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  • 1
    Electronic Resource
    Electronic Resource
    Development of pollen-induced allergic rhinitis with early and late phase nasal blockage in guinea pigs (1998)
    Springer
    Inflammation research 47 (1998), S. 369-374 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Allergic rhinitis — Nasal blockage — Sneeze — Pollen — Airway resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Development of nasal blockage and sneezing during repeated inhalation challenges with Japanese cedar pollens was evaluated in guinea pigs.¶Subjects: Male Hartley guinea pigs.¶Treatment: Guinea pigs were sensitized by intranasal instillation of cedar pollen extracts + Al(OH)3 2 times a day for 7 days. The animal was then forced to inhale the pollens for challenge, which was restrictively trapped in the upper airways, once a week.¶Methods: Change of specific airway resistance (sRaw), sneezing frequency, and titers of anaphylactic antibodies in the serum were measured after each of the 30 challenges.¶Results: At the first challenge, no obvious increase in sRaw was observed. However, the second and third challenges to the animals caused modest biphasic elevations of sRaw, with peaks at the first and the fourth to sixth hour. At the fourth to tenth challenges, marked elevations of sRaw were observed. However, with repetition of the inhalation challenge, the early and the late responses became almost indistinguishable because of partial overlapping as the responses expanded. All guinea pigs sneezed immediately after each pollen inhalation challenge. Apparent increases of both circulating γ1 and IgE antibodies were seen after the seventh challenge.¶Conclusions: These results indicate that the experimental allergic rhinitis established in the present study can be a valuable model for analyzing the pathogenesis of the disease and developing new therapeutic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050346
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  • 2
    Electronic Resource
    Electronic Resource
    Expulsion of the placenta from the uterus is the principal initiator for collagen degradation in mouse uterus (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 123-125 
    Details
    ISSN: 1420-9071
    Keywords: Placenta ; collagen degradation ; initiator ; uterus ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In unilaterally pregnant mice, collagen degradation in the non-pregnant uterine horn was not initiated by removal of the fetus only but by removal of both the fetus and placenta. The results indicate that expulsion of the placenta from the uterus is a principal factor in the initiation of the process of collagen degradation simultaneously in the whole uterus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929354
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  • 3
    Electronic Resource
    Electronic Resource
    Socioeconomic and behavioural risk factors for mortality of individuals with IDDM in Japan: population-based case-control study (1996)
    Springer
    Diabetologia 39 (1996), S. 710-716 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; mortality ; case-control study ; clinical attendance ; risk factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this population-based, one-to-one matched-pair case-control study was to evaluate the factors concerning the markedly increased risk for dying among Japanese subjects with insulin-dependent diabetes mellitus (IDDM) from a social and behavioural perspective. The study was based on the population-based cohort of IDDM subjects in the Diabetes Epidemiology Research International Mortality Study. We studied 90 cases who died and 90 living control subjects, selected from the rest of the cohort, who were matched for sex, birth year, year of diagnosis and duration of diabetes. Socioeconomic and behavioural status were surveyed through a questionnaire. Conditional logistic regression analyses based on 55 respondent pairs revealed that the better educated patients (year of completing education: odds ratio =0.66) who kept the same physician (number of times a patient changed physician: odds ratio =2.77) and who attended a clinic specializing in diabetes (attendance at university hospital clinic: odds ratio =0.18) injecting insulin several times a day (number of injections, odds ratio =0.31) and more frequently attending the clinic (≥ 12 times per year, odds ratio =0.23) were at substantially lower risk of death. The results begin to profile the patients with the highest risk of dying who could be identified earlier and undergo intervention treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418543
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  • 4
    Electronic Resource
    Electronic Resource
    Socioeconomic and behavioural risk factors for mortality of individuals with IDDM in Japan: population-based case-control study (1996)
    Springer
    Diabetologia 39 (1996), S. 710-716 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus ; mortality ; case-control study ; clinical attendance ; risk factor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this population-based, one-to-one matched-pair case-control study was to evaluate the factors concerning the markedly increased risk for dying among Japanese subjects with insulin-dependent diabetes mellitus (IDDM) from a social and behavioural perspective. The study was based on the population-based cohort of IDDM subjects in the Diabetes Epidemiology Research International Mortality Study. We studied 90 cases who died and 90 living control subjects, selected from the rest of the cohort, who were matched for sex, birth year, year of diagnosis and duration of diabetes. Socioeconomic and behavioural status were surveyed through a questionnaire. Conditional logistic regression analyses based on 55 respondent pairs revealed that the better educated patients (year of completing education: odds ratio = 0.66) who kept the same physician (number of times a patient changed physician: odds ratio = 2.77) and who attended a clinic specializing in diabetes (attendance at university hospital clinic: odds ratio = 0.18) injecting insulin several times a day (number of injections, odds ratio = 0.31) and more frequently attending the clinic (≥ 12 times per year, odds ratio = 0.23) were at substantially lower risk of death. The results begin to profile the patients with the highest risk of dying who could be identified earlier and undergo intervention treatment. [Diabetologia (1996) 39: 710–716]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418543
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  • 5
    Electronic Resource
    Electronic Resource
    Geographic variation in mortality among individuals with youth-onset diabetes mellitus across the world (1997)
    Springer
    Diabetologia 40 (1997), S. 212-216 
    Details
    ISSN: 1432-0428
    Keywords: Keywords IDDM ; mortality ; incidence ; epidemiology ; life expectancy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to evaluate the geographic variation in mortality among individuals with youth-onset insulin-dependent diabetes mellitus (IDDM) across the world. The study was based on the currently available IDDM incidence and mortality data. Mortality data for diabetes in the 0–24 year age group were obtained from World Health Organization (WHO) statistics. The mortality rates were adjusted for the frequency of occurrence of IDDM by dividing the mortality rates by the IDDM incidence rates which were obtained from the WHO DiaMond project. There was a more than 10-fold geographic variation in mortality between the developed countries and Eastern European populations. The areas with the highest mortality rates were located in Japan, Eastern Europe and Russia. The areas having the best outcome associated with IDDM were Northern Europe, Central Europe, and Canada. An ecological study demonstrated a relationship between the incidence-adjusted mortality (estimated case-fatality) with IDDM incidence itself (Spearman's correlation coefficient = –0.45) as well as infant mortality and life expectancy at birth. These data demonstrated the possibility of an enormous geographic variation in mortality of youth-onset diabetic patients even in developed countries. It is important to note that these excess deaths are potentially preventable. The ecological study also suggested that the mortality differences may be in part related to overall and diabetes related care. [Diabetologia (1997) 40: 212–216]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050665
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  • 6
    Electronic Resource
    Electronic Resource
    Role of protein in larval swimming and metamorphosis of Bugula neritina (Bryozoa: Cheilostomatida) (1999)
    Springer
    Marine biology 133 (1999), S. 701-707 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Larvae of the marine cheilostomatid bryozoan Bugula neritina (L.) were prevented from settling for 1, 4 and 8 h by mechanical agitation, following which settlement and metamorphosis success were examined. Settlement rates were significantly affected by swimming time, which decreased from 100% after 2 h to 93.7 ± 4.3% after 8 h. Similarly, metamorphosis to the feeding ancestrula was significantly impaired following a swimming time of 8 h, declining from 93.7 ± 4.3% after 1 h to 65.9 ± 7.0% after 8 h. The resultant colonies grew well for the first 3 wk, following which time, growth patterns became erratic. Growth rate was in all cases highly variable, and did not correlate with enforced swimming times. Larval protein composition was examined after 1, 4 and 8 h swimming time, and post-larval composition 1, 2, 5, 24 and 48 h after settlement using sodium-dodecyl-sulphate polyacrylamide-gel electrophoresis (SDS-PAGE). Individual protein content was measured using a densitometer. Larvae did not consume protein during swimming, however a protein measuring 170 kdaltons was consumed during metamorphosis. These results are discussed in the context of larval settlement and energetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050511
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  • 7
    Electronic Resource
    Electronic Resource
    Age-related settlement success by cyprids of the barnacleBalanus amphitrite, with special reference to consumption of cyprid storage protein (1996)
    Springer
    Marine biology 127 (1996), S. 125-130 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Newly molted (0-d-old) cyprids of the barnacleBalanus amphitrite Darwin were prevented from settling for 0 to 14 d at four different temperatures (25, 20, 15 and 5°C treatments). The effect on settlement success of prolonging the cyprid lifetime was evaluated using a nitrilocellulose membrane assay. In addition, protein extract prepared from these cyprids was analyzed using gel electrophoresis to characterize the effect of age on protein content and composition. Settlement success was significantly affected for larvae aged at 25 (P 〈 0.001), 20 (P 〈 0.001) and 15°C (P 〈 0.05), while differences in settlement success between age groups was negligible at 5°C (P = 0.09). Settlement success of cyprids increased with time for up to 3 d (P 〈 0.001, Phase 1), following which settlement success significantly declined (P 〈 0.001, Phase 11). Temperature had no significant effect on settlement in Phase I (P = 0.17), but did enhance the decline in settlement success with age during Phase II (P 〈 0.001). Gel electrophoresis revealed a significant decline in the quantity of the cyprid storage protein CMP (Cyprid Major Protein) with increasing age at 25, 20 and 15°C, but CMP levels remained constant at 5°C. These results suggest that, upon molting to the cyprid stage, larvae may still require a settlement-competence attainment period. This may be achieved by CMP utilization during Phase I, depletion of which during Phase II may be responsible for reduction in settlement success with cyprid age such that remaining CMP stores can no longer support the production of adult structures following settlement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00993652
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  • 8
    Electronic Resource
    Electronic Resource
    Shadowgraphic and emission imaging spectroscopic studies of the laser ablation of graphite in an Ar gas atmosphere (1999)
    Springer
    Applied physics 69 (1999), S. S223 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 61.46.tw; 81.05.Tp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Laser ablation of graphite in an Ar atmosphere at 560 Torr was done using a nanosecond-pulse Nd:YAG laser (1064 nm) at a fluence of 12 J/cm2. Dynamics in the ejection of carbon species and in their confinement near the graphite surface (〈1 mm) due to their numerous collisions with Ar atoms were investigated by shadowgraphy, emission imaging, and emission spectroscopy at delay times of 0.01–100 μs following the laser irradiation. A shock wave was generated, and temporally and spatially dependent emissions from Ar+ and Ar were observed in addition to those from carbon species (C, C+, and C2) and the Bremsstrahlung radiation from a hot plasma. We suggest that the dissipation of the kinetic and thermal energies of the carbon species, their backward motion, and their collisions with each other lead to the formation of clusters and particles through the interaction with Ar atoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003399900216
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  • 9
    Electronic Resource
    Electronic Resource
    B-Cell lymphoma associated with DiGeorge syndrome (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 609-609 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051160
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  • 10
    Electronic Resource
    Electronic Resource
    Notch Strength of Cast Iron under Static and Fatigue Loading (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 4-5 (Oct. 1997), p. 213-218 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.4-5.213.pdf
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