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  • 1
    Electronic Resource
    Electronic Resource
    Epitaxial SrRuO3 thin films on (001) SrTiO3 (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 1047-1049 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Highly conductive metallic oxide thin films of SrRuO3 with single crystalline quality have been grown on (001) SrTiO3 by using pulsed laser deposition. The films have a [00l] orientation with an in-plane relationship of [110]SrRuO3 // [100]SrTiO3. They have excellent metallic behavior with room temperature resistivity of ∼310 μΩ cm and a residual resistance ratio of about 7 at 4.2 K, the largest reported to date. A clear ferromagnetic transition at ∼147 K was detected by resistivity and magnetic measurements. However, the transition becomes blurred as the density-of-point defects increases in the films following a 400 keV proton irradiation with an accumulative dose up to ∼6.0×1016 ions/cm2. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.119723
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  • 2
    Electronic Resource
    Electronic Resource
    Lifetime and degradation effects in polymer light-emitting diodes (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 2441-2447 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The operational lifetime of polymer light-emitting diodes was studied at several temperatures in the range from 25 to 85 °C. When operated in constant current mode, at luminances greater than 100 cd/m 2, lifetimes of around 20 000 h were noted. Two significant changes in performance were found during continuous operation: the luminance of the devices varied in a nonmonotonic fashion, and the operating voltage increased in a linear fashion. Both of these changes were thermally activated, with the changes accelerated at higher temperatures. These changes are also accelerated at higher current densities. We discuss possible mechanisms for these degradation processes. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.369564
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  • 3
    Electronic Resource
    Electronic Resource
    1-Benzoyl-3-(4-nitrophenyl)thiourea (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 1716-1718 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196001047
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  • 4
    Electronic Resource
    Electronic Resource
    1-Benzoyl-3-(4-methoxyphenyl)thiourea (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 1772-1774 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196001989
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  • 5
    Electronic Resource
    Electronic Resource
    In pursuit of the “holy grail”: recombinant allergens and peptides as catalysts for the allergen-specific immunotherapy (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 50 (1995), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This presentation reviews recent progress in knowledge of (i) molecular biology and immunology of allergens and (ii) the methods for the modulation of allergen-specific immune response, with special emphasis on our grass pollen allergens, particularly Pao p IX AL, used as a model. The last few years have seen tremendous progress in molecular characterization of allergens, leading to synthesis of a number of recombinant allergens. Furthermore, studies of the structure-activity relationship of allergens have led to the delineation of the epitopes of these allergens and of widespread cross-reactivities among diverse allergens. In view of the requirement for extensive pre-clinical studies, the application of the recombinant allergens and epitopes in the clinical realm has just begun. Studies in murine systems suggest that these allergens and/or their epitopic peptides downregulate allergen-specific immune responses de novo. The potential and drawbacks of the recombinant allergens and peptides for improving the existing immunotherapeutic approaches and for developing new approaches to specific immunotherapy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1995.tb04275.x
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  • 6
    Electronic Resource
    Electronic Resource
    Millimeter and infrared observations of SGR 1806-20 (1995)
    Springer
    Astrophysics and space science 231 (1995), S. 89-92 
    Details
    ISSN: 1572-946X
    Keywords: Gamma-ray:Bursts ; ISM:Individual (G10.0-0.3) ; Supernova remnants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present CO(1-0) observations toward the soft gamma-ray repeater SGR 1806-20. We discuss the implications on the distance to the X-ray counterpart: AX 1805.7-2025. We also present an upper limit at λ = 1.3 mm for the thermal emission from dust and high resolution IRAS maps of the region. SGR 1806-20 is very likely associated with the H II complex W31. The G10.0-0.3 supernova remnant (SNR) could be expanding in the very low density region produced by the wind of the bright O9-B2 star recently detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00658594
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of MUC1, Thomsen-Friedenreich antigen, Tn, sialosyl-Tn, and α2,6-linked sialic acid in hepatocellular carcinomas and preneoplastic hepatocellular lesions (1999)
    Springer
    Virchows Archiv 434 (1999), S. 503-509 
    Details
    ISSN: 1432-2307
    Keywords: Key words Liver ; Mucin ; Thomsen-Friedenreich-related antigens ; Carbohydrates ; Cytokeratin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The expression of epithelial mucins and Thomsen-Friedenreich-related antigens in preneoplastic and neoplastic hepatocellular lesions was systematically investigated using an in situ immunohistochemical staining approach. MUC1, MUC2, TF, sialosyl-TF, Tn, sialosyl-Tn, α2,3-linked sialic acid, and α2,6-linked sialic acid were examined in normal and cirrhotic human liver and in human hepatocellular carcinomas (HCCs) and cholangiocarcinomas. Normal hepatocytes and preneoplastic foci of altered hepatocytes did not express MUC1, MUC2, TF, Tn, s-Tn, or α2,6-linked sialic acid. In contrast, HCCs showed positive reactions for MUC1, TF, Tn, s-Tn, and α2,6-linked sialic acid. MUC2 was absent in normal biliary epithelial cells, but present in cholangiocarcinomas. The staining of MUC1, or s-Tn and α2,6-linked sialic acid in human normal liver tissues and various liver diseases did not change after specific treatments such as periodate oxidation or saponification, indicating that their expression in HCC does not result from incomplete glycosylation or low O-acetylation, respectively. MUC1, TF, Tn, s-Tn, and α2,6-linked sialic acid may be useful as indicators of progression of HCC in tissue sections, and perhaps also as targets for diagnostic and therapeutic approaches in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050375
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  • 8
    Electronic Resource
    Electronic Resource
    Production of caproic acid by cocultures of ruminal cellulolytic bacteria and Clostridium kluyveri grown on cellulose and ethanol (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 507-513 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Ruminal cellulolytic bacteria (Fibrobacter succinogenes S85 or Ruminococcus flavefaciens FD-1) were combined with the non-ruminal bacterium Clostridium kluyveri and grown together on cellulose and ethanol. Succinate and acetate produced by the cellulolytic organisms were converted to butyrate and caproate only when the culture medium was supplemented with ethanol. Ethanol (244 mM) and butyrate (30 mM at pH 6.8) did not inhibit cellulose digestion or product formation by S85 or FD-1; however caproate (30 mM at pH 6.8) was moderately inhibitory to FD-1. Succinate consumption and caproate production were sensitive to culture pH, with more caproic acid being produced when the culture was controlled at a pH near neutrality. In a representative experiment under conditions of controlled pH (at 6.8) 6.0 g cellulose l-1 and 4.4 g ethanol l-1 were converted to 2.6 g butyrate l-1 and 4.6 g caproate l-1. The results suggest that bacteria that efficiently produce low levels of ethanol and acetate or succinate from cellulose should be useful in cocultures for the production of caproic acid, a potentially useful industrial chemical and bio-fuel precursor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050590
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  • 9
    Electronic Resource
    Electronic Resource
    Production of caproic acid by cocultures of ruminal cellulolytic bacteria and Clostridium kluyveri grown on cellulose and ethanol (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 507-513 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Ruminal cellulolytic bacteria (Fibrobacter succinogenes S85 or Ruminococcus flavefaciens FD-1) were combined with the non-ruminal bacterium Clostridium kluyveri and grown together on cellulose and ethanol. Succinate and acetate produced by the cellulolytic organisms were converted to butyrate and caproate only when the culture medium was supplemented with ethanol. Ethanol (244 mM) and butyrate (30 mM at pH 6.8) did not inhibit cellulose digestion or product formation by S85 or FD-1; however caproate (30 mM at pH 6.8) was moderately inhibitory to FD-1. Succinate consumption and caproate production were sensitive to culture pH, with more caproic acid being produced when the culture was controlled at a pH near neutrality. In a representative experiment under conditions of controlled pH (at 6.8) 6.0 g cellulose 1−1 and 4.4 g ethanol 1−1 were converted to 2.6 g butyrate 1−1 and 4.6 g caproate 1−1. The results suggest that bacteria that efficiently produce low levels of ethanol and acetate or succinate from cellulose should be useful in cocultures for the production of caproic acid, a potentially useful industrial chemical and bio-fuel precursor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169952
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  • 10
    Electronic Resource
    Electronic Resource
    Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative study (1996)
    Springer
    Histochemistry and cell biology 106 (1996), S. 197-207 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  A broad variety of normal human tissues were examined for the expression of Thomsen-Friedenreich (TF)-related histo-blood group antigens, TF (Galβ1-3GalNAcα1-R), Tn (TF precursor, GalNAcα1-R), sialosyl-Tn (NeuAcα2-6GalNAcα1-R), considered to be useful in cancer diagnosis and immunotherapy, and sialosyl-TF, the cryptic form of TF. These antigens or, more correctly, glycotopes, were determined by immunohistochemistry with at least two monoclonal antibodies (mAbs) each (except sialosyl-TF) as well as by lectin histochemistry. For a better dissection of sialosyl-TF and TF glycotopes, tissue sections were pretreated with galactose oxidase or the galactose oxidase-Schiff sequence. Staining with mAbs appeared to be more restricted than with the lectins used. Distribution patterns among normal epithelia were different for all four antigens. These antigens were also detected in some non-epithelial tissues. They can be classified in the following sequence according to the frequency of their occurrence in normal tissues: sialosyl-TF 〉 〉sialosyl-Tn 〉Tn 〉TF. Most of the positively staining sites for TF, Tn, and sialosyl-Tn are located in immunologically privileged areas. The complex results obtained with anti-TF mAbs (after treatment of the tissue sections with sialidase from Vibrio cholerae) and the lectins amaranthin and jacalin revealed a differential distribution of the subtypes of sialosyl-TF [NeuAcα2-3Galβ1-3GalNAcα1-R and Galβ1-3 (NeuAcα2-6)GalNAcα1-R] in normal human tissues. From our data it can be inferred that TF, Tn, and sialosyl-Tn are promising targets for a cancer vaccine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050032
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