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Oxacillin-hydrolyzing β-lactamase involved in resistance to imipenem in Acinetobacter baumannii (1997)

Hornstein, M ; Sautjeau-Rostoker, C ; Péduzzi, J ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 153 (1997), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Acinetobacter baumannii strain A148, a clinical isolate resistant to imipenem (MIC=32 mg l−1), synthesized two β-lactamases with pIs 6.3 and 〉9.2. The pI 6.3 enzyme hydrolyzed the penicillins, including isoxazoylpenicillins, first-, second- and, to a lesser extent, third-generation cephalosporins. It was inhibited by chloride ions and by the penem β-lactamase inhibitor BRL 42715. Clavulanate was a weak inhibitor and EDTA did not affect the β-lactamase activity. This enzyme also hydrolyzed imipenem with a catalytic efficiency (kcat/Km) of 1500 mM−1 s−1. Moreover, this purified β-lactamase produced a positive microbiological clover-leaf test with imipenem. Therefore, the pI 6.3 β-lactamase was considered to be involved in the imipenem resistance of A. baumannii strain A148.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1574-6968.1997.tb12593.x

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A path integral approach to effective non-linear medium (1998)

Barthélémy, M. ; Orland, H.

Springer

The European physical journal 6 (1998), S. 537-541

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ISSN: 1434-6036

Keywords: PACS. 72.20.Ht High-field and nonlinear effects - 77.84.Lf Composite materials

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Notes: Abstract: In this article, we propose a new method to compute the effective properties of non-linear disordered media. We use the fact that the effective constants can be defined through the minimum of an energy functional. We express this minimum in terms of a path integral allowing us to use many-body techniques. We obtain the perturbation expansion of the effective constants to second order in disorder, for any kind of non-linearity. We apply our method to the case of strong non-linearities (i.e. , where is fluctuating from point to point), and to the case of weak non-linearity (i.e. where and fluctuate from point to point). Our results are in agreement with previous ones, and could be easily extended to other types of non-linear problems in disordered systems.