ISSN:
1573-1111
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Chloramphenicol palmitate (CPP) was converted to an amorphous complex when spray-dried with 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), and no crystallization of CPP was observed for at least 2 months under the storage condition of 50°C and 50% relative humidity. The dissolution rate of CPP/HP-β-CyD complex in aqueous HCO-60 solution was much faster than CPP polymorphs (complex 〉 metastable forms (B and subB) 〉 stable form (A)), which was reflected in thein-vivo absorption behavior of CPP following oral administration in dogs.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01041561
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