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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background We have shown that interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are present in sputum from patients experiencing acute asthma attacks, by eosinophil survival assay. The viability of guinea-pig eosinophils was significantly increased in the presence of such sputum extracts after 3 days' culture, and it was inhibited by the addition of anti-IL-5 and anti-GM-CSF antibodies. However, the contribution of IL-5 to the increase in eosinophil viabihty was less than expected from the values of IL-5 measured by enzyme-linked immunosorbent assay (ELISA). Therefore, we speculated that something in sputum inhibited the function of IL-5.Objective Tratnsforming growth factor-β (TGF-β) was the only cytokine we tested that inhibited the prolongation of survival of guinea-pig eosinophils induced by IL-5. The objective of this study is to detect TGF-β in the same sputum. Methods Guinea-pig eosinophils were cultured with or without anti-TGF-β antibody in the presence of sputum extracts, and the eosinophil viability was counted after 3 days. Measurement of TGF-βl in sputum was performed by ELISA. Results Eosinophil viabilities with and without anti-TGF-β antibody were 79.7 ± 2.9% and 69.0 ± 2.7%, respectively, and the difference between them was statistically significant (P 〈 0.05, n = 9). The concentration of TGF-β1 in the sputum was 21.7 ± 3.3 ng/mL (n = 9).Conclusion These observations suggest that TGF-β is present in sputum from patients with bronchial asthma.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background There are no reports of respiratory epithelial damage induced by immuiioglobulin-stimulated eosinophils.Objective We tried to induce damage to respiratory epithelium by guinea-pig (GP) eosinophils stimulated with guinea-pig IgG (GP-lgG)-coated Sepharose 4B beads. Methods GP tracheal epithelium was cultured together with GP eosinophils that had been collected from the peritoneal cavity, purified on a Percoll gradient, and stimulated with GP-lgG-coated beads (GP eosinophils:beads = 20:1). Damage to the epithelium was observed with an inverted microscope.Results After 24 h of culture with three 106 eosinophils. irregularity of the surface of the epithelium, desquamation. shedding of cilia, and abnormal beating of cilia were observed. This damage was first observed after 12 h of incubation, and was more severe at 24 h. No damage was found when beads coated with human serum albumin (HSA) were used. GP eosinophils stimulated with GP-IgG released significantly more EPO than those stimulated with HSA. at 6 and 24 h. Heparin and eatalase partially inhibited the epithelial damage. O2-production by eosinophils was also enhanced with GP-IgG-coated beads. Conclusion Both granule basic proteins and reactive oxygen radicals may be responsible for epithelial damage, probably via an EPO + H2O2+ halide system. These results confirmed that stimulated eosinophils can damage respiratory epithelium.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 2110-2116 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The development of a submillimeter wave, high-harmonic gyrotron using a 12 T superconducting magnet is described. It has achieved frequencies as high as 636 GHz (corresponding to a wavelength of 472 μm) in second harmonic operation. Many resonances could be obtained as a single mode without competing modes. Typical output power is several hundred watts at both the fundamental and the second harmonic. At low beam currents (Ib∼0.5 A), third harmonic operation has been obtained. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: GYROTRON FU IV, a frequency tunable gyrotron for spectroscopy in the submillimeter wavelength range using a 17 T superconducting magnet, has been designed and constructed. Simulations predict that the gyrotron will emit radiation at high frequencies up to 394 GHz (TE041 cavity mode) at the fundamental of the electron cyclotron frequency, up to 858 GHz (TE091 mode) at the second harmonic and up to 1301 GHz (TE8 11 1 mode) at the third harmonic. Preliminary experimental results have demonstrated operation from 158 to 443 GHz at the fundamental and from 336 to 838 GHz at the second harmonic. Output powers are several hundred watts and efficiencies several percent. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1437-9813
    Keywords: Key words Placenta ; Varix ; Aneurysm ; Infantile hemangioendothelioma ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual vascular anomaly of the placenta and infantile hemangioendothelioma (IH) of the liver is described. The patient was an infant with a low birth weight for dates whose placenta showed markedly dilated and tortuous vessels, mainly venous but some arterial, on the fetal surface. Only one case of such a placental-vessel anomaly and no similar case associated with IH of liver has been described previously, although cutaneous hemangiomas have occasionally been reported to occur with IH.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1617-4623
    Keywords: Key words Silent mutation  ;  FtsH protein  ;   Translation initiation  ;  Colicin tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Among Escherichia coli tolZ mutants tolerant to colicins E2, E3, and D, one, KHI10, had a high frequency of λ lysogenization, like the tolZ21 mutant, but unlike tolZ21 KHI10 grew on nonfermentable carbon sources. The tolZ10 gene of KHI10 was cloned and sequenced, and found to have a silent mutation in the ftsH gene, causing an alteration of a minor codon, CUA, for Leu-5 to a suboptimal codon, CUC. In spite of the change in a minor codon, the amount of the FtsH protein present in mutant cells was much less than that in the parental strain. In vivo transcription of the tolZ10 gene was not decreased relative to the wild-type ftsH gene. Analysis of other silent mutations altering the Leu-5 codon (CUA) to CUG or CUU (optimal and suboptimal codons, respectively) revealed that the decrease in concentration of FtsH was seen only with the CUC (tolZ10) codon. Prediction of the mRNA secondary structure suggested that the change from A to C extends the base pairing region longer by one base pair at the root of the stem structure, thus sequestering the Shine-Dalgarno sequence and decreasing the rate of the translational initiation of FtsH.
    Type of Medium: Electronic Resource
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