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  • 1
    Electronic Resource
    Electronic Resource
    Intracellular Production of .beta.A4 Amyloid of Alzheimer's Disease: Modulation by Phosphoramidon and Lack of Coupling to the Secretion of the Amyloid Precursor Protein (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 8091-8098 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00025a015
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  • 2
    Electronic Resource
    Electronic Resource
    Cobalt-Catalyzed [2.pi. + 2.pi. + 2.pi.] (Homo-Diels-Alder) and [2.pi. + 2.pi. + 4.pi.] Cycloadditions of Bicyclo[2.2.1]hepta-2,5-dienes (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 6863-6879 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00131a008
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lamellar Phases in Contact with the Lower Consolute Loop of Ionic Surfactant-Water Systems (1995)
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 4202-4204 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00011a006
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Electrode Influence on Transient Thermal Gradients in BaTiO〈sub〉3〈/sub〉 PTC Thermistors (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 132-136 (Apr. 1997), p. 1317-1320 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.132-136.1317.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Multi-instrument probing of the polar ionosphere under steady northward IMF (1999)
    Springer
    Annales geophysicae 18 (1999), S. 90-98 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (polar ionosphere) ; Magnetospheric physics (magnetosphere-ionosphere interactions; polar cap phenomena)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Observations are presented of the polar ionosphere under steady, northward IMF. The measurements, made by six complementary experimental techniques, including radio tomography, all-sky and meridian scanning photometer optical imaging, incoherent and coherent scatter radars and satellite particle detection, reveal plasma parameters consistent with ionospheric signatures of lobe reconnection. The optical green-line footprint of the reconnection site is seen to lie in the sunward plasma convection of the lobe cells. Downstream in the region of softer precipitation the reverse energy dispersion of the incoming ions can be identified. A steep latitudinal density gradient at the equatorward edge of the precipitation identifies the general location of an adiaroic boundary, separating the open field lines of polar lobe cells from the closed field of viscous-driven cells. Enhancements in plasma density to the south of the gradient are interpreted as ionisation being reconfigured as it is thrust against the boundary by the antisunward flow of the viscous cells near noon. Each of the instruments individually provides valuable information on certain aspects of the ionosphere, but the paper demonstrates that taken together the different experiments complement each other to give a consistent and comprehensive picture of the dayside polar ionosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-0090-2
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  • 6
    Electronic Resource
    Electronic Resource
    Interception and dispersal of artificial food falls by scavenging fishes in the abyssal Northeast Atlantic: early-season observations prior to annual deposition of phytodetritus (1997)
    Springer
    Marine biology 128 (1997), S. 329-336 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The hypothesis that the behaviour of deep-sea scavenging fishes is influenced by seasonal input of organic matter from the ocean surface was investigated by observing responses to baits placed on the sea floor at 4800 m depth in the NE Atlantic (48°50′N; 16°30′W) during spring (April 1994). Data from the present study are compared with those from previous studies of the same location made in summer 1989. The first fishes to arrive at baits were the grenadier Coryphaenoides (Nematonurus) armatus and the eel Histiobranchus bathybius, after delays of 28 and 29 min, respectively; these results are not significantly different from those of summer 1989. Similarly, other indices of activity (staying time and swimming speed) showed no evidence of differences between years/seasons. However, the rate of radial dispersal of bait (0.009 m s−1) by C. (N.) armatus was much slower than in all previous studies. A change in the size distribution of C. (N.) armatus to smaller individuals in spring 1994 was also evident. It is suggested that the fish on the abyssal plain may not comprise a steady-state population and that major episodic or seasonal migrations may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050098
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    TOPEX/Poseidon orbit error assessment (1996)
    Springer
    Journal of geodesy 70 (1996), S. 546-553 
    Details
    ISSN: 1432-1394
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract This paper discusses the accuracy of TOPEX/Poseidon orbits computed at Delft University, Section Space Research & Technology (DUT/SSR&T), from several types of tracking data,i.e. SLR, DORIS, and GPS. To quantify the orbit error, three schemes are presented. The first scheme relies on the direct altimeter observations and the covariance of the JGM-2 gravity field. The second scheme is based on crossover difference residuals while the third scheme uses the differences of dynamic orbit solutions with the GPS reduced-dynamic orbit. All three schemes give comparable results and indicate that the radial orbit error of TOPEX/Poseidon is 3–4 cm. From the orbit comparisons with GPS reduced dynamic, both the along-track and cross-track errors of the dynamic orbit solutions were found to be within 10–15 cm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867862
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  • 8
    Electronic Resource
    Electronic Resource
    Investigations with fluorescence in situ hybridization (FISH) demonstrate loss of the telomeres on the reciprocal chromosome in three unbalanced translocations involving chromosome 15 in the Prader-Willi and Angelman syndromes (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 345-349 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two patients with classical features of Angelman syndrome (AS) and one with Prader-Willi syndrome (PWS) had unbalanced reciprocal translocations involving the chromosome 15 proximal long arm and the telomeric region of chromosomes 7, 8 and 10. Fluorescence isitu hybridization (FISH) was used for the detection of chromosome 15(q11-13) deletions (with probes from the PWS/AS region) and to define the involvement of the telomere in the derivative chromosomes (with library probes and telomere-specific probes). The 15(q11-13) region was not deleted in one patient but was deleted in the other two. The telomere on the derivative chromosomes 7, 8 and 10 was deleted in all three cases. Thus, these are true reciprocal translocations in which there has been loss of the small satellited reciprocal chromosome (15) fragment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210421
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  • 9
    Electronic Resource
    Electronic Resource
    Scopolamine increases prehensile force during object manipulation by reducing palmar sweating and decreasing skin friction (1997)
    Springer
    Experimental brain research 114 (1997), S. 578-583 
    Details
    ISSN: 1432-1106
    Keywords: Key words Grasping ; Friction ; Sweat ; Scopolamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this study was to determine whether relatively long-term changes in skin friction induced by a pharmacological blockade of sweat excretion would alter the grip forces applied to objects of a variety of different surface textures and frictions. Five men and three women were asked to lift the vertically mounted armature of a linear motor between the thumb and index finger and to hold it against an opposing force for 2 s. A 1.0-kHz tone indicated to the subject that the manipulandum had been correctly positioned between the upper and lower position limits. The linear motor generated a 2.5-N force tangential to the skin surface simulating an object weighing approximately 250 g. Three different polyamide plastic surfaces (either smooth or etched with 1.0 mm high Braille beads evenly spaced at 2- or 3-mm intervals) contacted the fingers in these experiments. Subjects lifted and held in a precision grip one of the three surfaces for blocks of ten consecutive trials, but the order of presentation of the three different textures was varied to offset the effect of expectancy. On a second block of ten trials the subjects were requested to release the object slowly to measure the ratio of the grip force normal to the grasped surface to the tangential load force at the moment of slip. This ratio or its inverse provided the coefficient of friction or the slip ratio for a particular subject and surface condition. Twelve hours prior to a second recording session all subjects placed transdermal patches of 1.5 mg scopolamine behind each ear to reduce palmar sweating by blocking the muscarinic receptors of exocrine sweat glands. The subjects were re-tested following procedures that were identical to the first session. Scopolamine significantly reduced the friction of the skin on the smooth and 2-mm beaded surfaces, but the friction of the 3-mm beaded texture was unaffected. Scopolamine also caused subjects to increase both the peak and static grip forces for all the textures including the 3-mm beaded surface, suggesting that for two of the three surfaces they were responding to the increased slipperiness of the skin due to reduced sweat production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005666
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  • 10
    Electronic Resource
    Electronic Resource
    The effects of muscimol inactivation of small regions of motor and somatosensory cortex on independent finger movements and force control in the precision grip (1999)
    Springer
    Experimental brain research 128 (1999), S. 31-40 
    Details
    ISSN: 1432-1106
    Keywords: Key words Hand movements ; Monkey ; GABAergic inhibition ; Cortex ; Motor control ; Grip force
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This study investigated the effects of inactivating small regions of the primary somatosensory (SI) and motor (MI) cortex on the control of finger forces in a precision grip. A monkey was trained to grasp and lift a computer-controlled object between the thumb and index finger and to hold it stationary within a narrow position window for 2 s. The grip force applied perpendicular to the object surface, the lifting or load force applied tangentially in the vertical direction, and the vertical displacement were sampled at 100 Hz. Also, the ability of the monkey to extract small pieces of food from narrow wells of a Klüver board was analyzed from video-tape. Preliminary single-unit recordings and microstimulation studies were used to map the extent of the thumb and index-finger representation within SI and MI. Two local injections of 1 µl each (5 µg/µl) of the GABAA-agonist muscimol were used to inactivate the thumb and index region of either the pre- or post-central gyrus. The precision grip was differently affected by muscimol injection into either SI or MI. MI injections produced a deficit in the monkey’s ability to perform independent finger movements and a general weakness in the finger muscles. Whole-hand grasping movements were inappropriately performed in an attempt to grasp either the instrumented object or morsels of food. Although the effect seemed strongest on intrinsic hand muscles, a clear deficit in digit extension was also noted. As a result, the monkey was unable to lift and maintain the object within the position window for the required 2 s, and, over time, the grip force decreased progressively until the animal stopped working. Following SI injections, the most obvious effect was a loss of finger coordination. In grasping, the placement of the fingers on the object was often abnormal and the monkey seemed unable to control the application of prehensile and lifting forces. However, the detailed analysis of forces revealed that a substantial increase in the grip force occurred well before any deficit in the coordination of finger movements was noted. This observation suggests that cutaneous feedback to SI is essential for the fine control of grip forces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050814
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