ISSN:
1432-1912
Keywords:
Key words Angiotensin II
;
Telmisartan
;
Vascular conductance
;
Vasoconstriction
;
Left gastric artery
;
Femoral artery
;
Vasopressin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In the present study the effects were examined of the non-peptide angiotensin II AT1 receptor antagonist, telmisartan, and of angiotensin II on the vascular conductance in the left gastric and the femoral arterial bed of anaesthetized rats. Blood flow was recorded with the ultrasonic transit time shift technique and vascular conductance was calculated as blood flow divided by mean arterial blood pressure. I.v. injection of angiotensin II (1 nmol kg-1) led to a transient fall of gastric arterial conductance, while femoral arterial conductance was not altered. Telmisartan (1 mg kg-1, i.v.) increased vascular conductance in the left gastric, but not femoral, arterial bed and inhibited the constrictor response of the left gastric artery to angiotensin II. The ability of arginine-vasopressin (0.3 nmol kg-1, i.v.) to cause hypertension and to constrict the left gastric and the femoral artery was not influenced by telmisartan. These data indicate that the angiotensin II antagonist telmisartan dilates the gastric, but not femoral, arterial bed of the rat and point to a constrictor role of endogenous angiotensin II in the gastric vasculature.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171330
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