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The effects of hydrogen peroxide treatment on different life-cycle stages of the salmon louse, Lepeophtheirus salmonis (Krøyer 1837) (1998)

McAndrew, K J ; Sommerville, C ; Wootten, R ; [et al.]

Oxford, UK : Blackwell Science Ltd

Journal of fish diseases 21 (1998), S. 0

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ISSN: 1365-2761

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: The effects of hydrogen peroxide administered at a concentration of 1500 ppm for 20 min at 7.5 °C on different life-cycle stages of Lepeophtheirus salmonis were examined experimentally. The mobile adult and pre-adult stages of L. salmonis readily reattached to Atlantic salmon after hydrogen peroxide treatment. Adult female lice, but not adult males or pre-adults, reattached in significantly lower numbers than untreated controls. Survival of early chalimus stages (I and II) was not affected by hydrogen peroxide treatment, but their subsequent development to chalimus III and IV was delayed compared with untreated controls. Nauplii and copepodid larvae of L. salmonis were almost all dead by 1 hour post-treatment. A very few copepodids survived 24 h post-treatment. Egg strings of L. salmonis at an early stage of development failed to hatch after hydrogen peroxide treatment, but those with pigmented eggs did hatch, although in significantly reduced numbers. Treated egg strings did produce viable copepodids, although in significantly reduced numbers compared with controls.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-2761.1998.00096.x

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Synthesis and pharmacology of a series of new organic nitrate esters (1995)

Bron, J. ; Sterk, G. J. ; Werf, J. F. ; [et al.]

Springer

Pharmacy world & science 17 (1995), S. 120-125

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ISSN: 1573-739X

Keywords: Alcohols ; Chemical synthesis ; Nitrates ; Pharmacology ; Structure-activity relationship ; Vasodilator agents

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract New organic nitrate esters, derived from structurally different (cyclo)aliphatic templates, were synthesized and pharmacologically investigated. Theirin vitro vascular smooth muscle relaxing activities and, occasionally,in vivo haemodynamic profiles were studied and compared to those of the clinically important nitrates, glyceryl trinitrate, isosorbide dinitrate and isosorbide-5-mononitrate. A number of compounds appeared to be even more potent than glyceryl trinitrate. Qualitative structure-activity relationships within the series of new compounds are discussed. In flexiblen-alkylene dinitrates, lipophilicity as well as chain length appears to affectin vitro activity. In semi-rigid cyclohexylene dinitrates, the number of atoms between and the configuration of the nitrate groups may play an important role. Finally, in cycloalkylene mononitrates neither the number of ring carbon atoms nor the lipophilicity clearly affects thein vitro activity. It is suggested that, apart from a limited involvement of compound lipophilicity, other factors such as differences in enzymatic conversion to a common putative bioactive species, nitric oxide, are responsible for the observed differences in activity.