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  • 1
    Electronic Resource
    Electronic Resource
    Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo (1997)
    Springer
    Inflammation research 46 (1997), S. 180-184 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Rat mast cells — Degranulation — Adenosine A3 receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To investigate the effects of adenosine receptor agonists and antagonists on 5-HT release from rat isolated pleural mast cells and on plasma protein extravasation in the skin of conscious rats.¶In vitro Methods: Rat isolated pleural mast cells were loaded with [14C] 5-HT, sensitised with mouse monoclonal anti-DNP and then challenged with human serum albumin-DNP. DNP-stimulated 5-HT release from mast cells was determined.¶In vivo Methods: Rats, loaded intravenously with [125I] human serum albumin, were injected intradermally with adenosine agonists at sites on the back. 30 min later plasma protein extravasation at each injection site was determined.¶Results: In isolated mast cells, each adenosine agonist enhanced DNP-induced 5-HT release, N6-(3-iodobenzyl)-5-(N-methyl-carboxamidoadenosine), (IB-MECA), being the most potent agonist. The adenosine A1/A2 antagonist, 8-phenyltheophylline (8-PT), had no effect on the response to IB-MECA. In contrast, 3-(4-amino-iodobenzyl)-8-[4-[[[carboxy]methyl]oxy]phenyl]-1-propylxanthine, (I-ABOPX), inhibited (pA2 6.2) the IB-MECA responses. In the skin of conscious rats, intradermal IB-MECA produced a marked plasma protein extravasation (PPE) which was mimicked by N6-2-(4-aminophenyl)-ethyladenosine (APNEA). The PPE produced by IB-MECA was not affected by either 8-PT or CGS15943A, but was virtually abolished by cyproheptadine and in rats pre-treated with Compound 48/80.¶Conclusions: These results indicate that stimulation of adenosine A3 receptors both enhances degranulation in vitro and directly produces degranulation of rat mast cells in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050169
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  • 2
    Electronic Resource
    Electronic Resource
    Computed tomographic evaluation and guided correction of malpositioned nephrostomy catheters (1999)
    Springer
    Abdominal imaging 24 (1999), S. 422-425 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Nephrostomy catheters—Computed tomography—CT guided—Dislodged nephrostomy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To determine the utility of computed tomography (CT) in the detection and correction of malpositioned nephrostomy catheters after contrast spillage during nephrostograms. Methods: CT was performed in nine patients after an abnormal (contrast spillage) tube nephrostogram performed during or after nephrostomy tube placement. CT was used to locate the nephrostomy catheter position in relation to the renal collecting system. If possible, CT was also used for guidance and repositioning of the nephrostomy catheters into the intrarenal collecting system. Results: In all nine cases, CT was successful in detecting the position of the suspected malpositioned catheter. In seven of nine cases, CT demonstrated the catheter outside the renal collecting system and effectively helped reposition the catheters into the intrarenal collecting system. In one case, the malpositioned nephrostomy catheter was within the intraperitoneal cavity and required surgical correction. Another case required fluoroscopic-guided repositioning for the initial nephrostomy catheter, which was partly posterior to the kidney and partly within the kidney. The catheter in this latter case was successfully advanced over a guidewire into the collecting system. Conclusions: CT may be used to detect possible catheter malposition associated with nephrostomy tube placement. CT may also be used to successfully guide catheter repositioning in the renal collecting system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900529
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  • 3
    Electronic Resource
    Electronic Resource
    A case of Capgras delusion following critical illness (1999)
    Springer
    Intensive care medicine 25 (1999), S. 1183-1184 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Hallucinations and paranoid delusions are recognised complications of critical illness. However, the occurrence of Capgras syndrome, in response to critical illness, where patients are convinced that doubles have replaced close family has not been described in the literature. There have been isolated case histories in the literature in response to medical procedures or illness but mostly in patients suffering from schizophrenia. A 42 year old woman was admitted to the intensive care unit (ICU) with pneumonia, following extensive surgery for a squamous cell carcinoma, secondary to Crohns disease. She had no history of previous head injury, cerebro-vascular problems or psychiatric disorder. She reported having memories of all her family, with the exception of her mother, being replaced by aliens while she was on the ICU. The delusion was only diagnosed once it had resolved and the patient was able to talk, and this highlights the difficulty of diagnosing delusions while patients are still intubated and unable to verbalise their concerns. It has been suggested that a defect in the ability to recognise the emotional significance of the face lies at the root of Capgras syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051035
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  • 4
    Electronic Resource
    Electronic Resource
    The use of the laryngeal mask airway for inter-hospital transport of infants with type 3 laryngotracheo-oesophageal clefts (1999)
    Springer
    Intensive care medicine 25 (1999), S. 714-716 
    Details
    ISSN: 1432-1238
    Keywords: Key words Layngeal mask airway ; Laryngotracheo-oesophageal cleft ; Inter-hospital transfers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Type 3 laryngotracheo-oesophageal clefts are rare congenital anomalies with a high mortality. In the past, transport of such infants to tertiary centres for surgical correction has proved extremely difficult, with the child's ventilatory status often deteriorating to such an extent that ultimate surgical intervention has not proved possible. We describe two cases of successful inter-hospital transfer of infants with type 3 laryngotracheo-oesophageal clefts using the laryngeal mask airway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050934
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  • 5
    Electronic Resource
    Electronic Resource
    Poly-3-hydroxybutyrate production by washed cells of Alcaligenes eutrophus; purification, characterisation and potential regulatory role of citrate synthase (1997)
    Springer
    Archives of microbiology 168 (1997), S. 486-492 
    Details
    ISSN: 1432-072X
    Keywords: Key words Poly-3-hydroxybutyrate ; Washed cells ; Alcaligenes eutrophus ; Citrate synthase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Washed cells prepared from carbon-limited continuous cultures of Alcaligenes eutrophus synthesised poly-3-hydroxybutyrate (PHB) rapidly when supplied with glucose, dl-lactate or l-lactate. Unlike growing cultures, washed cells excreted significant amounts of pyruvate. The combined rates of PHB production (qPHB) and pyruvate excretion (qPyr) were linearly related to the rate of carbon substrate utilisation (qS), showing that washed cells behaved similarly to growing cultures when corrected for the absence of non-PHB biomass production. The addition of formate (as a potential source of NADH and/or ATP) significantly stimulated both qPHB and qPyr, but slightly decreased qS and substantially decreased the flux of carbon through the tricarboxylic acid cycle (qTCA). Citrate synthase activity of broken cells was inhibited by physiological concentrations of NADH, but not of ATP, in a manner that was not reversible by AMP. Citrate synthase was purified and shown to be a “large” form of the enzyme (M r 227,000), comprising a single type of subunit (M r 47,000) as found in several other gram-negative aerobes. The potential role of citrate synthase in the regulation of PHB production via its ability to control carbon flux into the tricarboxylic acid cycle is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050526
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  • 6
    Electronic Resource
    Electronic Resource
    Bone mineralisation in ex-preterm infants aged 8 years (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 658-661 
    Details
    ISSN: 1432-1076
    Keywords: Key words Infant-premature ; Bone mineralisation ; Dual energy X-ray absorptiometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In preterm infants, in whom perinatal mineralisation deficits are common, there is little information on long-term bone mineralisation. Using a Hologic QDR 1000 dual energy X-ray absorptiometer, bone mineral content and density (BMC and BMD) were measured in lumbar, spine, forearm and hip in 46 ex- preterm infants 〈32 weeks gestation together with controls at 8 years of age. Height and weight were recorded, as was history of bone fracture. Preterm infants were shorter by 4.9 cm (95% CI, 2.4 – 7.3) and lighter by 2.6 kg (95% CI, 0.7 – 4.4). BMC for all sites measured was significantly lower in the preterm group, but did not remain so when adjusted for height and weight. BMD was significantly reduced in the hip of the preterm group. Prolonged ventilation was associated with the lowest BMC and duration of preterm formula feeding correlated with higher BMC. Accidental fractures were less common in the preterm group. Conclusion Ex preterm infants have significant reduction in bone mineral mass commensurate with their reduced growth and reduced bone mineral density in their hips.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051171
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  • 7
    Electronic Resource
    Electronic Resource
    Recent Advances in the Syntheses and Structures of some Lanthanoid Group 15 Hetrocyclic Complexes (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 315-317 (July 1999), p. 136-143 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.315-317.136.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    The weak cervix: failing to keep the baby in or infection out? (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb09979.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hierarchies, networks and management accounting in NHS hospitals (1999)
    Bradford : Emerald
    Accounting, auditing & accountability journal 12 (1999), S. 164-188 
    Details
    ISSN: 0951-3574
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The pursuit of cost efficiency in the British National Health Service has resulted in increased emphasis on devolved financial accountability and the introduction of an internal market. With the aid of a case study, this paper examines alternative forms of governance and proposes that aspects of the internal market and functioning within acute hospital units, are suited to network-style organisation. The implications of hierarchies and networks for the design and use of management accounting information (MAI) are identified. These are used to analyse the case evidence concerning the roles, intended and unintended, of MAI in the context of organisational change and where multiple, and sometimes conflicting, goals and priorities existed. It concludes that a network approach to the design of MAI is more consistent with the desirable culture, at operational level, in acute units. However, this will only be achieved through deliberate intervention by those who design MAI systems and senior managers, who by their attitudes towards the interpretation and response to MAI, shape overall organisational culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09513579910270093
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization, crystallization and preliminary X-ray investigation of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus (1998)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 671-674 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Recombinant Sulfolobus solfataricus glyceraldehyde-3-phosphate dehydrogenase has been purified and found to be a tetramer of 148 kDa. The enzyme shows dual cofactor specificity and uses NADP+ in preference to NAD+. The sequence has been compared with other GAPDH proteins including those from other archaeal sources. The purified protein has been crystallized from ammonium sulfate to produce crystals that diffract to 2.4 Å with a space group of P43212 or P41212. A native data set has been collected to 2.4 Å using synchrotron radiation and cryocooling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444997018076
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