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  • 1
    Electronic Resource
    Electronic Resource
    A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle (1999)
    Springer
    Diabetologia 42 (1999), S. 151-159 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Euglycaemic insulin clamp ; insulin sensitizer ; isoxazolidinedione ; insulin signaling ; JTT-501
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A newly synthesized antidiabetic agent, JTT-501 is an isoxazolidinedione rather than a thiazolidinedione. An oral dose of JTT-501 (100 mg · kg–1· day–1) given to 12-week-old male Zucker fatty rats for 7 days led to the amelioration of both hyperinsulinaemia (40 % of non-treated) and hypertriglyceridaemia (23 % of non-treated) as well as a 2.4-fold increased insulin sensitivity as determined by a euglycaemic insulin clamp. In our study, we further evaluated the acute effect of JTT-501 on both the glucose infusion rates (GIR) and insulin signalling in skeletal muscle. Male Sprague-Dawley (SD) rats aged 10 weeks were injected intravenously with JTT-501 (5 mg/kg) and then a euglycaemic insulin clamp was initiated and glucose infusion rates monitored for 150 min. We found that this treatment increased the glucose infusion rate by 33 % during the last 30 min in SD rats. After the clamp had been initiated for 30 min, the insulin-stimulated phosphatidylinositol 3-kinase (PI3-kinase) activities co-immunoprecipitated with insulin receptor substrate 1 (IRS-1) were also enhanced, resulting in increased glycogen synthase activities in the soleus muscles. Treatment with JTT-501 also enhanced the phosphorylation of insulin receptors and insulin receptor-substrate 1 rapidly as well as the phosphatidylinositol 3-kinase activities, which were stimulated by a bolus injection of insulin. Similarly, JTT-501 stimulated the glucose infusion rate by 30 % and enhanced insulin signalling in Zucker fatty rats. In conclusion, a newly developed isoxazolidinedione, JTT-501, rapidly potentiates the insulin sensitivity of skeletal muscle by enhancing insulin signalling and could be useful for the treatment of insulin-resistant diabetic subjects. [Diabetologia (1999) 42: 151–159]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051133
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  • 2
    Electronic Resource
    Electronic Resource
    Fan-shaped hepatic parenchymal damage after ethanol injection therapy for hepatocellular carcinoma: MRI appearances (1999)
    Springer
    Abdominal imaging 24 (1999), S. 56-60 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Magnetic resonance imaging (MRI)—Liver—Hepatocellular carcinoma—Percutaneous ethanol injection therapy—Parenchymal damage.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: T1- and T2-weighted magnetic resonance (MR) images frequently show fan-shaped areas of hypo- or hyperintensity in the hepatic parenchyma adjacent to a treated hepatocellular carcinoma after percutaneous ethanol injection (PEI) therapy. These areas correspond to abnormal contrast enhancement on serial dynamic MR images. The purpose of the present study was to describe the location, appearance, and frequency of these abnormalities because it is important to understand these entities for the correct assessment of therapeutic efficacy. Methods: MR imaging including a multisection dynamic study was performed in 20 consecutive patients with hepatocellular carcinoma treated with PEI therapy. We retrospectively evaluated the presence of fan-shaped hypointensities adjacent to treated tumors in the liver parenchyma on T1-weighted images and hyperintensities on T2-weighted images and corresponding fan-shaped contrast enhancement on both arterial-dominant and delayed-phase dynamic MR images. We review the location, appearance, and frequency of these findings, and we discuss the possible causes on the basis of pathologic examinations. Results: Seven (35%) of the 20 patients showed fan-shaped hyperintense areas adjacent to the treated tumors on T2-weighted images. These areas showed isointensity in five patients and hypointensity in two patients on T1-weighted images. Of these seven patients, one (14%) underwent the MR imaging within 1 month after the completion of PEI therapy, and six (86%) had it 2–9 months after the completion of PEI therapy (mean = 6 months). In all seven patients, fan-shaped hyperperfusion abnormalities corresponding to these areas of hyperintensity on T2-weighted images were seen on both arterial-dominant and delayed-phase dynamic MR images. Pathologically, the coagulative necrosis of the hepatocytes with sinusoidal dilatation and the restoration by the development of fibrous tissue were seen in these fan-shaped areas. Conclusion: The fan-shaped areas of abnormal intensity on T1- and T2-weighted images and contrast enhancement on dynamic MR images seem to be attributable to pathologic changes in the normal liver parenchyma induced by the toxic reaction of ethanol. Awareness of the occurrence of such abnormalities in the peripheral liver parenchyma adjacent to the treated tumor is important for the correct assessment of therapeutic efficacy. RID=""ID=""〈e5〉Correspondence to:〈/e5〉 T. Fujita
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900440
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  • 3
    Electronic Resource
    Electronic Resource
    Homogeneous enhancement of hepatic parenchyma: MR imaging during arterial portography versus CT during arterial portography (1998)
    Springer
    Abdominal imaging 23 (1998), S. 51-55 
    Details
    ISSN: 1432-0509
    Keywords: Key words: MR during arterial portography—CT during arterial portography—Liver—Gadolinium.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The goal of this study was to investigate the frequency of inhomogeneous parenchymal enhancement of the liver in magnetic resonance imaging during arterial portography (MRAP) versus computed tomography during arterial portography (CTAP). Methods: CTAP and MRAP were performed in 29 and in 21 patients, respectively, who had suspected primary or secondary liver tumors on clinical or biological grounds. We evaluated the frequency of inhomogeneous hepatic parenchymal enhancement not related to a decrease of portal blood supply due to compression or obstruction by the tumor and physiologic variation in portal perfusion. Inhomogeneous parenchymal enhancement of the liver was classified as segmental or subsegmental and as nonsegmental. Results: Segmental or subsegmental inhomogeneous parenchymal enhancement was seen in six of 29 patients (20.1%) on CTAP and in one of 21 patients (4.8%) on MRAP. Nonsegmental inhomogeneous parenchymal enhancement was seen in five of 29 patients (17.2%) on CTAP images and in none of the patients (0%) on MRAP images. The incidence of nonsegmental inhomogeneous parenchymal enhancement was significantly lower on MRAP than on CTAP. Conclusion: MRAP was superior to CTAP in achieving homogeneous parenchymal enhancement of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900284
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  • 4
    Electronic Resource
    Electronic Resource
    Hepatic perfusion abnormalities in acute pancreatitis: CT appearance and clinical importance (1999)
    Springer
    Abdominal imaging 24 (1999), S. 157-162 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Pancreas—Liver, computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of the present study was to describe the computed tomography (CT) appearances of transient hepatic attenuation differences (THADs) in patients with acute pancreatitis and to discuss the mechanism of THAD. Methods: Two-phase dynamic CT images of 28 patients with acute pancreatitis were reviewed. Among them, THAD was seen in nine patients. All patients underwent ultrasonography, and four patients with THAD underwent surgery. Results: Three types of THAD (THAD adjacent to the gallbladder in five of 28 patients, THAD with left lobar distribution in three of 28, wedge-shaped THAD in one of 28) were seen on the two-phase dynamic CT scans of patients with acute pancreatitis. In five patients, THAD disappeared when acute pancreatitis had subsided. Conclusions: THAD in acute pancreatitis is probably caused by increased arterial blood flow attributable to the inflamed lobe of the liver or the inflamed gallbladder. THAD in acute pancreatitis should not be confused with primary liver abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900466
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  • 5
    Electronic Resource
    Electronic Resource
    Cellular Dynamics of Macrophages and Microglial Cells in Reaction to Stab Wounds in Rat Cerebral Cortex (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 275-279 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Cortical stab wound; macrophages; microglial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To examine the cellular dynamics of macrophages and microglial cells in response to cerebral injury, we studied the brain adjacent to cortical stab wounds in young adult rats. Brains were obtained 30 min after intravenous infusion of bromodeoxyuridine (BrdU) on one day (day 1) to 28 days (day 28) after wounding. Brain sections were double-labelled immunohistochemically for monocyte/macrophage antigen ED1 and for BrdU. ED1-positive (ED1+) cells were classified morphologically into two groups, ED1+L and ED1+S cells, representing macrophages and microglial cells, respectively. ED1+L cells appeared on day 1 after wounding and rapidly increased in number to reach a maximum on day 3, but quickly disappeared by day 5. ED1+S cells also appeared on day 1, but the increase in number was slower, reaching a maximum only on day 7. ED1+L cells were all negative for BrdU, but some ED1+S cells were stained for BrdU, evidence of proliferation. The present investigation demonstrated different cellular dynamics for macrophages and microglial cells responding to a stab wound, and also indicated differing sources for the two cell type. It may be possible to prevent the accumulation of these cells which are harmful to the brain in reducing the damage suffered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050095
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  • 6
    Electronic Resource
    Electronic Resource
    Complement activation via lectin pathway in IgA nephropathy (1999)
    Melbourne, Australia : Blackwell Science Asia Pty. Ltd.
    Nephrology 5 (1999), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.1999.00089.x
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of carrier-trapping phenomena in ultrathin chemical oxides using x-ray photoelectron spectroscopy time-dependent measurements (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 74 (1999), S. 2011-2013 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report a technique to characterize carrier-trapping phenomena in SiO2 by measuring the Si 2p core-level energy of Si substrates covered with thin SiO2 layers as a function of x-ray irradiation time. It is found that the Si 2p peak energy, which corresponds to the band bending at the SiO2/Si interface, changes as the x-ray irradiation time increases. We attribute this to carrier-trapping phenomena in SiO2. By using this technique, it is found that the carrier-trapping phenomena differ remarkably among several chemical oxides. We also discuss the atomic structure of the traps that cause the trapping phenomena. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.123730
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  • 8
    Electronic Resource
    Electronic Resource
    Flautist's chin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1997.tb08778.x
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  • 9
    Electronic Resource
    Electronic Resource
    Immunochemical detection of precursor proteins of yolk and vitelline envelope, and their annual changes in the blood of Diodon holocanthus (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 52 (1998), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Two distinct groups of female-specific proteins, vitellogenin (VTG) and vitelline envelope proteins (VEP), were detected in the blood of the porcupine fish Diodon holocanthus, and annual changes in concentration were measured immunochemically. Using antisera against yolk proteins (ab.a-E) and VEP (ab. a-VEP), VTG and VEP could be detected in the blood of maturing female fish and oestradiol-17β (E2)-treated fish. Neither protein was detected in the blood of male fish. Immunohistochemistry showed that yolk globules and the vitelline envelope enclosing developing oocytes stained with ab.a-E. The vitelline envelope was stained specifically with ab.a-VEP. Hepatocytes from the E2-treated fish had immunoreactivity with both antisera. Thus, VTG and VEP appear to be synthesized in the liver by direct stimulation of E2, released into the circulation, and incorporated into respective target sites. VTG and VEP in female serum maintained high levels from April until June, suggesting that yolk accumulation, as well as vitelline envelope formation, are occurring actively during these months. Unlike VTG, small amounts of VEP were detected between December and March, suggesting that vitelline envelope formation precedes yolk accumulation and that a slightly different hormonal regulation exists in the synthesis of both proteins in the liver during the early phase of oogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1998.tb00968.x
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  • 10
    Electronic Resource
    Electronic Resource
    Two Cobaltacyclopentadiene Complexes and One Cyclobutadiene Complex (1995)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 2265-2269 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270195005993
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