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  • 1
    Electronic Resource
    Electronic Resource
    Insulin resistance as a programmed response to fetal undernutrition (1996)
    Springer
    Diabetologia 39 (1996), S. 1119-1122 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400663
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A common mitochondrial DNA variant is associated with insulin resistance in adult life (1998)
    Springer
    Diabetologia 41 (1998), S. 54-58 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin resistance ; mitochondrial DNA ; mitochondrial diabetes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitochondrial DNA is maternally inherited. Mitochondrial DNA mutations could contribute to the excess of maternal over paternal inheritance of non-insulin-dependent diabetes mellitus (NIDDM). We therefore investigated the relationship between this variant, insulin resistance and other risk factors in a cohort which had been well characterised with respect to diabetes. Blood DNA was screened from 251 men born in Hertfordshire 1920–1930 in whom an earlier cohort study had shown that glucose tolerance was inversely related to birthweight. The 16 189 variant (T- 〉 C transition) in the first hypervariable region of mitochondrial DNA was detected using the polymerase chain reaction and restriction digestion. DNA analysis showed that 28 of the 251 men (11 %) had the 16 189 variant. The prevalence of the 16 189 variant increased progressively with fasting insulin concentration (p 〈 0.01). The association was independent of age and body mass index and was present after exclusion of the patients with NIDDM or impaired glucose tolerance. We found that insulin resistance in adult life was associated with the 16 189 variant. This study provides the first evidence that a frequent mitochondrial variant may contribute to the phenotype in patients with a common multifactorial disorder. [Diabetologia (1998) 41: 54–58]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050866
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Insulin resistance as a programmed response to fetal undernutrition (1996)
    Springer
    Diabetologia 39 (1996), S. 1119-1122 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400663
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy (1995)
    Springer
    Diabetologia 38 (1995), S. 1205-1212 
    Details
    ISSN: 1432-0428
    Keywords: Key words31P nuclear magnetic resonance spectroscopy ; skeletal muscle ; glucose metabolism ; fetal growth ; programming.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thinness at birth is associated with insulin resistance and an increased prevalence of non-insulin-dependent diabetes mellitus in adult life. As muscle is an important site of insulin resistance, and because thin babies have reduced muscle mass, thinness at birth may affect muscle structure and function and impair carbohydrate metabolism. We have therefore used 31P magnetic resonance spectroscopy to investigate the bioenergetics of gastrocnemius and flexor digitorum superficialis muscles in 16 normoglycaemic women who had a low (≤ 23 kg/m3) and 9 women who had a high (〉 23 kg/m3) ponderal index at birth. In the flexor digitorum superficialis study anaerobic metabolism was stressed with a constant heavy workload. Low ponderal index subjects fatigued more rapidly (3.3 vs 5.8 min); as phosphocreatine decreased, the accompanying drop in muscle pH was less than in the high ponderal index group. In the first minute of exercise phosphocreatine fell and adenosine diphosphate rose more rapidly (p = 0.04 and 0.03, respectively). Gastrocnemius showed a similar trend late in exercise (this exercise was more oxidative, becoming more anaerobic with increasing workload). These changes were not explained by differences in body composition, muscle mass or blood flow. The findings are consistent with a decreased lactic acid and glycolytic adenosine triphosphate production in the low ponderal index group and suggest the possibility that the mechanisms which control substrate utilisation and metabolism in adult life be programmed during prenatal life. [Diabetologia (1995) 38: 1205–1212]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422370
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy (1995)
    Springer
    Diabetologia 38 (1995), S. 1205-1212 
    Details
    ISSN: 1432-0428
    Keywords: 31P nuclear magnetic resonance spectroscopy ; skeletal muscle ; glucose metabolism ; fetal growth ; programming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thinness at birth is associated with insulin resistance and an increased prevalence of non-insulin-dependent diabetes mellitus in adult life. As muscle is an important site of insulin resistance, and because thin babies have reduced muscle mass, thinness at birth may affect muscle structure and function and impair carbohydrate metabolism. We have therefore used 31P magnetic resonance spectroscopy to investigate the bioenergetics of gastrocnemius and flexor digitorum superficialis muscles in 16 normoglycaemic women who had a low (≤ 23 kg/m3) and 9 women who had a high (〉23 kg/m3) ponderal index at birth. In the flexor digitorum superficialis study anaerobic metabolism was stressed with a constant heavy workload. Low ponderal index subjects fatigued more rapidly (3.3 vs 5.8 min); as phosphocreatine decreased, the accompanying drop in muscle pH was less than in the high ponderal index group. In the first minute of exercise phosphocreatine fell and adenosine diphosphate rose more rapidly (p=0.04 and 0.03, respectively). Gastrocnemius showed a similar trend late in exercise (this exercise was more oxidative, becoming more anaerobic with increasing workload). These changes were not explained by differences in body composition, muscle mass or blood flow. The findings are consistent with a decreased lactic acid and glycolytic adenosine triphosphate production in the low ponderal index group and suggest the possibility that the mechanisms which control substrate utilisation and metabolism in adult life be programmed during prenatal life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422370
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Distress and radiological investigations of the urinary tract in children (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 684-687 
    Details
    ISSN: 1432-1076
    Keywords: Key words Radionuclide imaging ; Radiology ; Psychology ; Emotional ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distress associated with radiological investigations may be related to the information and style of parental explanation given to the child and the parents own coping style. In a questionnaire survey we assessed distress in relation to investigations of the urinary tract using the Groningen Distress Rating Scale and the Utrecht Coping List. We found the micturating cystourethrogram (MCUG) to be significantly more distressing than radionuclide investigations. MCUG distress was adversely correlated with passive and palliative parental coping styles. Results suggested that cognitive coping styles modelled by the parents ameliorated distress on dimercaptosuccinic acid scintigraphy. Conclusion The high level of MCUG associated distress and presence of traumatised children in the MCUG sample, along with the potential for parental contribution to distress reduction, suggests that both children and parents would benefit from more active preparation programmes prior to MCUG testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957153
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Distress and radiological investigations of the urinary tract in children (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 684-687 
    Details
    ISSN: 1432-1076
    Keywords: Radionuclide imaging ; Radiology ; Psychology ; Emotional stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distress associated with radiological investigations may be related to the information and style of parental explanation given to the child and the parents own coping style. In a questionnaire survey we assessed distress in relation to investigations of the urinary tract using the Groningen Distress Rating Scale and the Utrecht Coping List. We found the micturating cystourethrogram (MCUG) to be significantly more distressing than radionuclide investigations. MCUG distress was adversely correlated with passive and palliative parental coping styles. Results suggested that cognitive coping styles modelled by the parents ameliorated distress on dimercaptosuccinic acid scintigraphy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957153
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Characterization and stabilization of fiber-coupled laser diode arrays (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 2905-2909 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have characterized the spectra and performance of an ensemble of 11 fiber-coupled laser diode arrays (LDAs) manufactured by Opto Power Inc. These high-power LDAs operate near 795 nm and are of a type commonly used for spin-exchange optical pumping of noble gases. We find the Opto Power LDAs to vary significantly in output power, spectral width, and other important characteristics, in a manner not correlated with age, operating lifetime, or information supplied by the manufacturer. In addition we have developed a two-loop feedback technique for use with LDAs that stabilizes the Rb magnetization in an optical pumping cell to better than one part in a thousand. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149847
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    C(1)-C(α) Torsion Potential Function and Vibrational Assignments of trans-β-Methylstyrene from S1-S0 Supersonic Jet Fluorescence Spectra (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 4386-4396 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100013a006
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    On Giving Practice its Due – a Reply (1995)
    Cambridge : Cambridge University Press
    Religious studies 31 (1995), S. 121-127 
    Details
    ISSN: 0034-4125
    Source: Cambridge Journals Digital Archives
    Topics: Theology and Religious Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0034412500023350
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    Paper (German National Licenses)
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