ISSN:
1432-1440
Keywords:
Tumor viruses
;
Hepatitis B virus
;
Human papillomavirus
;
Epstein-Barr virus
;
Human T cell leukemia virus 1
;
Tumor suppressor proteins
;
p53
;
Retinoblastoma protein
;
Cell cycle
;
p21
;
Apoptosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Accumulating evidence indicates that tumor viruses represent a major etiological factor in a significant portion of human cancers. These cancers include human papillomavirus induced anogenital cancers, hepatitis B and C virus associated hepatocellular carcinomas, nasopharyngeal carcinomas and lymphomas linked to Epstein-Barr virus infection, and human T cell leukemia virus associated adult T cell leukemias. This review summarizes the recent progress made in understanding the molecular mechanisms of viral carcinogenesis, with a particular focus on the interaction of viral factors with cellular tumor suppressor proteins. The functional inactivation of tumor suppressor proteins may represent a common strategy by which several tumor viruses contribute to malignant cell transformation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00195138
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