ISSN:
1432-2072
Keywords:
Key words MPTP
;
MPP+
;
α1-Microglobulin
;
Ulinastatin
;
Mouse urine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P 〈 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050580
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