R.

Copenhagen : International Union of Crystallography (IUCr)

Applied crystallography online 31 (1998), S. 270-274

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ISSN: 1600-5767

Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001

Topics: Geosciences , Physics

Notes: We have developed new software for locating heavy-atom sites for phase determination from single isomorphous replacement (SIR) and multiwavelength anomalous diffraction (MAD) data. The first component of the software is a program for finding heavy-atom sites when presented with SIR (i.e. native and derivative) structure-factor amplitudes or MAD-FA structure-factor amplitudes (i.e. the derived structure factors corresponding to the anomalously scattering atoms). The principle on which this program is based is a reciprocal-space maximization of a Patterson correlation coefficient between the SIR or MAD-FA data and the calculated intensities from search atoms placed at trial positions. The program has been successfully tested on two sets of SIR data for the cytochrome c′ protein and on MAD-FA data from the DnaK protein. The second component of the software is a three-dimensional viewer which may be used to assess difference Patterson maps and which provides peak-picking and atom-editing facilities for interpreting cross-difference Fourier maps.