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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 6 (1996), S. 0 
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Conventional treatments have not slowed down the ever expanding low back pain (LBP) problem. Traditional treatment has most probably contributed to the growth of the problem. Therefore, in a search for new solutions, ‘functional restoration’ has been devised. In connection with chronic LBP the term has been associated with a full-day program lasting from 3 to 5 weeks. it includes multidisciplinary treatment of patients in groups with intensive physical and ergonomic training, psychological pain management, back school, as well as teaching in social/work related issues. The key concepts are ‘acceptance of the pain’, ‘activity’, ‘self-responsibility’, ‘multidisciplinary’ and ‘quantitative functional evaluation (QFE)’. The latter is aimed so that the participants can feel the physical improvement, encouraging them to be able to go back to work, or at least to lead a more active life style. Several controlled studies suggest a lasting effect in terms of regaining their ability to work and improving pain behavior for a good part of disabled chronic LBP patients. However, it is noteworthy that randomized studies seemingly show poorer results than studies not employing randomized controls.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 67 (1998), S. 71-98 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes use protein free radicals to activate the substrate. Aerobic class I enzymes generate a tyrosyl radical with an iron-oxygen center and dioxygen, class II enzymes employ adenosylcobalamin, and the anaerobic class III enzymes generate a glycyl radical from S-adenosylmethionine and an iron-sulfur cluster. The X-ray structure of the class I Escherichia coli enzyme, including forms that bind substrate and allosteric effectors, confirms previous models of catalytic and allosteric mechanisms. This structure suggests considerable mobility of the protein during catalysis and, together with experiments involving site-directed mutants, suggests a mechanism for radical transfer from one subunit to the other. Despite large differences between the classes, common catalytic and allosteric mechanisms, as well as retention of critical residues in the protein sequence, suggest a similar tertiary structure and a common origin during evolution. One puzzling aspect is that some organisms contain the genes for several different reductases.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Gerontologie + Geriatrie 32 (1999), S. S69 
    ISSN: 0044-281X
    Keywords: Key words malnutrition – enteral nutritional support – percutaneous endoscopic gastrostomy (PEG) – formula diets – home enteral nutrition ; Schlüsselwörter Mangelernährung – enterale Ernährungstherapie – perkutane endoskopische Gastrostomie (PEG) – Formeldiäten – heimenterale Ernährung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mangelernährung ist ein häufiges Problem bei geriatrischen Patienten. Die Inzidenz der Malnutrition wird mit 30–65 % angegeben. Bei vielen Patienten besteht deshalb die Indikation zu einer intensivierten Ernährungstherapie. Unter den verfügbaren Kathetersystemen ist die perkutane endoskopische Gastronstomie (PEG) meist Methode der Wahl. Sie bietet gegenüber nasogastralen Sonden einige bedeutende Vorteile, wie ein verringertes Risiko der Sondendislokation und -okklusion und eine erhöhte Akzeptanz durch die Patienten. Bei Beachtung der Richtlinien zur Katheterpflege und Sondenkostapplikation sind Komplikationen der enteralen Ernährung selten. Frühzeitig sollte an eine heimenterale Versorgung der Patienten gedacht werden, um dem Patienten die Rückkehr in die vertraute heimische Umgebung zu ermöglichen.
    Notes: Summary Malnutrition is known to be very common in geriatric patients. The incidence is ranging from 30 to 60 % of all patients. Therefore, indication for nutritional support via nasogastric or percutaneous tubes is frequently given. Since percutaneous endoscopic gastrostomy (PEG) has several advantages over nasogastric tube feeding including reduced risk of tube displacement and blockage, and higher patient acceptance, it has become the method of choice in enteral tube feeding. Complication rates are low provided that guidelines for enteral tube feeding are considered. Early home enteral nutrition contributes to patients quality of life.
    Type of Medium: Electronic Resource
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