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  • 1
    Electronic Resource
    Electronic Resource
    Characterisation of Human 5-Hydroxytryptamine2A and 5-Hydroxytryptamine2C Receptors Expressed in the Human Neuroblastoma Cell Line SH-SY5Y: Comparative Stimulation by Hallucinogenic Drugs (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Stable transfection of the human neuroblastoma cell line SH-SY5Y with the human 5-hydroxytryptamine2A (5-HT2A) or 5-HT2C receptor cDNA produced cell lines demonstrating ligand affinities that correlated closely with those for the corresponding endogenous receptors in human frontal cortex and choroid plexus, respectively. Stimulation of the recombinant receptors by 5-HT induced phosphoinositide hydrolysis with higher potency but lower efficacy at the 5-HT2C receptor (pEC50 = 7.80 ± 0.06) compared with the 5-HT2A receptor (pEC50 = 7.30 ± 0.08). Activation of the 5-HT2A receptor caused a transient fourfold increase in intracellular Ca2+ concentration. Whole-cell recordings of cells clamped at −50 mV demonstrated a small inward current (2 pA) in response to 10 µM 5-HT for both receptors. There were no differences in potency or efficacy of phosphoinositide hydrolysis among four hallucinogenic [d-lysergic acid diethylamide (LSD), 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (DOI), 5-methoxy-N,N-dimethyltryptamine, and mescaline] and three nonhallucinogenic drugs (m-chlorophenylpiperazine, quipazine, and ergotamine). Comparison of equipotent doses producing 20% of the maximal response induced by 5-HT revealed selective activation of the 5-HT2A receptor by LSD and to a lesser degree by DOI, mescaline, and ergotamine. Quipazine and 5-methoxy-N,N-dimethyltryptamine were relatively nonselective, whereas m-chlorophenylpiperazine selectively activated the 5-HT2C receptor. It is unlikely therefore that hallucinosis is mediated primarily by activity at the 5-HT2C receptor, whereas activity at the 5-HT2A receptor may represent an important but not unique mechanism associated with hallucinogenic drug action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67062521.x
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  • 2
    Electronic Resource
    Electronic Resource
    Electron paramagnetic resonance of erbium doped silicon (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 3854-3856 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electron paramagnetic resonance measurements have been made on samples of float zone silicon, implanted with 1015 Er/cm2. One sample was coimplanted with oxygen to give an impurity concentration of 1020 O/cm3 and 1019 Er/cm3. In this coimplanted sample, sharp lines are observed which are identified as arising from a single spin 1/2 Er3+ center having a g tensor exhibiting monoclinic C1h symmetry. The principal g values and tilt angle are g1=0.80, g2=5.45, g3=12.60, and τ=2.6°. In the absence of O, the sharp lines are not observed. No Er3+ cubic centers were detected in either sample. Possible structures for the center are discussed. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.117127
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  • 3
    Electronic Resource
    Electronic Resource
    A thermodynamic formulation of hydrous cordierite (1995)
    Springer
    Contributions to mineralogy and petrology 119 (1995), S. 155-165 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  A thermodynamic formulation of hydrous Mg-cordierite (Mg2Al4Si5O18⋅nH2O) has been obtained by application of calorimetric and X-ray diffraction data for hydrous cordierite to the results of hydrothermal syntheses. The data include measurements of the molar heat capacity and enthalpy of hydration and the molar volume. The synthesis data are consistent with a thermodynamic formulation in which H2O mixes ideally on a single crystallographic site in hydrous cordierite. The standard molar Gibbs free energy of hydration is −9.5±1.0 kJ/mol (an average of 61 syntheses). The standard molar entropy of hydration derived from this value is −108±3 J/mol-K. An equation providing the H2O content of cordierite as a function of temperature and fugacity of H2O is as follows (n moles of H2O per formula unit, n〈1): n=f  V H2 O/(f V H2 O+exp[−3.8389−5025.2(1T−1298.15) −ln(T298.15)−(298.15T−1)] ) Application of this formulation to the breakdown reaction of Mg-cordierite to an assemblage of pyrope-sillimanite-quartz±H2O shows that cordierite is stabilized by 3 to 3.5 kbar under H2O-saturated conditions. The thermodynamic properties of H2O in cordierite are similar to those of liquid water, with a standard molar enthalpy and Gibbs free energy of hydration that are the same (within experimental uncertainty) as the enthalpy and Gibbs free energy of vaporization. By contrast, most zeolites have Gibbs free energies of hydration two to four times more negative than the corresponding value for the vaporization of water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004100050033
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  • 4
    Electronic Resource
    Electronic Resource
    A thermodynamic formulation of hydrous cordierite (1995)
    Springer
    Contributions to mineralogy and petrology 119 (1995), S. 155-165 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A thermodynamic formulation of hydrous Mg-cordierite (Mg2Al4Si5O18·nH2O) has been obtained by application of calorimetric and X-ray diffraction data for hydrous cordierite to the results of hydrothermal syntheses. The data include measurements of the molar heat capacity and enthalpy of hydration and the molar volume. The synthesis data are consistent with a thermodynamic formulation in which H2O mixes ideally on a single crystallographic site in hydrous cordierite. The standard molar Gibbs free energy of hydration is-9.5±1.0 kJ/mol (an average of 61 syntheses). The standard molar entropy of hydration derived from this value is-108±3 J/mol-K. An equation providing the H2O content of cordierite as a function of temperature and fugacity of H2O is as follows (n moles of H2O per formula unit, n〈1): $$\begin{gathered}n = {{f_{{\text{ H}}_{\text{2}} O}^{\text{V}} } \mathord{\left/{\vphantom {{f_{{\text{ H}}_{\text{2}} O}^{\text{V}} } {\left( {f_{{\text{ H}}_{\text{2}} O}^{\text{V}} + {\text{exp}}\left[ { - {\text{3}}{\text{.8389}} - 5025.2\left( {\frac{1}{T} - \frac{1}{{298.15}}} \right)} \right.} \right.}}} \right.\kern-\nulldelimiterspace} {\left( {f_{{\text{ H}}_{\text{2}} O}^{\text{V}} + {\text{exp}}\left[ { - {\text{3}}{\text{.8389}} - 5025.2\left( {\frac{1}{T} - \frac{1}{{298.15}}} \right)} \right.} \right.}} \hfill \\{\text{ }}\left. {\left. { - {\text{ln}}\left( {\frac{T}{{{\text{298}}{\text{.15}}}}} \right) - \left( {\frac{{298.15}}{T} - 1} \right)} \right]} \right) \hfill \\\end{gathered}$$ Application of this formulation to the breakdown reaction of Mg-cordierite to an assemblage of pyrope-sillimanite-quartz±H2O shows that cordierite is stabilized by 3 to 3.5 kbar under H2O-saturated conditions. The thermodynamic properties of H2O in cordierite are similar to those of liquid water, with a standard molar enthalpy and Gibbs free energy of hydration that are the same (within experimental uncertainty) as the enthalpy and Gibbs free energy of vaporization. By contrast, most zeolites have Gibbs free energies of hydration two to four times more negative than the corresponding value for the vaporization of water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307278
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  • 5
    Electronic Resource
    Electronic Resource
    Hepatic UDP-Glucuronosyltransferase in Rainbow Trout (Oncorhynchus mykiss) and Preliminary Assessment of Response to Pulp Mill Cooking Liquor (1999)
    Springer
    Bulletin of environmental contamination and toxicology 62 (1999), S. 608-615 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900918
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  • 6
    Electronic Resource
    Electronic Resource
    Reply (1999)
    Springer
    Skeletal radiology 28 (1999), S. B362 
    Details
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050475
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  • 7
    Electronic Resource
    Electronic Resource
    Testing the Theoretical Fit of an Abseiling Harness: A Study of an Australian Primary and Secondary Prevention Program (1997)
    Springer
    The journal of primary prevention 18 (1997), S. 213-225 
    Details
    ISSN: 1573-6547
    Keywords: prevention ; wilderness ; adolescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A theoretical model of prevention addressing adolescents at-risk of offending was developed then utilised to assess a primary and secondary prevention program. The study of the wilderness-based practise was conducted between September 1992 and October 1994, adopting a pre-post-follow-up quasi-experimental design using waiting periods to establish treatment and control groups. Maturational changes were gauged over a 12 month period of 44 male and 18 female voluntary Australian adolescents between the ages of 15 and 25 years. Significant differences between the treatment and control groups in the psychometric areas of general self-esteem and self-actualisation were found establishing positive program effect on participants. Further, the long term effect of this program in preventing participants initial contact with court proceedings or reducing further involvement respectively, over a twelve month period was substantiated. It was shown that following this experience post program goals of employment and education for adolescents at-risk were positively influenced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1024642508725
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  • 8
    Electronic Resource
    Electronic Resource
    Increased daylength stimulates plasma growth hormone and gill Na+, K+-ATPase in Atlantic salmon (Salmo salar) (1995)
    Springer
    Journal of comparative physiology 165 (1995), S. 245-254 
    Details
    ISSN: 1432-136X
    Keywords: Photoperiod ; Smolt ; Ion transport ; Thyroid hormones ; Somatolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Atlantic salmon juveniles reared at constant temperature (9–10°C) were exposed to four photoperiod treatment and sampled every 2 weeks from January through May. Fish reared under normal photoperiod exhibited eight-and three fold increases in plasma growth hormone and gill Na+, K+-ATPase activity, respectively, between January and April. Fish exposed to abrupt increases in daylength (LD 15:9) in February or March responded with earlier increases in plasma growth hormone and gill Na+, K+-ATPase activity, and earlier decreases in condition factor relative to fish in the normal photoperiod group. Fish maintained under short daylength (LD 9:15) from January to May exhibited delayed and muted increases in plasma growth hormone and gill Na+, K+-ATPase activity. Plasma thyroxine exhibited a 2.5-fold increase from February to late March in the normal photoperiod group, was generally lower in the LD 9:15 group, but exhibited no obvious response to abrupt increases in daylength. There was an increase in plasma 3,5,3′-triiodo-l-thyronine with time in all groups (43–80%) but no significant response to photoperiod. Plasma levels of somatostatin-25 were highest in the LD 9:15 group, but there was no detectable response to increased daylength in any of the photoperiod treatments. The results indicate that plasma growth hormone is responsive to increased daylength and may be causally related to subsequent increases in gill Na+, K+-ATPase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00367308
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