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  • 1
    Electronic Resource
    Electronic Resource
    Angiosarcoma of the scalp associated with renal transplantation (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of cutaneous angiosarcoma occurring in a 51-year-old male renal transplant patient is reported. Multiple violaceous nodules surrounded by poorly demarcated red to purple discoloration were found on his scalp. Immunosuppressants consisting of azathioprine and prednisolone had been administered during the 12-year period since the renal transplantation. We diagnosed the lesion clinically as a cutaneous angiosarcoma and performed a wide surgical excision. The histopathological findings confirmed the diagnosis and showed tumour cells in the peripheral margin. Postoperatively, the patient started immunotherapy with systemic administration of recombinant interleukin-2 (rIL-2), but he refused to continue it because of the acute rejection of the transplanted kidney induced by the rIL-2. Instead he received radiation therapy (total 7000 rad) of the scalp. Although no recurrence was noticed for 15 months after the completion of radiation, he died due to lung metastasis from angiosarcoma. We review the seven cases, including ours, of angiosarcoma after renal transplantation that are reported in detail in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.6691611.x
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  • 2
    Electronic Resource
    Electronic Resource
    The activity of lecithin: Cholesterol acyltransferase in the serum of cows at parturition or with fatty liver (1995)
    Springer
    Veterinary research communications 19 (1995), S. 343-351 
    Details
    ISSN: 1573-7446
    Keywords: cow ; fatty liver ; fertility ; lecithin ; cholesterol acyltransferase ; lipoprotein ; parturition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity of lecithin: cholesterol acyltransferase (LCAT), which is responsible for esterification of plasma cholesterol, was evaluated in bovine serum. It was associated with the high-density lipoprotein fraction that contains apolipoprotein A–I, an activator of LCAT. In lactating cows, the activity was around 1000 U (decrease in nmol of free cholesterol per h per ml of serum), slightly higher than in 1-month-old calves. LCAT activity decreased around parturition, at which the time the serum concentrations of cholesteryl esters and free cholesterol were concomitantly decreased. A reduced LCAT activity was also found in cows with fatty livers induced by the administration of ethionine. In the cows with fatty livers, the serum concentration of cholesteryl esters was markedly decreased, whereas that of free cholesterol was only slightly decreased, thereby increasing the free- to esterified-cholesterol ratio. These results suggest that the decrease in LCAT activity may be involved in the reduction in fertility associated with fatty liver because esterification of cholesterol by LCAT is essential for its transport from the liver to peripheral tissues, such as the corpus luteum, and because cholesterol serves as the source of progesterone synthesis in the latter organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01839316
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased Serum Lecithin:Cholesterol Acyltransferase Activity in Spontaneous Cases of Fatty Liver in Cows (1997)
    Springer
    Veterinary research communications 21 (1997), S. 1-8 
    Details
    ISSN: 1573-7446
    Keywords: cattle ; cholesteryl esters ; fatty liver ; lecithin:cholesterol acyltransferase ; lipoprotein ; phosphatidylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nakagawa, H., Oikawa, S., Oohashi, T. and Katoh, N., 1997. Decreased serum lecithin:cholesterol acyltransferase activity in spontaneous cases of fatty liver in cows. Veterinary Research Communications, 21 (1), 1-8. Lecithin:cholesterol acyltransferase (LCAT) activity in serum was evaluated in spontaneous cases of fatty liver in cows. The enzyme activity of 631 ± 62 U (mean ± SEM, decrease in nmol of free cholesterol per h per ml of serum) in cows with fatty liver (n = 16) was significantly (p 〈 0.01) lower than that in cows without fatty liver (979 ± 22 U; n = 16). In addition to the decrease in LCAT activity, the concentrations of phosphatidylcholine (a fatty aryl donor for esterification of free cholesterol) and of cholesteryl esters (products of the LCAT reaction) were reduced in the high-density lipoprotein fractions from cows with fatty livers. The concentration in the serum of apolipoprotein A-I, an activator of LCAT, was also reduced in cows with fatty livers. These results suggest that the decreased LCAT activity, which may be attributable to impaired hepatic secretion or to the suppression of the activity in the plasma by reduced concentrations of phosphatidylcholine and apolipoprotein A-I, resulted in the lower concentrations of cholesteryl esters. Because cholesteryl esters are utilized in steroidogenic tissues for the synthesis of steroid hormones such as progesterone and glucocorticoids, an insufficient supply of the cholesterols may be of relevance to the reduced fertility and immune competence observed in cows with fatty livers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:VERC.0000009695.02015.20
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  • 4
    Electronic Resource
    Electronic Resource
    Reduced Activity of Lecithin:Cholesterol Acyltransferase in the Serum of Cows with Ketosis and Left Displacement of the Abomasum (1998)
    Springer
    Veterinary research communications 22 (1998), S. 517-524 
    Details
    ISSN: 1573-7446
    Keywords: abomasal displacement ; acyltransferase ; cattle ; cholesterol ; cholesteryl esters ; enzyme ; ketosis ; lecithin ; phospholipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lecithin:cholesterol acyltransferase (LCAT) activity was evaluated in sera from cows with ketosis and in some with left displacement of the abomasum (LDA) that occurred during early lactation. The enzyme activities of 652±214 U (mean±SD) in cows with ketosis (n = 6) and 683±110 U in those with LDA (n = 5) were significantly (p〈0.01) decreased compared to those in healthy normal cows (994±65 U, n = 8). Serum concentrations of free cholesterol, cholesteryl esters (CE) and phospholipids were similarly decreased in the two diseases. Cows whose LCAT activity and CE concentration were lower than the normal values were detected while in the non-lactating stage, and some of these cows had ketosis after parturition. It is suggested that evaluation of the LCAT activity and of the CE concentration during the non-lactating stage would be useful in detecting cows that are susceptible to postparturient disorders such as ketosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006189603071
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    Paper (German National Licenses)
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