Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis of the first Japanese patient with 3-oxo-δ 4-steroid 5β-reductase deficiency by use of immunoblot analysis (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 386-390 
    Details
    ISSN: 1432-1076
    Keywords: Key words 3-Oxo-Δ4-steroid 5β-reductase deficiency ; 3-oxo-Δ4 bile acid ; Immunoblot analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 3-oxo-Δ4-steroid 5β-reductase (5β-reductase) deficiency is difficult to diagnose because severe liver damage can result in a similar pattern of metabolite excretion. We investigated the usefulness of immunoblot analysis for diagnosis of 5β-reductase deficiency and quantitatively analysed urinary bile acids by gas chromatography-mass spectrometry in a 5-month-old Japanese boy with severe neonatal cholestasis associated with hypertyrosinaemia. A liver sample was examined by immunoblot analysis using monoclonal antibodies against 5β-reductase. Urinary 3-oxo-Δ4 bile acids accounted for 88.3% of total bile acids, 5α-bile acids for 0.9%, and primary bile acids for 9.1%. Immunoblot analysis of the liver tissue showed an indistinct band of 5β-reductase. Conclusions These findings suggest that this patient had a secondary 5β-reductase deficiency due to severe liver damage, even though 3-oxo-Δ4 bile acids constituted more than 70% of total urinary bile acids. However, the patient may possibly have had an inherited 5β-reductase deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050835
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Bronchial hyperresponsiveness and airway neutrophil accumulation induced by interleukin-8 and the effect of the thromboxane A2 antagonist S-1452 in guinea-pigs (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-8 (IL-8) has been shown to be a chemotactic factor for neutrophils, T-lymphocytes and eosinophils, but it is unknown whether the IL-8-induced inflammatory cell accumulation into the airways can cause the bronchial hyperresponsiveness (BHR) characteristic of asthma. IL-8 at a dose of 0.5 or 5μg/kg was administered intranasally to guinea-pigs twice a week for 3 weeks. One day after the last administration, animals were anesthetized and artificially ventilated through tracheal cannula and lateral pressure at the cannula (Pao) was measured as an overall index of airway responses to increasing concentrations of inhaled histamine (25, 50, 100, and 200 μg/ml). The IL-8 treatment significantly enhanced bronchial responsiveness to histamine in a dose-dependent manner (ANOVA P 〈 0.01). The provocative concentration of histamine causing a 100% increase in Pao (PC100) at a dose of 0.5 and 5μg/kg of IL-8 was 68.1 (Gsem 1.12) and 35.6 (Gsem 1.25) μg/ml, respectively. The latter was significantly (P 〈 0.01) lower than that in control animals treated with PBS (93.3 [Gsem, 1.14] μg/ml)- The IL-8 treatment also induced a significant influx of neutrophils, but not eosinophils, in bronchoalveolar lavage (BAL) fluid (18.3 ± 8.8 and 30.6 ± 8.3% in animals treated with 0.5 and 5 μg/kg, respectively, of IL-8 vs 3.6 ± 0.7% in phosphate buffered saline-(PBS)-treated animals). Furthermore, we examined the effect of the thromboxane receptor antagonist S-1452 (0.01 or 0.1 mg/kg, i.p. 24 and 1 h before anesthesia) on this IL-8 induced BHR. S-1452 significantly inhibited the BHR dose-dependently (ANOVA P 〈 0.001). PC100 was 94.0 (Gsem 1.19), 137.4 (Gsem 1.17) and 43.0 (Gsem 1.24) μg/ml with S-1452 at doses of 0.01 and 0.1mg/ml and saline, respectively. We conclude that IL-8 causes BHR and airway neutrophil inflammation, and that thromboxane A2 is important in the development of BHR induced by IL-8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb01002.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Spectral narrowing of an optically pumped high-power D2O laser using the oscillator-amplifier system (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 77 (1995), S. 1378-1384 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Spectrally narrow outputs of about 10 MHz (full width at half-maximum) are obtained from an optically pumped high-power (100 kW) D2O laser system by using the oscillator-amplifier configuration, in which a low-power single-mode output from a compact D2O laser with a short cavity length is amplified by a large D2O laser amplifier. In order to obtain spectrally narrow outputs from the amplifier, the following three conditions need to be satisfied: (1) the D2O gas pressure of the amplifier is adjusted in the range from 4 to 6 Torr; (2) the oscillation frequency of the compact laser is tuned in the range about 15–35 MHz lower than the Raman resonance frequency; and (3) the intensity of the compact laser beam injected into the amplifier is larger than about 50 W/cm2. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.358949
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Complete integral suppression of Pfirsch–Schlüter current in a stellarator plasma in Heliotron E (1998)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 5 (1998), S. 481-485 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The poloidal magnetic field was measured to detect the plasma boundary position. It was found that the pressure-induced plasma shift, an observable characteristic of the Pfirsch–Schlüter current, depends strongly on the initial position of the magnetic axis. When the axis was moved by the vertical field inside the torus, the finite-β shift became smaller. Complete suppression of the finite-β plasma shift was achieved in a deeply inward shifted configuration: 7 cm from the standard position Raxis=2.20 m. This effect is explained by magnetohydrodynamic (MHD) equilibrium theory for stellarator toroidal plasmas with a large magnetic hill and deep inward shift. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.873140
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Hysteresis variations of (Pb, La)(Zr, Ti)O3 capacitors baked in a hydrogen atmosphere (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 74 (1999), S. 3395-3397 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Baking (Pb, La)(Zr, Ti)O3 capacitors in a hydrogen atmosphere causes a significant loss of remanent polarization even at 150 °C. The hysteresis variations depend on the polarization states during baking. The hysteresis loop showed voltage shifts when the capacitor was polarized before baking, whereas it became a cramped shape when the baking was carried out on a virgin capacitor. Although remanent polarization diminished in all cases, saturation polarization was not suppressed. The clamped hysteresis loop can be described as an average of two loops shifted to positive and negative voltages. The results indicate that the loss of remanent polarization is not due to the suppression of switching, but due to the shift of the hysteresis of each domain larger than the coercive voltage. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.123356
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Densified silica glass after shock compression (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 81 (1997), S. 1651-1655 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Silica glasses were repeatedly densified by multiple shock reverberations in stainless-steel capsules. The limit of increase in density was about 2.47 Mg/m3 after the first shock loading. Further increase in density was observed after duplicate shock loading, but limited at about 2.55 Mg/m3. Triplicate shock loading was not so effective for the increase in density. The Raman spectra of recovered silica glasses had characteristics of densified silica glass with much higher density. The remarkable one was the enhancement of the line at 605 cm−1 called the D2 line, which was one of two narrow lines peculiar to the Raman spectrum of silica glass. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.364021
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Transparent nanocrystalline diamond ceramics fabricated from C60 fullerene by shock compression (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 3016-3018 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Transparent nanocrystalline diamond ceramics, consisting of a few nanometer-sized diamond crystallites that are unstable in themselves because of higher surface energy, were fabricated successfully from C60 fullerene using a shock compression and rapid quenching technique. The platelets were transparent and very hard, nearly comparable to type IIa diamond. Transmission electron microscopy and electron energy loss spectroscopy revealed that individual crystallites had combined directly or through a very thin and modified sp3 carbon layer, which possibly stabilized the nanometer-sized crystallites. The size order and sp3 configuration of the nanotexture caused the transparency and hardness of the present material. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.120248
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Gain analysis for surface emission by optical pumping of wurtzite GaN (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 94-96 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We analyzed optically pumped surface emissions by calculating the optical gain in bulk GaN. We found that GaN has a large gain of over 104 cm−1 and no gain saturation up to 25 000 cm−1 . This high optical gain is generated by the high joint-density of states due to the three valence bands close to band edge and the large effective mass of the conduction band. As a result, although the gain required for lasing in the vertical direction is very high, the high excitation of carriers can achieve this without an intentional high reflection structure. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.118131
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Capabilities of polymer-modified monodisperse colloidal silica particles as biomaterial carrier (1997)
    Springer
    Colloid & polymer science 275 (1997), S. 220-226 
    Details
    ISSN: 1435-1536
    Keywords: Key words Biomaterial carrier ; immunolatex ; protein immobilization ; monodisperse colloidal silica ; polymer modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Polymer modification of monodispersed colloidal silica (0.5 μm) with poly(maleic anhydride-co-styrene) (P(MA-ST)) and poly (maleic anhydride-co-methyl methacrylate) (P(MA-MMA)) and application of the composite particles to biomaterial carriers were investigated. The reaction of bovine serum albumin(BSA)-immobilized P(MA-MMA)/SiO2 with the anti-BSA antibody showed higher sensitivity in immunological agglutination test than BSA–P(MA-ST)/SiO2, though immobilization efficiency of BSA on P(MA-MMA)/SiO2 was lower than that on P(MA-ST)/SiO2. Alkaline phosphatase and glucose oxidase immobilized on the composite particles exhibited extremely low activities, but α-chymotrypsin immobilized on P(MA-MMA)/SiO2 and its derivative particles showed the relative activity of 12.5% and 16.1% to the native enzyme, respectively. Grafting of a hydrophilic polymer of poly(acrylic acid) to P(MA-ST)/SiO2 let to an increase of the immobilized α-chymotrypsin activity to give the maximum relative activity of 55.5%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050075
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Ionization via an ultrashort high-power KrF laser (1997)
    Springer
    Applied physics 65 (1997), S. 475-480 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 32.00
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400050299
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...