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  • 1
    Electronic Resource
    Electronic Resource
    Rat C peptide I and II stimulate glucose utilization in STZ-induced diabetic rats (1999)
    Springer
    Diabetologia 42 (1999), S. 958-964 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin action ; diabetes mellitus ; euglycaemic clamp ; C peptide ; nitric oxide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims. To study the effects of physiological concentrations of rat proinsulin C peptide I and II, respectively, on whole body glucose utilization in streptozotocin diabetic and healthy rats. Methods. A sequential insulin clamp procedure was used (insulin infusion rates 3.0 and 30.0 mU · kg–1· min–1) in awake animals. C-peptide infusion rates were 0.05 and 0.5 nmol · kg–1· min–1. Blood glucose was clamped at 7.7 ± 0.3 mmol/l in the diabetic rats and at 3.9 ± 0.1 mmol/l in the healthy rats. Results. In diabetic rats infused at lower rates of C peptide and insulin, glucose utilization increased by 79–90 % (p 〈 0.001) compared with diabetic animals infused with saline and insulin. Increasing the rate of C-peptide infusion tenfold did not elicit a statistically significant further increase in glucose utilization. C peptide I and II exerted similar effects. The metabolic clearance rate for glucose in the diabetic animals infused with C peptide was not different from that of the healthy rats. During high-dose insulin infusion (30.0 mU · kg–1· min–1) glucose utilization increased considerably and no statistically significant C-peptide effects were observed. About 85 % of the increase in glucose utilization induced by C peptide could be blocked by treatment with N-monomethyl-l-arginine. Conclusions/interpretation. Physiological concentrations of homologous C peptide stimulate whole body glucose utilization in diabetic but not in healthy rats. C peptide I and II elicit similar effects. The influence of C peptide on glucose utilization may be mediated by nitric oxide. [Diabetologia (1999) 42: 958–964]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051254
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  • 2
    Electronic Resource
    Electronic Resource
    Loss of test cells leads to the formation of new tunic surface cells and abnormal metamorphosis in larvae of Ciona intestinalis (Chordata, Ascidiacea) (1999)
    Springer
    Development genes and evolution 209 (1999), S. 592-600 
    Details
    ISSN: 1432-041X
    Keywords: Key words Test cell ; Demembranated larva ; Metamorphosis ; Lectin ; Ascidian
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The larvae of the ascidian Ciona intestinalis from which the chorion with the test cells and follicle cells were removed developed normally without the test cells until the early tailbud stage. A number of round-shaped cells morphologically similar to the test cells but with different lectin affinities and autofluorescence, then appeared on the neck region of the demembranated embryos. The new cells had three different types: round, particulate, and granular, and these cells increased in number after the late tailbud stage. The morphology of the adhesive papillae, tunic layers and epidermis of the demembranated larvae was similar to that of control larvae; however, the affinity to lectins was different in the swimming period. Control larvae attached to the substratum after the swimming period, resorbed the tail completely and underwent rotation of the visceral organs. Conversely, rotation occurred before completion of tail resorption in the demembranated larvae. Furthermore, the metamorphic events progressed more slowly in the demembranated larvae. These results suggest that the test cells play important roles in normal development and morphogenesis of ascidian larvae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050293
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  • 3
    Electronic Resource
    Electronic Resource
    Diagnostic value of atypical lymphocytes in cerebrospinal fluid from adults with enteroviral meningitis (1998)
    Springer
    Journal of neurology 245 (1998), S. 598-602 
    Details
    ISSN: 1432-1459
    Keywords: Key words Atypical lymphocyte ; Cerebrospinal fluid ; Cytology ; Enterovirus ; Meningitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have noted two morphologically distinct types of atypical lymphocytes (AL) in the cerebrospinal fluid (CSF) of adult patients with meningitis: one, which we designate type-I AL, with multilobulated nuclei resembling those of the abnormal cells in adult T-cell leukaemia (ATL); and another, type-II AL, characterized by large lymphocytes with basophilic cytoplasm and nuclei containing coarse chromatin. Type-I AL were detected in 25 of 39 patients (64%) with enteroviral and in 11 of 109 (11%) with aseptic meningitis presumed to be caused by other viruses, but not in meningitis resulting from Cryptococcus neoformans (n = 14), Mycobacterium tuberculosis (n = 19) or acute bacterial infection (n = 49). Type-I AL were not seen in herpes zoster (n = 15) aseptic meningeal reactions (n = 15), or in leptomeningeal carcinomatosis (n = 14). Type-II AL were often present in meningitis of various aetiologies and in aseptic meningeal reactions, but not in leptomeningeal carcinomatosis. The presence of type-I AL in the CSF was found to be indicative of enteroviral meningitis with the highest predictive value (69%), while type-II AL had a lower diagnostic positive predictive value in meningitis of the five aetiologies above. Type-I AL immunostained for CD4, while type-II AL were stained for CD8. The presence of type-I AL in CSF strongly suggests enteroviral meningitis, which warrants careful follow-up without antifungal, antituberculous or antibacterial agents. However, type-I AL, which are likely to be virally transformed lymphocytes, must be distinguished from ATL cells, which frequently involve the meninges.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050252
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity (1995)
    Springer
    The journal of membrane biology 144 (1995), S. 167-176 
    Details
    ISSN: 1432-1424
    Keywords: Optical monitoring ; Voltage-sensitive dyes ; Merocyanine-rhodanines ; Embryonic neural activity ; Embryonic nervous tissues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract To evaluate the suitability of a variety of fast voltage-sensitive dyes for optical recording of rapid transmembrane potential activity in the embryonic nervous system, we screened over twenty dyes, including several newly synthesized probes, in three different embryonic neural preparations: cervical vagus nerve bundle, nodose ganglion, and brainstem from 7-day old chick embryos. Measurements of voltage-related optical signals were made using a multiple-site optical recordingsystem. Signal size, signal-to-noise ratio, photobleaching, and phototoxicity were examined. Several promising new merocyanine-rhodanine dyes for embryonic nervous systems were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232802
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of Voltage-Sensitive Dyes for Long-Term Recording of Neural Activity in the Hippocampus (1999)
    Springer
    The journal of membrane biology 172 (1999), S. 145-157 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Optical recording — Voltage-sensitive dye — Dye screening — Merocyanine-rhodanine — Hippocampal slice — Long-term potentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. We searched for an optimal voltage-sensitive dye for optical measurements of neural activity in the hippocampal slice by evaluating several merocyanine-rhodanine and oxonol dyes. The wavelength dependence (action spectra), pharmacological effects of staining, signal size, signal-to-noise ratio, and the utility of the dyes for long-term continuous recording were examined for four merocyanine-rhodanine dyes (NK2761, NK2776, NK3224 and NK3225), which had been reported to be optimal in embryonic nervous systems, and for two oxonol dyes (NK3630 (RH482) and NK3041 (RH155)), which have been among the most popular potentiometric probes for the hippocampal slice preparation. NK2761, NK3224 and NK3225 provided large signal-to-noise ratios, and proved to be useful for optical recordings lasting several hours. NK3630 was most suitable for long-term recording, although the signal-to-noise ratio was slightly inferior to that of the merocyanine-rhodanines. Using NK3630 (RH482) on the hippocampal slice preparation, we demonstrate here that long-term potentiation can be monitored stably for more than 8 hr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900592
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  • 6
    Electronic Resource
    Electronic Resource
    Superplastic Deformation Mechanisms of Monolithic Intermetallics (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 304-306 (Feb. 1999), p. 147-154 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.304-306.147.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Leupeptin Causes an Accumulation of Lipofuscin-Like Substances and Other Signs of Aging in Kidneys of Young Rats: Further Evidence for the Protease Inhibitor Model of Aging (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 786 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb39048.x
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  • 8
    Electronic Resource
    Electronic Resource
    An increased ratio of interleukin-1 receptor antagonist to interleukin-1α in inflammatory skin diseases (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 7 (1998), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: IL-1 receptor antagonist (IL-1ra) is a cytokine that competitively binds the IL-1 receptor to antagonize IL-1 activity without any agonist function. Previous experiments indicated that the ratio of IL-1ra to IL-1α in the normal stratum corneum (SC) was much higher in the sunexposed face than in the sun-protected area, upper arms. It was also reported by another laboratory that IL-1ra is increased in the lesional skin of psoriatic patients. This study was designed to measure the contents of IL-1α and IL-1ra in non-lesional and pathological SC obtained from inflammatory skin diseases including psoriasis and non-psoriatic dermatoses such as atopic dermatitis. The SC materials were obtained with a noninvasive tape-stripping method. Their soluble fractions were prepared and assayed for IL-1α and IL-1ra by enzyme-linked immunosorbent assays. As a result we confirmed the previous findings that the ratio of IL-1ra to IL-1α in the normal SC was much higher in the face than in the sun-protected sites, the trunk as well as extremities. Next, we found that IL-1α contents were significantly reduced in the SC samples obtained from inflammatory skin regardless of whether their IL-1ra contents increased or unchanged. Moreover, we noted that an increased ratio of IL-1ra to IL-1α in the SC was not specific to psoriasis, but was also found in other inflammatory skin diseases including atopic dermatitis. This ratio was found to become lower after successful treatment of these skin lesions with topical glucocorticoids. We conclude from these observations that the increased ratio of IL-1ra to IL-1α in the SC is a non-specific phenomenon that can occur in any inflammatory skin diseases regardless of the inflammatory pattern, probably reflecting a skin regulation process against various kinds of inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1998.tb00332.x
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  • 9
    Electronic Resource
    Electronic Resource
    Far-wing excitation study on the transit region of Hg 3P1→3P0 intramultiplet process in collisions with N2 and CO (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 7341-7350 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Laser-pump and probe approach has been applied to the far wings of Hg 3P1−1S0 resonance line broadened by collisions with N2 and CO to measure excitation spectra for the formation of Hg(6 3P0) and Hg(6 3P1). The excitation spectra are highly asymmetric with the red wing being much more extended than the blue wing. The absolute ratio of nascent yields of Hg 3P0 to 3P1 is determined as a function of the excitation wave number. From these measurements, it is found, commonly for Hg–N2 and Hg–CO systems, that (a) the nascent product ratio, Hg(3P0)/Hg(3P1), grows on the red-wing surface (the A˜ state) with increasing shift, Δν, of the excitation wave number from the line center and finally surpasses unity; (b) the blue-wing surface (the B˜ state) gives mostly Hg(3P1) but has a small chance to give Hg(3P0). Time constant τ0 for the A˜→3P0 process of Hg–N2 is found to change from 17 to 35 ns as the absorption distance Rc between Hg and N2 changes from 3.6 to 4.7 A(ring). From these values of τ0, the transition probability P(A˜→3P0) for a single approach of Hg–N2 to the turning point region is estimated to be about 3.7×10−5. The transition probability P(B˜→3P0) is about 270 times larger than P(A˜→3P0).CO is about 20 times more effective than N2 for the B˜→3P0 process. The Rc dependence of τ0 can be qualitatively explained by the vibrational frequencies of the bound A˜ state and the Franck–Condon factor between the bound A˜ state and the free (repulsive) a˜ state arising from Hg(3P0)+N2. These findings suggest that the direct A˜→a˜ transition is realized in these Hg–N2 and Hg–CO collisions. This gives a remarkable contrast to Hg-atom collisions, where the A→3P0 process is parity-forbidden due to the 0+ and 0− characters of the A and a states, respectively. The coupling mechanisms for the A˜→a˜ and B˜→a˜ transitions in Hg–N2 collisions are discussed in detail. The theoretical estimate of the A˜→a˜ transition probability is made to be compared with the experimental value. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.469046
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  • 10
    Electronic Resource
    Electronic Resource
    Angle-resolved photoelectron and photoion study on the shape resonance in the B 1s ionization region of BF3 (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 2415-2418 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Angle resolved photoelectron and photoion spectroscopy has been used to investigate the e′ shape resonance just above the B 1s ionization threshold of BF3. The B 1s photoelectron asymmetry parameter β is ∼0 in the vicinity of the peak of the shape resonance and increases with increase in photon energy, illustrating good agreement with a theoretical prediction. From the angular distribution measurement of energetic F+ fragments following B 1s photoionization, we have decomposed the photoionization cross section into two components σe′ and σa2″ for the B 1s→e′ parallel and B 1s→a2″ perpendicular transitions and confirmed that the shape resonance is in the e′ symmetry component. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474584
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