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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Hyperosmotic Solutions on Human Brain Tumour Vasculature (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1135-1142 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Blood-brain barrier; microcirculation; metastatic brain tumour; tumour vasculature.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Reversible opening of the blood-brain barrier (BBB) has been used to increase delivery of chemotherapeutic agents into brain tumours, but it is complicated and requires general anaesthesia. Without affecting the normal BBB, and avoiding the complications of BBB modification by hyperosmotic solution, we tried an adequate minimal BBB disruption in brain tumours. Although the effect of BBB disruption on normal brain has been described, there are no reports of the effect of an impaired BBB on microcirculation. In this study, four patients underwent surgical resection of a glioblastoma multiforme (GM; n=1), astrocytoma (n=2), or metastatic brain tumour (n=1). Epicerebral microcirculation was observed in the operative field. Serial fluorescein microangiograms of the tumour and peritumoural area were obtained before and after BBB disruption was introduced intra-operatively by retrograde infusion of mannitol introducing a catheter via the temporal superficial artery back to the carotid bifurcation. On the initial microangiogram, staining by the fluorescein dye was observed in the GM and metastatic tumour but not in the astrocytoma; no extravasation of fluorescein dye was observed in the peritumoural areas. After BBB disruption, fluorescein perfusion increased and extravasation of fluorescein dye from the venules was observed in the GM and the metastatic tumour and in the peritumoural area of both lesions; BBB disruption started from venules in the peritumoural area without affecting the normal brain. However, such effects were not observed in the astrocytomas after BBB disruption nor in normal brain tissue in any patient. It appears that the integrity of the BBB is less stable in the peritumoural area of GM and metastatic brain tumours than it is in astrocytomas or normal brain. Osmotic BBB disruption may offer a method for achieving global delivery of therapeutic agents to brain tumours and peritumoural areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050227
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  • 2
    Electronic Resource
    Electronic Resource
    Trichogenic trichoblastoma arising on the supraclavicular fossa with an immunohistochemical study of cytokeratin expression (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 22 (1997), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 52-year-old female with trichogenic trichoblastoma arising on the supraclavicular fossa. Clinical and histological examinations revealed a thumbnail sized, elastic, hard, subcutaneous nodule which consisted of keratinous cysts and epithelial cords of basaloid cells with locally follicular differentiation. Based on histological observations, a diagnosis of trichogenic trichoblastoma was made. An immunohistochemical study using a panel of monoclonal antibodies against cytokeratins was performed to investigate the nature and differentiation of this tumour. The most characteristic findings of the immunohistochemistry were CK 8 and 19 expression in the epithelial cords and the outer cells of the cystic structures. These immunoreactivities were similar to those of the outermost layer of the outer root sheath between the lower permanent portion and the upper transient portion, and immunostaining with the other antibodies confirmed this similarity. We can speculate that trichogenic trichoblastoma differentiates mainly toward the outermost layer of the outer root sheath between the lower permanent portion and the upper transient portion, and then into follicular structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1997.tb01058.x
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  • 3
    Electronic Resource
    Electronic Resource
    Intergranular transport properties in c-axis oriented YBa2Cu3Oy polycrystalline films (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 2367-2369 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The current–voltage (I–V) characteristics and the resistive transition under magnetic field were extensively investigated on c-axis oriented YBCO polycrystalline films with a different amount of an in-plane grain alignment. All the parameters deduced from the scaling analyses in the intergranular region along with the vortex-glass-to-liquid transition indicate that the intergranular current transport is not via weak links but is due to strongly coupled channels regardless of a degree of an in-plane grain alignment. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.120430
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  • 4
    Electronic Resource
    Electronic Resource
    A flow cell suitable for time-resolved X-ray crystallography by the Laue method (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 30 (1997), S. 555-556 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A low-cost flow cell was produced using a commercially available T-shaped connector and used for collecting Lane diffraction data. Since this flow cell can be easily constructed within a few minutes, it is suitable for Lane experiments at synchrotron laboratories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889897098944
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  • 5
    Electronic Resource
    Electronic Resource
    A molecular dynamics-aided fracture mechanics parameter and its application to a tensile problem (1995)
    Springer
    Computational mechanics 16 (1995), S. 217-222 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  To evaluate fracture by a single parameter like J integral in molecular dynamics (MD) calculation, we propose a parameter derived by extending ĵ integral to atomic model, being referred to as H-sum. To examine the path independence of H, we first apply H to a simple tensile problem of two dimensional model of α-iron by using molecular dynamics method. As a result, we confirm that H has the path independence within an accuracy of 8.5. In addition, the validity of the proposed parameter is clarified by analyzing a problem of microscopic crack initiation and propagation process. H increases with increasing tensile stress and reaches a critical value when a crack initiates, and subsequently decreases with the crack growth. Calculating K IC from this critical H, we compare K IC with deCelis’and the Mullins’results calculated directly from MD calculation, and get good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369866
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  • 6
    Electronic Resource
    Electronic Resource
    A molecular dynamics-aided fracture mechanics parameter and its application to a tensile problem (1995)
    Springer
    Computational mechanics 16 (1995), S. 217-222 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract To evaluate fracture by a single parameter like J integral in molecular dynamics (MD) calculation, we propose a parameter derived by extending Ĵ integral to atomic model, being referred to as H-sum. To examine the path independence of H, we first apply H to a simple tensile problem of two dimensional model of α-iron by using molecular dynamics method. As a result, we confirm that H has the path independence within an accuracy of 8.5%. In addition, the validity of the proposed parameter is clarified by analyzing a problem of microscopic crack initiation and propagation process. H increases with increasing tensile stress and reaches a critical value when a crack initiates, and subsequently decreases with the crack growth. Calculating K IC from this critical H, we compare K IC with deCelis' and the Mullins' results calculated directly from MD calculation, and get good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369866
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  • 7
    Electronic Resource
    Electronic Resource
    Biological responses inCaenorhabditis elegans to high magnetic fields (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 284-288 
    Details
    ISSN: 1420-9071
    Keywords: Alternating high magnetic fields ; eddy current ; magnetic flux concentration ; Caenorhabditis elegans ; growth ; reproduction ; behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Here we describe a device for testing possible influences of high magnetic fields on biological processes, by which alternating-current magnetic stimuli as high as 1.7 T can be administered. Experiments with a simple multicellular organism, the nematodeCaenorhabditis elegans, revealed that intermittent exposure to the magnetic fields modestly inhibited the animal's reproduction as well as its post-embryonic development, and caused a marked but transient derangement in its locomotory behavior. Available evidence indicates that alternating high magnetic fields can elicit both chronic and acute biological effects, but that the effects may be well tolerated or compensated for by the living organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01931113
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  • 8
    Electronic Resource
    Electronic Resource
    Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 224-226 
    Details
    ISSN: 1437-1596
    Keywords: Key words Population study ; HUMFES ; HUMVWA ; HUMF13A01 ; D1S80 ; Philippines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Allele frequency distributions at the short tandem repeat (STR) loci HUMVWA, HUMFES, HUMF13A01 and of the variable number of tandem repeat (VNTR) locus D1S80 were determined in a Filipino population from Metro Manila (103 individuals) by use of the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE). The exact test demonstrated that all four loci had no deviations from Hardy-Weinberg equilibrium (HWE) with the only reservation that the exact test p-value for F13A01 is weak. The discriminating power is 0.82 for D1S80, and the expected exclusion chance is 0.85 for F13A01, 0.83 for FES, and 0.93 for VWA. The observed heterozygosity rates are 0.63 for D1S80, 0.66 for F13A01, 0.67 for FES, and 0.80 for VWA. The exact test for independance between all loci gave a p-value of 0.0195. This is the first time that Filipino population data of DNA loci of forensic importance are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050157
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  • 9
    Electronic Resource
    Electronic Resource
    Novel variants in the promoter region of the CREB gene in schizophrenic patients (1999)
    Springer
    Journal of human genetics 44 (1999), S. 428-430 
    Details
    ISSN: 1435-232X
    Keywords: Key words cAMP-responsive element-binding protein ; Transcription factor ; Promoter ; Variant ; Schizophrenia ; Clinical characteristics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used by most dopamine and serotonin receptor subtypes. In addition, CREB stimulates the expression of a number of genes, alterations in the expression of which may be associated with schizophrenia. The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia. Eighty unrelated schizophrenics and 100 healthy controls were screened for genetic variants of the CREB gene by SSCP analysis, followed by direct sequencing of PCR products. Two novel variants (−933T?C and −413G?A) were found only in schizophrenics. A patient with the −933T?C variant had unusual clinical characteristics in addition to typical schizophrenic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050196
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