Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Confocal fluorescence and Raman microscopy in industrial research (1998)
    Springer
    Colloid & polymer science 276 (1998), S. 577-588 
    Details
    ISSN: 1435-1536
    Keywords: Key words Confocal microscopy ; confocal Raman microscopy ; chemical imaging ; laser scanning confocal microscopy ; two-photon-microscopy ; fluorescence correlation spectroscopy ; Raman correlation spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Modern chemical and pharmaceutical industrial research benefits from improved spectroscopic tools. New developments in confocal fluorescence and Raman microscopy lead to an increase in sensitivity, selectivity and speed of microscopic imaging and fluctuation analysis resulting in a better understanding of structure–property relationships essential for targeted development. In this paper we report on the application of fluorescence and Raman microscopy for characterizing the morphology of polymeric multiphase solid-state samples and on new developments in the corresponding correlation spectroscopies for the characterization of the dynamics of complex colloidal systems in the liquid state. In the case of fluorescence new technological opportunities are gained by two-photon excitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050284
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of Human Tumor Cell Lines on Local New Bone Formation In Vivo (1997)
    Springer
    Calcified tissue international 60 (1997), S. 210 -215 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone formation — Tumor — Calvaria — Growth factor — Histomorphometry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Although some tumors cause osteolytic lesions, there are some that stimulate new bone formation. This is an important phenomenon because the responsible mechanisms probably represent an aberration of normal physiological bone formation, and identifying the factors involved in the process may lead to new therapies for various bone diseases. To clarify our understanding of the potential mechanism responsible, we compared and quantitated the extent of new bone formation stimulated by human tumors (HeLa, Hep-2, AV-3, FL, WISH and KB), some of which have osteogenic activity in vivo [2]. Tumor cells were injected over the calvaria of nude mice to examine formation of new bone. The tumor cells produced three histologically distinct patterns of new bone growth: (1) WISH and KB stimulated appositional bone growth adjacent to periosteal bone surfaces; (2) HeLa and Hep2 induced new bone growth over calvarial surface even when distant from the tumor mass; (3) FL stimulated bone formation adjacent to periosteum as well as ectopic bone formation in sites distant from bone. All tumors except AV3 induced mean new bone thickness 〉100 μm, and Hep-2 cells produced bone 330 μm thick. PCR and Northern blot analysis of mRNA isolated from cultured tumor cells revealed that all cell lines expressed mRNA for TGFβ, (fibroblast growth factor) FGF-1, FGF-2, and IGF-I, and most cell lines produced mRNA for PDGF. Only FL expressed large amounts of mRNA for BMP2. In serum-free conditioned media from Hep2 and HeLa cells purified by heparin affinity chromatography, we have identified FGF-1, FGF-2, and PDGF by immunodetection with specific antibodies. Our results show that new bone growth caused by these tumors is likely due to the production of bone growth factors by the tumor cells, and that the overall effects on bone may be due to several factors working in concert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900216
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mitogenic Lectin Concanavalin A Induces Calvarial Bone Formation In Vivo via Indomethacin-Sensitive Pathway (1997)
    Springer
    Calcified tissue international 60 (1997), S. 204 -209 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone formation — Lectin — Concanavalin A — Calvaria — Histomorphometry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Natural products such as plant lectins have not been extensively surveyed for their potential as anabolic agents. Wlodarski (1991) observed that the lectin Concanavalin A (ConA) has chondrogenic and osteogenic activity following local injection over the mouse tibia. To gain more insight into the mechanism of ConA in bone, we investigated and quantitated the effects of ConA injected locally over the mouse calvaria in vivo. ConA was injected subcutaneously over the calvaria of mice at 2, 10, and 20 μg per injection, four times a day, for three consecutive days. By day fourteen, a layer of new woven bone 30 μm thick had been laid down on the periosteal surface, resulting in a 36% increase in calvarial thickness (as compared with 2% in vehicle-treated controls). ConA also increased periosteal width and osteoblast surface in a dose-dependent manner. Concurrent administration of indomethacin (30 μg) with ConA (20 μg), four times a day for 3 days, strongly inhibited new bone formation. With a single injection of ConA (80 μg) over the calvaria, osteoclastic bone resorption and proliferation of osteoblast precursors and periosteum increased at day four, but showed a decrease at later times (14 and 28 days after injection). Except at the earliest time, there was little evidence of osteoclastic bone resorption. New bone width increased linearly over 28 days. In summary, ConA induced new bone formation in a pattern comparable with that of aFGF and bFGF, potent stimulators of calvarial bone formation (Dunstan, 1993), and this osteogenic effect was caused by an indomethacin-sensitive pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900215
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Dynamical symmetries and temporal segmentation (1995)
    Springer
    Journal of nonlinear science 5 (1995), S. 359-372 
    Details
    ISSN: 1432-1467
    Keywords: segmentation ; subharmonics ; nonlinear oscillations ; neural dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary Segmentation of a mixed input into recognizable patterns is a task that is common to many perceptual functions. It can be realized in neural models through temporal segmentation: formation of staggered oscillations such that within each period every nonlinear oscillator peaks once and is dominant for a short while. We investigate such behavior in a symmetric dynamical system. The fully segmented mode is one type of limit cycle that this system can exhibit. We discuss its symmetry classification and its dynamical characterization. We observe that it can be sustained for only a small number of segments and relate this fact to a limitation on the appearance of narrow subharmonic oscillations in our system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212906
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Intraoperative electromyogram monitoring of the recurrent laryngeal nerve: experience with an intralaryngeal surface electrode (1999)
    Springer
    Langenbeck's archives of surgery 384 (1999), S. 392-395 
    Details
    ISSN: 1435-2451
    Keywords: Key words Lesion of the recurrent laryngeal nerve ; EMG monitoring ; Intralaryngeal electrode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Introduction: A clinical method to localize the recurrent laryngeal nerve intraoperatively in order to minimize the risk of accidental injury is presented. Methods and results: By means of an electrode, the nerve was stimulated by a pulsed contact current. The resulting muscle potential was detected using an electrode placed in the larynx. We applied this technique during the time period between 1 January 1997 and 31 December 1998. In 96 cases of primary thyroid resection, the recurrent nerve was identified 167 times. The patients were operated on for nodular thyroid (n=85), Grave’s disease (n=9) and malignant papillary goiter (n=2). Retrospectively, the rate of intraoperative nerve injury, equivalent to the rate of postoperative transient and permanent nerve palsy, was 1.04% in the 96 patients and 0.60% with respect to the 167 nerves at risk. The rate of failure of the method was 7.29%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050219
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...