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Time-resolved measurement of single-electron tunneling in a Si single-electron transistor with satellite Si islands (1995)

Fujiwara, A. ; Takahashi, Y. ; Murase, K. ; [et al.]

Woodbury, NY : American Institute of Physics (AIP)

Applied Physics Letters 67 (1995), S. 2957-2959

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ISSN: 1077-3118

Source: AIP Digital Archive

Topics: Physics

Notes: A Si single-electron transistor (SET) with satellite Si islands has been fabricated by pattern-dependent oxidation of cross-shaped Si wires on a separation by implanted oxygen (SIMOX) substrate. The oscillatory conductance-versus-gate voltage characteristics of the SET show hysteresis as a result of abrupt jumps in the conductance at high temperatures around 30 K. This phenomenon is attributed to the memory effect of a single electron that tunnels between the SET Si island and the satellite Si islands. Time-resolved measurements have clarified that the conductance jump is a Poisson process, which is clear evidence of the single-electron tunneling between the Si islands. © 1995 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.114824

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Determination of the immunosuppressive drug tacrolimus in its dosage forms by high-performance liquid chromatography (1995)

Namiki, Y. ; Fujiwara, A. ; Kihara, N. ; [et al.]

Springer

Chromatographia 40 (1995), S. 253-258

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ISSN: 1612-1112

Keywords: Column Liquid Chromatography ; Immunosuppessive drug FK 506 (Tacrolimus) ; Tautomeric Phenomenon

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary A high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of FK506, a new immunosuppressant, in bulk drug samples and dosage forms. Equilibration between FK506 (I) and its tautomeric compounds (II and III) was accomplished “artificially” in water-dehydrated alcohol (1∶1) employed as an extraction solvent. After reaching equilibrium, separation of I, treated as the representetive of equilibrated FK506, from its related substances was achieved by reversed-phase HPLC on a C18 column with water-isopropyl alcohol-tetrahydrofuran (5∶2∶2, v/v) as the mobile phase, and detection at 220 nm. Component I in dosage forms could be recovered satisfactorily and determined with good precision. The calibration graph was linear over the range 2–6 μg for I.