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  • 1995-1999  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Lercanidipine (Rec 15/2375): A Novel 1,4-Dihydropyridine Calcium Antagonist for Hypertension (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 15 (1997), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.1997.tb00331.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 50 (1995), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The objectives of this study were to determine: 1) levels of tear eosinophil cationic protein (ECP) in patients with vernal keratoconjunctivitis (VKC); 2) the effect of pharmacologic therapy on ECP release; and 3) the correlation of this mediator with the severity of the disease. Tears were collected from 10 controls and 20 VKC patients before and after therapy for cytologic analysis and ECP measurement by radioimmunoassay. Ocular signs and symptoms were evaluated before tear collection. Mean ECP levels in controls were 7.5 ± 0.4 μg/l, and in VKC patients, 988.3 ± 128 μg/l before therapy (P〈0.001) and 566.3 ± 121 μg/l after therapy (P〈0.005). In dexamethasone (Dex) 0.1%, or cyclosporin A (CsA) 2%, patients (five per group), tear ECP decreased significantly after 7–14 days of treatment. Disodium cromoglycate (DSCG) 4% (five patients) for 14 days did not significantly affect ECP levels. ECP levels were significantly correlated with allergic signs (P〈0.001), symptoms (P〈0.001), and the number of eosinophils in tears (P〈0.005). The results of this study suggest that tear ECP levels accurately reflect the clinical status of VKC patients. The measurement of ECP may prove useful not only in the diagnosis and monitoring of allergic disease, but also as an objective parameter for the evaluation of new antiallergic therapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1995.tb01209.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function (1995)
    Springer
    Neurological sciences 16 (1995), S. 643-646 
    Details
    ISSN: 1590-3478
    Keywords: CSF ; Neurological diseases ; Macromolecules ; GABAA receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Campioni di liquido cefalo-rachidiano di pazienti analizzati per casi di sospette malattie neurologiche sono stati separati nella componente macromolecolare (Peso Molecolare 〉3000 Daltons) ed in quella delle piccole molecole (PM〈3000 Daltons). La c omponente macromolecolare è stata testata per la sua possibile interferenza con l'accumulo di36Cl−, stimolato dal GABA, in “microsacs” della corteccia cerebrale di ratto. Per molte patologie non è stata rilevata alcuna interferenza. Fanno eccezione i pochi (2) casi di morbo di Parkinson; in entrambi i casi vi è una chiara stimolazione dell'attività GABAergica. Quest' ultima indicazione sembra degna di ulteriori indagini.
    Notes: Abstract Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW〉3000 Daltons) and small molecule components (MW〈3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of36Cl− accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230915
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    Paper (German National Licenses)
    Fulltext
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