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  • 1
    Electronic Resource
    Electronic Resource
    Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetic GK rats and its defective augmentation by glucose (1995)
    Springer
    Diabetologia 38 (1995), S. 772-778 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin release ; intracellular calcium ; exocytosis ; GK rat ; permeabilized islets.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In spontaneously diabetic GK rats, insulin secretion from pancreatic beta cells in response to glucose is selectively impaired, probably due to deficient intracellular metabolism of glucose and impaired closure of KATP channels during glucose stimulation. By using electrically permeabilized islets of GK rats, we explored the functional modulations in exocytotic steps distal to the rise in [Ca2 + ]i in the diabetic condition. At 30 nmol/l Ca2 + (basal conditions) insulin release was similar between GK and non-diabetic control Wistar rats. In response to 3.0 μmol/l Ca2 + (maximum stimulatory conditions), insulin release was significantly augmented in permeabilized GK islets (p 〈 0.01). Raising glucose concentrations from 2.8 to 16.7 mmol/l further augmented insulin release induced by 3.0 μmol/l Ca2 + from permeabilized control islets(p 〈 0.001), but had no effect on that from permeabilized GK islets. The stimulatory effect of glucose on insulin release from permeabilized control islets was partly inhibited by 2,4-dinitrophenol, an inhibitor of mitochondrial oxidative phosphorylation (p 〈 0.01). The hyperresponse to Ca2 + in GK islets may play a physiologically compensatory role on the putative functional impairment both in [Ca2 + ]i rise and energy state in response to glucose in diabetic β cells, and may explain the relative preservation of insulin release induced by non-glucose depolarizing stimuli, such as arginine, from pancreatic islets in non-insulin-dependent diabetes mellitus. [Diabetologia (1995) 38: 772–778]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050351
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  • 2
    Electronic Resource
    Electronic Resource
    Pioglitazone time-dependently reduces tumour necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats (1998)
    Springer
    Diabetologia 41 (1998), S. 257-264 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Pioglitazone ; muscle TNF-α ; sphingomyelinase ; insulin resistance ; Wistar fatty rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the relationship between tumour necrosis factor-α (TNF-α) level in muscle and metabolic abnormalities in obesity and diabetes mellitus, pioglitazone, a novel insulin-sensitizing agent, was administered to Wistar fatty rats and time-dependent changes in muscle TNF-α content and plasma indicators of diabetes and obesity were measured. Wistar fatty rats were hyperglycaemic, hyperlipidaemic and hyperinsulinaemic, and their plasma and muscle TNF-α levels were two or more times higher than those in normal lean rats at 16 weeks of age. When pioglitazone was administered to fatty rats at a dose of 3 mg · kg–1· day–1, the plasma triglyceride level and TNF-α levels in plasma and muscle decreased time-dependently, and reached the levels of lean rats within 4 days. Plasma glucose and insulin levels also decreased time-dependently with pioglitazone, but on day 4, these levels were still much higher than the levels in lean rats. Neutral sphingomyelinase (SMase) activity in muscle of fatty rats was two times higher than that in lean rats and was lowered to the level of that in lean rats by 4 days' pioglitazone administration. The plasma leptin level in fatty rats was 8 times higher than that in lean rats, but pioglitazone did not affect the level during the 4-day administration period. These results suggest that an increase in TNF-α production and subsequent activation of SMase in muscle leads to metabolic abnormalities in obesity and diabetes and that antidiabetic activity of pioglitazone is deeply associated with the suppression of TNF-α production. [Diabetologia (1998) 41: 257–264]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050901
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  • 3
    Electronic Resource
    Electronic Resource
    Lobar dysmorphism of the kidney: reevaluation of junctional parenchyma using helical CT (1999)
    Springer
    Abdominal imaging 24 (1999), S. 196-199 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Computed tomography (CT), helical—Kidney, CT—Kidney, abnormalities.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The term “junctional parenchyma” (JP) has been used to represent many renal anomalies including lobar dysmorphism; however, it has not been evaluated with modalities other than ultrasound (US). Methods: Twenty-two kidneys with lobar dysmorphism incidentally found on helical computed tomography (CT) were studied. In all cases, axial, multiplanar reformation, and three-dimensional images on corticomedullary phase scans were analyzed. Fifteen additional kidneys were prospectively examined with US, and we compared those sonograms with helical CT findings. Results: Comparison of the US and helical CT findings showed that the JP defect and the JP line corresponded anatomically to the upper aspect of the renal sinus and to the thick mural cortex originating from that point, extending inferiorly, respectively. The lesions of lobar dysmorphism were situated deep in the medulla, adjacent to the cortex; however, findings on helical CT did not indicate JP. Conclusions: Although JP may have been seen on US in this study, it did not show fusion remnants of subkidneys but a combination of the upper aspect of the renal sinus, the mural cortex, and the lesion of lobar dysmorphism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900476
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  • 4
    Electronic Resource
    Electronic Resource
    Hemorrhage in pituitary adenoma: correlation of MR imaging with operative findings (1998)
    Springer
    European radiology 8 (1998), S. 971-976 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Pituitary adenoma ; MR imaging ; Hemorrhage ; Cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to correlate MR imaging and operative findings of hemorrhage in pituitary macroadenomas. We retrospectively reviewed MR images of 113 surgically proven pituitary adenomas. All patients were examined on a 1.5-T MR system. The intensity of intratumoral cystic cavities was correlated with operative findings. In 15 patients with pituitary apoplexy, we determined relationship between interval of MR examination after apoplectic event and MR signal intensity. In 8 patients with repeated preoperative MR examination, we evaluated sequential changes of intratumoral hemorrhage. There were 54 cavities at surgery: 52 were hemorrhagic and 2 were nonhemorrhagic. Twenty-nine of 52 hemorrhagic cysts demonstrated high/low signal (H/L) fluid–fluid levels on T2-weighted image (T2WI). In 19 of them, two components could be separately seen at operation: the supernatant high-intensity area represented xanthochromic fluid, and the dependent low-intensity area represented liquefied hematoma. The H/L fluid–fluid level was observed predominantly in hematomas on MR images obtained after longer intervals. In patients with repeated MR examination, follow-up MR imaging revealed additional hemorrhage or new formation of fluid–fluid levels. It was surprising that 12 of 14 cysts preoperatively judged as nonhemorrhagic in fact contained hemorrhagic components. The preoperative MR images are well correlated to the operative findings in hemorrhagic pituitary macroadenomas. It proved that 52 of 54 cystic cavities had hemorrhagic component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050498
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  • 5
    Electronic Resource
    Electronic Resource
    Correlation of lesions in the hippocampal region noted on MR images with clinical features (1997)
    Springer
    European radiology 7 (1997), S. 281-286 
    Details
    ISSN: 1432-1084
    Keywords: Key words: MR imaging ; Hippocampus ; Epilepsy ; Amnesia ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of our work was to compare the MR imaging findings of obvious hippocampal and/or juxtahippocampal lesions with corresponding clinical features. Magnetic resonance images of 63 patients with obvious lesions in the hippocampal and/or juxtahippocampal regions were reviewed and their findings were correlated with patients' clinical characteristics. Based on the MR and clinical findings, the patients were divided into four groups: (a) 26 patients with space occupying lesions or suspected vascular malformation frequently causing symptomatic temporal epilepsy; (b) 14 with hippocampal infarcts, which when left-sided or bilateral caused amnesia; (c) 11 with encephalitis and 5 with old temporal contusion usually accompanied by both amnesia and epilepsy; and (d) 7 with temporal atrophy and progressive dementia of subacute onset. Magnetic resonance imaging allows precise localization and evaluation of the clinical correlates of hippocampal and juxtahippocampal lesions, which frequently caused symptomatic temporal epilepsy and/or amnesic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050151
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  • 6
    Electronic Resource
    Electronic Resource
    CT and MR imaging of craniopharyngioma (1997)
    Springer
    European radiology 7 (1997), S. 464-469 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Craniopharyngioma ; MR ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We reviewed imaging findings of CT and MR imaging in 20 cases of surgically confirmed craniopharyngioma in an attempt to determine their relation to patterns of tumor extent. The relationship between these patterns and the frequency of preoperative CT diagnosis and MR imaging diagnosis according to the surgical diagnosis were determined. The CT technique was superior to MR imaging in the detection of calcification. The MR imaging technique was superior to CT for determining tumor extent and provided valuable information about the relationships of the tumor to surrounding structures. Thus, CT and MR imaging have complementary roles in the diagnosis of craniopharyngiomas. In cases of possible craniopharyngioma, noncontrast sagittal T1-weighted images may enable the identification of the normal pituitary, possibly leading to the correct diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050184
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple sulphatase deficiency and haemophagocytic syndrome (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 553-554 
    Details
    ISSN: 1432-1076
    Keywords: Key words Multiple sulphatase deficiency ; Haemophagocytic syndrome ; Inherited metabolic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 3-year-old boy with multiple sulphatase deficiency, complicated by a haemophagocytic syndrome, recovered with conventional treatment. Haemophagocytic syndrome can be a complication of many disorders including metabolic diseases, frequently triggered by intracellular viral and bacterial infections or even by drug administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050876
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  • 8
    Electronic Resource
    Electronic Resource
    Mechanical Properties and Corrosion Resistance of PM High Nitrogen Stainless Steel Consolidated by Hot Extrusion (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 318-320 (Oct. 1999), p. 681-686 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.318-320.681.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Oxidation of H-terminated Si(100) surfaces studied by high-resolution electron energy loss spectroscopy (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 77 (1995), S. 5125-5129 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The adsorption of oxygen on H-terminated Si(100) surfaces has been investigated by high-resolution electron energy loss spectroscopy (HREELS). Adsorptions of atomic oxygen occur even at room temperature. Si-OH stretching and Si-O-Si (B1) vibrational modes are observed in HREELS spectra, which indicates that atomic oxygen is adsorbed on sites of Si—H bonds and Si—Si back bonds. On the other hand, H-terminated surfaces are very stable for molecular oxygen, which cannot adsorb until 380 °C on the surface. A dissociative adsorption of molecular oxygen is observed above 380 °C and the activation energy of the adsorption is 2.0 eV at 380–450 °C. This value coincides with the desorption energy of hydrogen atoms from a Si(100) surface with the monohydride phase. These results indicate that the dangling bonds are essential to the adsorption of molecular oxygen on Si(100) surfaces. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.359323
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  • 10
    Electronic Resource
    Electronic Resource
    Patterns of care study of radiation therapy for esophageal cancer in Japan: influence of age on parameters of treatment (1998)
    Springer
    International journal of clinical oncology 3 (1998), S. 379-385 
    Details
    ISSN: 1437-7772
    Keywords: Patterns of Care ; Study ; Esophageal cancer Radiation therapy ; The elderly ; Parameter survey ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. In Japan, the elderly population is growing rapidly, and therefore, so is the number of cancer patients who are not good candidates for aggressive surgery or chemotherapy. Radiation therapy offers excellent potential for the treatment of such patients, with minimal invasion and functional preservation. A Patterns of Care Study (PCS) examined the parameters of treatments used for patients with esophageal cancer to determine nationwide variations by age. Methods. From July 1996 through February 1997, external nationwide PCS audits were performed for 29 institutions. Medical charts were reviewed for 455 patients with thoracic esophageal cancer treated between 1992 and 1994. The parameters of treatments used for these patients were compared between those aged ≥75 years (elderly; n = 113) and those aged 〈75 years (yourger; n = 342). Results. Surgery was used in 49% of the younger group and in 17% of the elderly group (P 〈 0.0001) while chemotherapy was used in 48% of the younger and 24% of the older group (P 〈 0.0001). The ratio of non-surgery group with radiation therapy increased significantly from 49% to 82% (P 〈 0.0001). Approximately 70% of the non-surgery patients received an external radiation dose of more than 60Gy, even in the elderly (P = 0.3001). Preliminary results showed no significant difference in survival between the two age groups (P = 0.5559). Conclusions. The use of radiation therapy in elderly people with esophageal cancer has increased markedly. The PCS provided important information about variations in radiotherapy parameters in patients with esophageal cancer in relation to age. Such information should be useful for future prospective studies of the elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539217
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