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  • 1995-1999  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Health & social care in the community 6 (1998), S. 0 
    ISSN: 1365-2524
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Most research on children and risk is heavily influenced by developmental theory. This paper is based on a study which uses a different approach, drawing on recent work within the sociology of childhood. ‘Children, Parents and Risk’ explores the ways in which risks to children are understood and managed by children and parents, focusing on children's daily lives in and around the home at the ages of 3, 9 and 12 years. Data were gathered from interviews with children and their parents at home and from children at school and in a youth club. The paper draws on the findings from the study in order to discuss and compare parents' and children's ideas about children and childhood as risk-related; it also aims to examine the findings in the context of Ulrich Beck's recent work on the risk society and individualization. Both parents and children tended to ‘externalize’ risk away from the home and into the outside world. In response to perceived risks to childhood many parents appeared to see their role as that of striking a balance between protection and compensatory provision, and their accounts included details of increasingly ‘individualized’ measures to reduce such risks. The children conceptualized their experiences of adult control as welcoming when preventing the child's exposure to risk but as constraining when it restricted their autonomy. The paper concludes that the findings accord with Beck's description of the ‘risk society’ and that they lend some limited support to Beck's individualization thesis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Key words Enkephalin ; GABA ; Basal ganglia ; 6-Hydroxydopamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In Parkinson’s disease the dopaminergic nigrostriatal pathway degenerates, resulting in an imbalance in activity of two pathways of information flow through the basal ganglia. In animal models of the disease, the striatonigral pathway becomes underactive and the striatopallidal pathway becomes overactive. In the present study immunocytochemistry for enkephalin and GABA and anterograde labelling were used to investigate whether morphological plasticity occurs in striatopallidal terminals following unilateral removal of the nigrostriatal dopaminergic pathway. Pallidal terminals were immunostained to reveal enkephalin and examined in the electron microscope (n=399). Immunoreactive synaptic bouton profiles were on average 64% larger on the experimental side 26 days after the lesion. Analysis of their shape revealed that those on the dopamine-depleted side of the brain were more irregular in profile and that their synaptic specialisations were more complex in shape but not significantly different in length. Striatopallidal terminals were also identified by GABA immunocytochemistry combined with anterograde labelling (n=20). Double-labelled boutons were significantly larger in cross-sectional area on the experimental side (57%). Analysis of terminals that were simply labelled by the immunogold method to reveal GABA (n=278) showed no significant differences in size between terminals from the dopamine-depleted and control side. This suggests that a substantial number of GABAergic terminals in the globus pallidus do not belong to the striatopallidal population of terminals. These morphological changes correlate with previous studies suggesting striatopallidal boutons are more active after destruction of dopaminergic input to the neostriatum.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 261-280 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Resistance ofCandida to azoles is an increasing problem. Susceptibility testing ofCandida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis. The relationship, if any, between resistance and clinical failure in the context of invasive candidiasis is not clear at present and additional correlative work needs to be done. Monitoring of resistance trends inCandida is clearly important now.
    Type of Medium: Electronic Resource
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