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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Arteries ; stenosis or obstruction ; Dialysis fistula obstruction ; Bypass obstruction ; Thrombectomy ; Hydrodynamic thrombectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A hydrodynamic thrombectomy catheter was prospectively evaluated for the treatment of recently thrombosed vessels. A total of 52 consecutive patients (42 males and 10 females; mean age 64 ± 15 years) presenting with acute or subacute occlusion of dialysis shunts (n = 25), peripheral bypass (n = 14) or native arteries (n = 15) were treated with the Hydrolyser (Cordis Europa NV, Roden, The Netherlands). Mean occlusion time was 4 days (range 1–17 days) and mean thrombus length 19 ± 11 cm. The Hydrolyser was effective and fast in removing thrombus, regardless of the thrombus length. No major complications were reported. The immediate procedure success rates were 82, 100, 87 and 79 % for Brescia Cimino, dialysis shunt, native arteries and bypass grafts, respectively. Adjunctive thrombolysis (applied for persistence of residual thrombus or thrombosed distal vessels too small for hydrolytic thrombectomy) was required in 4 % of thrombotic dialysis shunts, in 20 % of native arteries and in 50 % of bypass graft occlusions. On angiographic controls, distal embolizations were reported only in native arteries (13 %) and bypasses (14 %); all were successfully treated percutaneously, except for one case treated by Fogarty balloon. Cumulative primary patency rates were respectively at 6 months 56, 62, 78 and 65 % for each indication. We conclude from this preliminary clinical study that hydrodynamic thrombectomy with a Hydrolyser is a promising technique to treat acute occlusions. This device can reduce complications as well as the time required to remove large amounts of thrombus and the use of expensive thrombolytic drugs.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1084
    Keywords: Key words: Parathyroid adenoma ; Ethanol injection ; Hyperparathyroidism ; Interventional radiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to evaluate mid- and long-term results of ultrasonically guided ethanol injection into parathyroid adenomas. From 1988 to 1996, 27 patients (mean age 77 ± 13 years) were treated for parathyroid adenomas by percutaneous ethanol injection. The survey included clinical information, plasma calcium, phosphorus and PTH (1–84) evaluation. Follow-up lasted 22.6 ± 10 months. No major complications were observed for 63 ethanol injections. Biochemical recovery was 58 %, biochemical improvement at 3 months was 33 %, and failure was 7 %. Four of 15 cured patients presented a recurrence of the disease 1 or 2 years after the first treatment. Ultrasonically guided ethanol injection can be useful in the treatment of parathyroid adenomas when surgery is not possible. The immediate results are interesting but not as good as those obtained with surgery. A regular biochemical survey is necessary so that recurrences can be recognized and treated at an early stage.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 37-40 
    ISSN: 0340-1855
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 50-52 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Ochronose ; Alkaptonurie ; Chronische Polyarthritis ; Key words Ochronosis ; alkaptonuria ; rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Ochronosis is a rare disorder of tyrosin catabolism with an autosomal, recessive trait. Clinical signs predominantly affect the locomotor system. Inflammatory episodes in large joints can mimick Rheumatoid Arthritis (RA). Brownish discoloration of sclerae and cartilage is characteristic, diagnosis is confirmed by typical changes of spinal X-rays and the finding of homogentisic acid in urine samples. We describe a case of a 53 year old female patient with ochronosis and a second diagnosis of RA.
    Notes: Zusammenfassung Die Ochronose ist eine seltene, autosomal rezessiv vererbte Störung des Tyrosinabbaus. Ihre Symptome manifestieren sich überwiegend am Bewegungsapparat. Entzündungsschübe insbesondere an den großen Gelenken können eine Chronische Polyarthritis (CP) vortäuschen. Charakteristisch sind bräunliche Verfärbungen der Skleren und Knorpel, die Diagnose kann dann durch typische Röntgenveränderungen der Wirbelsäule und den Nachweis von Homogentisinsäure im Urin gesichert werden. Wir beschreiben den Fall einer 53-jährigen Patientin mit Ochronose und einer zusätzlichen CP.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 449-450 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Pollen analysis is well established in palaeogeographical research,, but it remains an underused resource in forensic science,. So far it has been used to investigate only one reported case of murder, but has not to our knowledge been used to determine the time of death. We examined a common ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 35-38 
    ISSN: 1433-0474
    Keywords: SchlüsselwörterÄtherische Öle ; Headspace-CG/MS ; Tötungsversuch ; Key words Volatile oils ; Eucalyptus ; Headspace-GC/MS ; Homicidal attempt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Case: A newborn infant was treated in hospital because of suspected pneumonia and renal insufficiency at the third day post partum. Seven days later, shortly after having been nursed by her mother, the newborn vomited an eucalyptus oil-smelling liquid, which was collected in a diaper. This liquid and the liquid obtained from a gastrolavage performed immediately afterwards were secured in air-tight bottles. The family of the newborn laid a charge against the hospital for bodily harm caused by negligence reproaching the hospital for having wilfully given the newborn a toxic substance. Discussion: Only by means of advanced analytical methods (mikroheadspace GC/MS and GC/MS) which permit a subtle separation of mixtures of volatile oils, the reproach against the hospital could be refuted and the suspicion against the mother confirmed. In connection with the clinical picture which is discussed with reference to the relevant literature, and the investigation results of the police, the mother was deprived of the custody of her child, and the child was placed into the custody of the youth welfare office.
    Notes: Zusammenfassung Fall: Berichtet wird über ein Neugeborenes, bei dem in der Klinik am 3. Tag post partum eine plötzliche Verschlechterung des Gesundheitszustands mit Verdacht auf Pneumonie und Niereninsuffizienz auffiel. 7 Tage später erbrach das Neugeborene, kurz nachdem es erstmalig wieder durch die Mutter versorgt worden war, eine stark nach Eukalyptus riechende Flüssigkeit, die in einer Windel aufgefangen wurde. Diese wurde ebenso wie die unmittelbar danach gewonnene Magenspülflüssigkeit in luftdicht schließenden Behältnissen gesichert. Mit dem Vorwurf der vorsätzlichen Beibringung einer toxischen Substanz konfrontiert, erstattete die Familie des Neugeborenen Anzeige gegen die Klinik wegen fahrlässiger Körperverletzung. Diskussion: Nur durch den Einsatz moderner Analysenmethoden (Mikroheadspace-GC/MS und GC/MS) mit der Möglichkeit der subtilen Trennung von Gemischen ätherischer Öle konnte der Vorwurf gegen die Klinik entkräftet und der Verdacht gegen die Mutter bestätigt werden. Im Zusammenhang mit dem klinischen Bild, das im Vergleich zur einschlägigen Literatur diskutiert wird, und den polizeilichen Ermittlungsergebnissen wurde der Mutter das Sorgerecht entzogen und das Kind in die Obhut des Jugendamts entlassen.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The localization of the neural cell adhesion molecule L1 in the male urogenital tract (including seminal vesicles and prostate) of the mouse and bull was investigated using immunocytochemical and immunochemical methods in order to better understand the function of this glycoprotein in non-neural tissues. L1 antibodies labeled non-myelinated nerves in all portions of the urogenital tract investigated. However, L1 immunoreactivity was also found between epithelial cells of several regions of the urogenital system including epididymal tail, deferent duct, ejaculatory duct and seminal vesicles. Some L1 immunoreactivity was also demonstrated between epithelial cells of murine urinary bladder and urethra. The specificity of the immunoreaction was verified by western blots. There was no correlation between L1 expression and proliferating activity as revealed by double immunocytochemistry using various markers of cell proliferation. This unexpected expression of L1 in nonneural tissue is mainly restricted to non-proliferating epithelia of those portions of the urogenital tract that are derived from the Wolffian duct. It is suggested that L1 in these epithelia could enhance the mechanical resistance and reduce transepithelial permeability.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0533
    Keywords: Key words Meningitis ; C5a complement ; Macrophage ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subarachnoidal application of the complement C5a fragment was used to induce acute experimental meningitis in rabbits and rats within 30–60 min. The early stages of the cellular inflammatory response were studied by means of flow cytometry, transmission electron microscopy and immunofluorescence microscopy. Infiltration of polymorphonuclear leukocytes (PMN) into the subarachnoidal space was the earliest event of the inflammatory reaction. By morphological criteria we found that PMN interacted with cells of the mononuclear-macrophage lineage (MML) and the marginal astrocytes via pseudopodia, whereas the pial cells were not involved in early stages of the inflammatory response. The number of invaded MML that were positive with the ED2 marker increased, indicating the hematogenous origin of the immigrating cell population. PMN were found to infiltrate the perivascular space of the marginal arterial vessel segments. This perivascular infiltration was assumed to be the first manifestation of cerebral vasculitis. The intimate association of resident cerebral cells (astrocytes) with invading PMN and MML is suggestive of a transient interaction of these cell types.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Rechtsmedizin 8 (1998), S. 216-218 
    ISSN: 1434-5196
    Keywords: Key words Traffic accident ; Collision pedestrian/car ; Final position of pedestrian ; Schlüsselwörter Verkehrsunfall ; Kollision Fußgänger/ ; Fahrzeug ; Endposition des Fußgängers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es wird über eine ungewöhnliche Unfallvariante berichtet, bei der ein frontal durch einen Pkw angefahrener Fußgänger durch die Frontscheibe schlug und schließlich im vorderen Teil des Fahrgastraumes lag. Neben der hohen Geschwindigkeit (100 km/h und mehr) dürfte vor allem die traumatische Amputation beider Unterschenkel mit dem dadurch verminderten Drehimpuls des Körpers unfalldynamisch die Hauptursache für die Endposition des Fußgängers im Fahrzeug sein. Darüber hinaus wird die geringe Körperhöhe der frontal zum Fahrzeug stehenden Person als begünstigender Faktor angesehen.
    Notes: Abstract We report a rare case of an accident during which a pedestrian was hit by a car and was thrown through the windscreen into the front seat. Apart from the high speed (100 km/h or more) the traumatic amputation of both lower legs and the resulting reduced angular momentum mainly contributed to the final position of the pedestrian in the vehicle. In addition, the low height of the person standing in front of the vehicle is deemed to have been a supporting factor for the course of the accident.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0533
    Keywords: Meningitis ; C5a complement ; Macrophage ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subarachnoidal application of the complement C5a fragment was used to induce acute experimental meningitis in rabbits and rats within 30–60 min. The early stages of the cellular inflammatory response were studied by means of flow cytometry, transmission electron microscopy and immunofluorescence microscopy. Infiltration of polymorphonuclear leukocytes (PMN) into the subarachnoidal space was the earliest event of the inflammatory reaction. By morphological criteria we found that PMN interacted with cells of the mononuclear-macrophage lineage (MML) and the marginal astrocytes via pseudopodia, whereas the pial cells were not involved in early stages of the inflammatory response. The number of invaded MML that were positive with the ED2 marker increased, indicating the hematogenous origin of the immigrating cell population. PMN were found to infiltrate the perivascular space of the marginal arterial vessel segments. This perivascular infiltration was assumed to be the first manifestation of cerebral vasculitis. The intimate association of resident cerebral cells (astrocytes) with invading PMN and MML is suggestive of a transient interaction of these cell types.
    Type of Medium: Electronic Resource
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