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  • 1
    Electronic Resource
    Electronic Resource
    A nearly optimal deterministic parallel Voronoi diagram algorithm (1996)
    Springer
    Algorithmica 16 (1996), S. 569-617 
    Details
    ISSN: 1432-0541
    Keywords: Voronoi diagram ; Parallel algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We describe ann-processor,O(log(n) log log(n))-time CRCW algorithm to construct the Voronoi diagram for a set ofn point-sites in the plane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944352
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  • 2
    Electronic Resource
    Electronic Resource
    Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 9 (1995), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Successful treatment of Helicobacter pylori infection results in cure of peptic ulcer disease. Multidrug regimens are needed to cure this infection. We studied the effectiveness and side effect profile of two antibiotics active against Helicobacter pylori, metronidazole and clarithromycin, combined with omeprazole. Methods: We evaluated a combination therapy for H. pylori infection consisting of metronidazole (500 mg b.d.), omeprazole (20 mg b.d.), and clarithromycin (250 mg b.d.) for 2 weeks, followed by ranitidine 300 mg daily for 4 weeks. Results: Thirty-three patients with documented H. pylori infection were studied. Twenty had previously failed antimicrobial therapy, including one with metronidazole-based triple therapy and eight with macrolide-based therapy (five with clarithromycinbased therapy), and 11 with amoxycillin, tetracycline, and bismuth. H. pylori status was determined by histopathology using the Genta stain and by culture. H. pylori status was determined at entry and 4 weeks after completing antimicrobial therapy. The H. pylori infection was cured in 88% (95% CI = 72%–96%) including 90% of those who had failed previous anti-H. pylori therapies. Mild side effects were reported by 18%. Conclusion: We conclude that the combination of metronidazole, omeprazole and clarithromycin is an effective treatment for H. pylori infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1995.tb00374.x
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  • 3
    Electronic Resource
    Electronic Resource
    High-dose proton pump inhibitor plus amoxycillin for the treatment or retreatment of Helicobacter pylori infection (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The combination of 120 mg of omeprazole (40 mg t.d.s.) and amoxycillin has been reported to be effective for treating H. pylori infections. Methods: Normal volunteers with H. pylori infection received high-dose omeprazole (40 mg t.d.s.) or lansoprazole (60 mg t.d.s.) plus amoxycillin 750 mg t.d.s. for 14 days. The studies were open label and not randomized as those receiving omeprazole plus amoxycillin had previously failed lower dose omeprazole (20 mg b.d.) plus amoxycillin therapy more than 6 months previously. Those receiving lansoprazole plus amoxycillin had not been previously treated. Four to 6 weeks after ending antimicrobial therapy, H. pylori status was determined by Genta stain of gastric mucosal biopsies. Results: Forty-three volunteers entered the study and 41 completed it. The overall success with high-dose proton pump inhibitor plus amoxycillin was 34.9%. For the individual regimens the per-protocol results were 48% (95% CI=28–69%) with lansoprazole and 12.5% (95% CI=2–38%) with omeprazole. Compliance was 〉95% for both regimens. Side-effects were experienced by four lansoprazole and three omeprazole subjects, and caused two omeprazole subjects to withdraw. Cure rates were similar among different races and ethnic groups, between men and women, and between smokers and non-smokers. The level of the pre-treatment urea breath test also did not predict outcome. Conclusion: High-dose proton pump inhibitor plus amoxycillin combinations for treatment of H. pylori infection yielded unacceptable results, as the 95% confidence intervals did not include an 80% cure rate. These combinations do not yield consistent results worldwide and cannot be recommended as primary therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.77248000.x
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  • 4
    Electronic Resource
    Electronic Resource
    Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy) (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Multi-drug regimens are generally required to reliably cure Helicobarter pylori infection. Metronidazole, clarithromycin and omeprazole has proven to be an effective combination therapy with a cure rate of 90% or greater. Methods: We evaluated a 14-day combination regimen for H. pylori infection consisting of metronidazole 500 mg b.d., clarithromycin 250 mg b.d. and ranitidine 300 mg b.d. (MRC) instead of omeprazole. Ranitidine alone was continued for an additional 4 weeks. H. pylori status was determined by rapid urease testing. histopathology using the Genta stain, and by culture at entry and 4 weeks after completing antimicrobial therapy. Results: Twenty-seven patients with documented peptic ulcer disease and H. pylori infection were treated. Five had previously failed macrolide-based antimicrobial therapy: none had received metronidazole. All ulcers were healed at week 6 except one patient taking naproxen; his H. pylori infection was cured. Overall, H. pylori infection was cured in 78% (95% CI = 58–91%). In patients with clarithromycin-sensitive isolates, the cure rate was 20 of 23 (87%, 95% C.I. = 66–97%); only one of four patients (25%) with clarithromycin-resistant isolates was cured. In contrast, four of five patients with metronidazole-resistant isolates were cured (80%). In patients with isolates sensitive to both antibiotics, the cure rate was 16 of 18 (89% 95% C.I. = 65–99%). Mild side effects were reported by 27%, including diarrhoea and altered taste. Compliance averaged 98%. Conclusion: These results suggest that the combination of metronidazole, ranitidine and clarithromycin results in high cure rates in patients with clarithromycin-sensitive isolates. Omeprazole may not be required for Bazzoli's triple therapy; and large multicentre comparative trials are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1996.tb00185.x
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  • 5
    Electronic Resource
    Electronic Resource
    Free tissue transfer in patients over 75 with head and neck malignancy (1998)
    Springer
    European journal of plastic surgery 21 (1998), S. 303-307 
    Details
    ISSN: 1435-0130
    Keywords: Key words Head and neck ; Elderly ; Malignancy ; Free tissue transfer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Radical excision and reconstruction, often with free tissue transfer, has been shown to offer the best hope of cure for advanced head and neck malignancy. Despite the fact that these patients are often elderly, with significant preoperative morbidity there have been few, if any, reports of the success of excision and free tissue reconstruction in patients over 75 years old. We therefore performed a consecutive review of 12 patients over 75 undergoing such surgery in this unit over the past three years in an effort to clarify indications, success rate and complications. The age of the patients ranged from 75 to 88 years (mean 81). All of the flaps survived. Two (16%) required early reexploration. Six of the twelve (50%) patient remain tumour free an average of 18.3 months after surgery (range 1–33 months). One died of causes unrelated to his tumour 14 months after surgery. Of the remaining five, two died in the early post-operative period, two of recurrent tumour or a second primary and one remains alive 8 months post-surgery despite local reccurrence. We dicuss the indications, complications and outcomes of surgery in these cases and discuss patient selection and measures which may help reduce peri-operative morbidity and mortality in these elderly patients undergoing radical surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002380050102
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  • 6
    Electronic Resource
    Electronic Resource
    Spatial and temporal population structure of Brevicoryne brassicae (1996)
    Springer
    Entomologia experimentalis et applicata 78 (1996), S. 121-127 
    Details
    ISSN: 1570-7458
    Keywords: Brevicoryne brassicae ; cellulose acetate ; electrophoresis ; allozyme variation ; population structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Allozymes from individual aphids were used as markers to examine the structure of Brevicoryne brassicae colonies collected from field experiments at Horticulture Research International, Wellesbourne, during the summers of 1991, 1992 and 1993. Eighteen enzyme systems were examined using cellulose acetate electrophoresis, but only 6-phosphogluconate dehydrogenase (6-PGDH) showed polymorphism (three alleles) in the samples. There were significant differences in gene frequencies between populations at some sites within 1 kilometre and between times of sampling, with an increase in the proportion of the most common genotype AA later in the season, possibly due to selection during the summer of the best adapted clones. These changes in gene frequency might produce biased results in trials screening brassica crops against aphids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187507
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  • 7
    Electronic Resource
    Electronic Resource
    Low aromatic amino acid concentrations in leaf proteins determine resistance to Frankliniella occidentalis in four vegetable crops (1996)
    Springer
    Entomologia experimentalis et applicata 78 (1996), S. 325-333 
    Details
    ISSN: 1570-7458
    Keywords: Western flower thrips ; host plant resistance ; Capsicum annuum ; Cucumis sativus ; Lactuca sativa ; Lycopersicon esculentum ; indirect selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Analysis of total aromatic amino acid (free and bound) in some cucumber accessions selected previously for resistance to western flower thrips, Frankliniella occidentalis (Pergande) [Thysanoptera: Thripidae], indicated that low concentrations of these essential nutrients, relative to total leaf protein, were correlated with a reduction in damage by the insect. Further analysis of samples of four important horticultural crops (lettuce, tomato, pepper and cucumber) with unknown levels of resistance to thrips showed a significant genotypic variation in the concentrations of total aromatic amino acids relative to the total leaf protein. Accessions from each crop with low or high concentrations of aromatic amino acids in proteins were exposed to thrips larvae. Regression analysis showed a highly significant positive correlation between aromatic amino acid concentration in leaf protein and thrips damage, regardless of crop species. It is concluded that higher concentrations of aromatic amino acids in plant proteins are important for successful thrips development. These results provide plant breeders with a promising tool for indirect selection without using undesirable insect bioassays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193452
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  • 8
    Electronic Resource
    Electronic Resource
    The relative importance of glucosinolates and amino acids to the development of two aphid pests Brevicoryne brassicae and Myzus persicae on wild and cultivated brassica species (1997)
    Springer
    Entomologia experimentalis et applicata 85 (1997), S. 121-133 
    Details
    ISSN: 1570-7458
    Keywords: Brevicoryne brassicae ; Myzus persicae ; Brassica fruticulosa ; B. spinescens ; B. juncea ; B. nigra ; B. carinata. B. macrocarpa ; B. villosa var drepanensis ; B. oleracea ; B. napus ; B. campestris ; host-plant resistance ; glucosinolates ; amino acids ; leaf water potential ; generalist ; specialist ; aphids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper describes an experiment to investigate the relative importance of glucosinolates and the availability of free amino acids in the phloem to the feeding behaviour and development of the specialist brassica aphid, Brevicoryne brassicae (L) (cabbage aphid) and the generalist, Myzus persicae, (Sultzer) (peach potato aphid). Aphid development was determined on brassica species and cultivated brassica varieties. Analysis of individual glucosinolates in the wild brassica species identified significant differences in their profiles and in their concentrations present in freeze dried leaves. Multiple regression analysis showed a significant correlation ( $$\left( {r = 0.83} \right)$$ ) between the intrinsic rate of increase of B. brassicae and glucosinolate concentrations; four glucosinolates, 2-OH-3-butenyl, and 2-propenylglucosinolate, 3-methoxyindolyl and 4-pentenylglucosinolates accounted for 79% of the variation. The intrinsic rate of increase of M. persicae was less correlated, though still significant ( $$\left( {r = 0.5} \right)$$ ); 3-indolyglucosinolate and 3-butenylglucosinolate accounted for 47% of the variation. Regression analysis also showed a correlation between phloem amino acid concentrations and the intrinsic rate of increase of B. brassicae ( $$\left( {r = 0.48} \right)$$ ) but not of M. persicae. The concentration of the important amino acids tyrosine, alanine, leucine and glutamic acid, accounted for 43% of the variation in intrinsic rate of increase. Leaf water potential of the Brassica species showed no relationship with the intrinsic rate of increase of either B. brassicae or M. persicae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003049105464
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of feeding behaviour of two Brassica pests Brevicoryne brassicae and Myzus persicae on wild and cultivated brassica species (1997)
    Springer
    Entomologia experimentalis et applicata 85 (1997), S. 135-143 
    Details
    ISSN: 1570-7458
    Keywords: Brevicoryne brassicae ; Myzus persicae ; Brassica juncea ; B. nigra ; B. carinata ; B. macrocarpa ; B. villosa var. drepanensis ; B. oleracea ; B. campestris B. napus ; B. rapa ; host-plant resistance ; electronic monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Feeding behaviour of the specialist Brassicae aphid, Brevicoryne brassicae (L) (cabbage aphid) and the generalist, Myzus persicae, (Sulzer) (peach potato aphid) was monitored electronically on the susceptible cauliflower, Brassica oleracea var. botrytis cv Newton Seale, and a range of 17 Brassica species, B. carinata, B. juncea, B. nigra, B. macrocarpa, and B. villosa var. drepanensis and cultivated brassica varieties, B. oleracea, B. campestris and B. napus. Aphids, monitored for 10 h on the underside of leaves, performed recognisable feeding behaviour on all brassica species. The main differences in feeding behaviour, between M. persicae and B. brassicae, on the susceptible cauliflower Newton Seale, were fewer probes, shorter times to initially reach the phloem but longer times to establish sustained phloem ingestion and the longer times spent, by M. persicae, in xylem ingestion. Feeding behaviour on the range of brassica species tested indicated that generalist and specialist aphids are influenced differently by the host plant. A longer time spent in xylem ingestion was again the major difference in the feeding behaviour of the two aphids. In addition, rejection of passive phloem ingestion, by M. persicae, was not related so closely to increased time spent in non probing activities, as for B. brassicae. This observation indicates that M. persicae does not generally accept or reject brassica species due to the presence of phagostimulants, such as glucosinolates at the leaf surface or along the stylet pathway, unless the concentration is very high. Differences in feeding strategies employed by generalist and specialist aphids on the same plants are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003188103050
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  • 10
    Electronic Resource
    Electronic Resource
    The role of data networking in the management of BT's SDH network (1998)
    Springer
    BT technology journal 16 (1998), S. 171-181 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract This paper outlines the history behind the current realisation of the management data communications network for synchronous digital hierarchy (SDH), explaining the various international standards inputs, supplier implementations and illustrating the architecture employed. Message addressing methods are discussed together with the protocols over which they are used. The dimensioning of this network is a key issue of ongoing discussion and impacts the provisioning rates and response times for SDH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009693226423
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