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  • 1
    Electronic Resource
    Electronic Resource
    Postpolio syndrome: poliovirus persistence is involved in the pathogenesis (1999)
    Springer
    Journal of neurology 246 (1999), S. 472-476 
    Details
    ISSN: 1432-1459
    Keywords: Key words Postpolio syndrome ; Reverse transcriptase ; polymerase ; chain reaction ; Poliovirus ; persistence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathogenesis of the postpolio syndrome (PPS) remains unclear. In this study we looked for poliovirus (PV) persistence in the CSF of 20 patients with PPS, in a control group including 20 patients with unrelated neurological diseases, and in 7 patients with stable poliomyelitis sequelae. CSF samples and sera were examined using reverse transcriptase–polymerase chain reaction (RT-PCR) for the detection of PV or other enterovirus genomes; this assay allows the detection from as little as 1 fg viral RNA. Sequencing of amplified products from 5 patients was performed. PV genomic sequences were detected in the CSF of 11 of 20 patients with PPS and in none of the control group. Sequencing in the 5′ untranslated region confirmed the presence of mutated PV sequences. These findings suggest that PPS is related to the persistence of PV in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050386
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  • 2
    Electronic Resource
    Electronic Resource
    Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein (1997)
    [s.l.] : Nature Publishing Group
    Nature 387 (1997), S. 500-505 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Transgenic mice were produced by using a construct containing an APP complementary DNA fragment encoding amino acids 591 to 695, which spans the amyloid-forming portion and the carboxy terminus of the human amyloid precursor protein, cloned into the first exon of the human neurofilament NF-L gene ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/387500a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ectopic Substance P and Calcitonin Gene-related Peptide Immunoreactive Fibres in the Spinal Cord of Transgenic Mice Over-expressing Nerve Growth Factor (1995)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 7 (1995), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to investigate the in vivo effects of CNS over-expression of nerve growth factor (NGF) on primary sensory neurons. To achieve this objective a transgenic mouse model was generated which bore a chick NGF gene driven by the myelin basic protein promoter. Northern blot analysis demonstrated that high levels of NGF mRNA were detected in the spinal cord of adult transgenic mice. Using immunocytochemistry NGF-immunoreactive (IR) oligodendrocytes were observed throughout the white matter. Furthermore, numerous ectopic substance P (SP)- and calcitonin gene-related peptide (CGRP)-IR fibres were detected in the white matter of the spinal cord of transgenic mice. NGF-IR oligodendrocytes and ectopic SP- and CGRP- fibres were entirely absent from control mice. In the cervical and lumbar dorsal root ganglia, the percentages of SP-IR neurons were significantly higher in transgenic mice when compared with controls. At the electron microscope level, ectopic SP- and CGRP-IR fibres were characterized as unmyelinated axons and axonal boutons. SP co-localized with CGRP in some of those axonal boutons and fibres. Capsaicin treatment of adult mice completely abolished the ectopic SP-IR fibres, confirming their primary sensory origin. Our results indicate that primary sensory neurons are responsive to NGF over-expression in the CNS. Ectopic SP- and CGRP-IR fibres in the white matter are likely to represent collateral sprouts of the central processes of the dorsal root ganglion cells which were triggered by NGF over-expressed in the myelinating oligodendrocytes in the spinal cord of transgenic mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1995.tb00625.x
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  • 4
    Electronic Resource
    Electronic Resource
    Search for Poliovirus in Specimens from Patients with the Post-Polio Syndrome (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 753 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb27549.x
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  • 5
    Electronic Resource
    Electronic Resource
    Association of apolipoprotein ɛ4 allele and neuropathologic findings in patients with dementia (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 239-243 
    Details
    ISSN: 1432-0533
    Keywords: Apolipoprotein E ; Dementia ; Diffuse Lewy body disease ; Alzheimer's disease ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apolipoprotein E (APOE) is a lipoprotein expressed in liver and brain as one of three isoforms (APOE 2, APOE 3 and APOE 4). Recent findings suggest that the presence of APOE 4 is associated with an increased risk for both familial Alzheimer's disease and late-onset Alzheimer's disease. We extended these observations by determining the frequency of APOE alleles in patients with pathologically confirmed Alzheimer's Disease (AD), Parkinson's disease (PD), diffuse Lewy Body disease (DLBD), AD with concomitant PD pathology, demented PD patients without or with concomitant AD pathology and in schizophrenics with a progressive dementia (SCHIZ+DEM). The APOE genotype was determined by restriction digestion of polymerase chain reaction-amplified DNA isolated from frozen brain samples. The frequency of the APOE ɛ4 allele was highest among sporadic AD and DLBD patients (0.30 and 0.38, respectively) and lowest in the SCHIZ+DEM and non-demented PD patients (0.06 and 0.1, respectively). Thus, the APOE ɛ4 allele is over-represented selectively in patients with dementias associated with plaques and tangles and/or cortical Lewy bodies, but not in demented schizophrenics or non-demented PD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296506
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Association of apolipoprotein ε4 allele and neuropathologic findings in patients with dementia (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 239-243 
    Details
    ISSN: 1432-0533
    Keywords: Key words Apolipoprotein E ; Dementia ; Diffuse Lewy body disease ; Alzheimer's disease ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apolipoprotein E (APOE) is a lipoprotein expressed in liver and brain as one of three isoforms (APOE 2, APOE 3 and APOE 4). Recent findings suggest that the presence of APOE 4 is associated with an increased risk for both familial Alzheimer's disease and late-onset Alzheimer's disease. We extended these observations by determining the frequency of APOE alleles in patients with pathologically confirmed Alzheimer's Disease (AD), Parkinson's disease (PD), diffuse Lewy Body disease (DLBD), AD with concomitant PD pathology, demented PD patients without or with concomitant AD pathology and in schizophrenics with a progressive dementia (SCHIZ+DEM). The APOE genotype was determined by restriction digestion of polymerase chain reaction-amplified DNA isolated from frozen brain samples. The frequency of the APOE ε4 allele was highest among sporadic AD and DLBD patients (0.30 and 0.38, respectively) and lowest in the SCHIZ+DEM and non-demented PD patients (0.06 and 0.1, respectively). Thus, the APOE ε4 allele is over-represented selectively in patients with dementias associated with plaques and tangles and/or cortical Lewy bodies, but not in demented schizophrenics or non-demented PD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296506
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    Paper (German National Licenses)
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