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  • 1
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical quarterly 48 (1998), S. 470-486 
    ISSN: 0009-8388
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Notes: So far as we can judge from his one completely preserved play and extensive fragments of others, Menander carefully worked out the movements of his characters on and off stage, so as to give an appearance of realism, within certain conventions, and avoid inconsistencies that might distract the audience. Menander's observed practice confirms the famous anecdote, according to which he regarded the construction of a plot as of primary importance, adding the lines as secondary. Thus a character who returns to the stage after an earlier exit always re-enters through the same stage door or wing by which he made his exit; if, for example, he makes his exit in the direction of the market-place, he will be seen by the audience to return from there. Although the ancient evidence is confused, it seems clear, at least, that convention allowed the Athenian audience to regard one wing as leading to the market-place, the other to the country. Similarly, dramatic time is carefully articulated by means of the conventional choral interludes which divide a play into five acts. Some acceleration of dramatic time is possible within an act, but major lapses of dramatic time take place between acts; if a character makes an off-stage trip of some length, for example to the market-place, his exit and re-entry are separated by a choral interlude. Within the act a strict unity of time is maintained and dramatic time (gespielte Zeii) does not greatly exceed performance time (Spielzeii).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical review 47 (1997), S. 420-421 
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Grass and forage science 52 (1997), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: An experiment is reported in which two bunker silos were filled with about 12 t of ryegrass; one was compacted with a surface pressure of 4·1 kPa and the other was not. Both were instrumented to record temperatures and gas compositions during fermentation and feed-out. Cores of silage (100 mm diameter) were removed from the bunkers and subjected to forced aeration in insulated cylinders. Simple mathematical models were used to simulate CO2 leakage from the silos and the associated loss of dry matter, and temperature changes during the forced aeration of silage cores. The leakage of CO2 from the silos, as shown by the fall in CO2 concentration with time, could be described empirically by an exponential equation and could be simulated with a simple mathematical model. Experimental evidence supported the hypothesis that permeation was the main method of gaseous exchange during fermentation and feed-out, but gas mixing by diffusion and/or convection also occurred within the silos during fermentation. Dry-matter losses by aerobic activity during storage of 120–150 d were conservatively estimated to be about 0·3% and 0·9% for the uncompacted and compacted bunkers respectively. These were considered to be lower than those that could be expected in farm silos, because the sealing was likely to be more thorough. The silages were also more stable, when subject to aeration, than others examined in this laboratory, probably because of high contents of acetic, propionic and butyric acids. Simple mathematical models were of value, but greater sophistication is needed (e.g. multi-compartmental models) to deal comprehensively with the heat and gas flows found in the complex biophysical systems of silage.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 20 (1995), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Dundee experimental bald rat (DEBR) undergoes hair loss associated with the development of peri- and intrafollicular mononuclear cell infiltrates, as occurs in human alopecia areata. We studied the effect of orally administered cyclosporin A (10mg/kg; 5 days/week for 7 weeks) on established lesional DEBR rats displaying extensive areas of hair loss. New hairs appeared after 10 days and there was simultaneous regrowth of hair over the whole body with restoration of a full pelt by 5 weeks. Semiquantitative histological examination of flank skin biopsies revealed early reduction of the cellular infiltrate associated with conversion of dystrophic anagen follicles to normal, hair-producing follicles. These results confirm the value of the DEBR model of alopecia areata in evaluating existing and new therapies for this disease in humans.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 91 (1996), S. 127-134 
    ISSN: 1432-0533
    Keywords: Key words Frontal lobe dementia ; Alzheimer's ; disease ; Pick's disease ; Corticobasal degeneration ; Motor neuron disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical features and recent developments in the neuropathology of frontotemporal dementia are reviewed. The five main neurodegenerative disorders that underlie the clinical syndrome of frontotemporal dementia are distinguished using immunohistochemistry with antisera to ubiquitin and tau proteins. Motor neuron disease-type dementia is characterised by ubiquitin-immunoreactive intraneuronal inclusions in cortical layer II and the hippocampal dentate granule cells. A diagnosis of Alzheimer's disease changes is based upon the presence of neurofibrillary tangles, which immunostain with antibodies to tau and ubiquitin, and many associated neuritic plaques. Corticobasal degeneration is diagnosed by the presence of tau-immunoreactive, but ubiquitin-non-reactive intraneuronal inclusions in cortical layer II and the substantia nigra. Pick's disease is restricted to cases with tau- and ubiquitin-immunoreactive spherical cortical intraneuronal inclusions (Pick bodies), best seen in the hippocampal dentate gyrus and frontotemporal cortex. Dementia of frontal type is the preferred term for cases in which no intraneuronal inclusions are seen with antisera to tau and ubiquitin. A practical approach to the pathological diagnosis of frontotemporal dementia and the differential diagnosis of the five disorders using immunohistochemical studies is provided.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Cannabinoids ; Pigeon ; SR141716A ; Drug discrimination ; Startle ; Fixed consecutive number ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse biochemical, physiological and behavioral effects induced by cannabinoid agonists. The present experiments characterized the activity of SR141716A (SR) in behavioral procedures designed to assess its antagonistic and intrinsic effects on unconditioned behavior and on complex learned behaviors. Six adult male pigeons were trained to discriminate injections of 0.56 mg/kg Δ9-tetrahydrocannabinol (Δ9-THC) from vehicle under a two-key, fixed-ratio schedule of food reinforcement. SR (IM) produced a nearly complete blockade of THC-appropriate responding occasioned by the training dose without inducing significant changes in session response rates, but also produced partial substitution for Δ9-THC when administered alone. In another group of pigeons trained under a multiple schedule of signaled and unsignaled fixed consecutive number (FCN) responding, SR had little effect on accuracy, but Δ9-THC produced dose-related decreases in accuracy under both schedule components. SR was also evaluated in acoustic startle procedures in rats. SR produced little effect either on startle amplitude or prepulse inhibition of acoustic startle. In contrast, the potent cannabinomimetic CP-55, 940 produced large decreases in startle responses elicited by 120 dB [A] broad-band noise. These decreases were completely reversed by SR (10 mg/kg, IP). In concurrent measures, SR blocked the hypothermic effect CP-55,940. These results suggest that SR is an effective antagonist of the psychoactive effects of cannabinoids.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Lasers in medical science 13 (1998), S. 73-77 
    ISSN: 1435-604X
    Keywords: Cartilage ; Chondrocyte ; Laser ; Stress relaxation ; Structure alterations ; Thermal and mechanical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract It is difficult to permanently alter the shape of cartilage in a controlled way. In otolaryngology and plastic surgery several procedures are done to alter the shape of cartilage, for example the correction of a deviated nasal septum and surgery for bat ears. The aim of this paper is to study the main parameters which are necessary for the phenomenon of reshaping of cartilage under non-destructive laser radiation. We have measured temperature and stress in cartilage when it is being reshaped with a holmium laser, It has been shown that laser-induced stress relaxation in cartilage takes place when the tissue temperature exceeds 70°C. We have determined the conditions which allow the shape of cartilage to be altered without producing any pronounced alteration to matrix structure or chondrocytes.
    Type of Medium: Electronic Resource
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