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  • 1
    Electronic Resource
    Electronic Resource
    Application of the Free Energy Perturbation Method to Human Carbonic Anhydrase II Inhibitors (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 2061-2069 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00012a005
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative FTIR Method for Determination of Mineral Oil Deposited on Plant Leaves (1995)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 43 (1995), S. 2794-2795 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00059a002
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  • 3
    Electronic Resource
    Electronic Resource
    Setting up a Web site - managing the legal risks (1996)
    Bingley : Emerald
    Internet research 6 (1996), S. 24-30 
    Details
    ISSN: 1066-2243
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Computer Science
    Notes: Suggests that with the increasing sophistication and complexity of Web sites, and the prospect of serious business being done through them, a review of the legal aspects of the site should be an integral part of the site design process. Discusses different ways of setting up a Web site, some of the legal consequences that attach to each and some ways of managing the risk of liability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10662249610127300
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  • 4
    Electronic Resource
    Electronic Resource
    The neutrophil oxidative burst in diarrhoea – associated haemolytic uraemic syndrome (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 445-447 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Haemolytic uraemic syndrome ; Neutrophil ; Oxidative burst ; Elastase ; Chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract . Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome (D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques. Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral blood neutrophil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050136
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  • 5
    Electronic Resource
    Electronic Resource
    Complement activation in Henoch-Schönlein purpura (1997)
    Springer
    Pediatric nephrology 11 (1997), S. 477-480 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Henoch-Schönlein purpura ; Complement activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The pathogenetic mechanism underlying Henoch-Schönlein purpura (HSP) is poorly understood. Complement activation has been thought to have a role, but despite the demonstration of complement components in skin and renal biopsy material, serological evidence of complement activation is not convincing. We have assessed complement activation in 64 children with acute HSP. We used an enzyme-linked immunosorbent assay to measure plasma levels of three multimolecular complement activation protein (CAP) complexes: C1r: C1s: C1-inhibitor, C3bP and C5b-9. We found no significant difference between the levels of CAPs in children with acute HSP and a control group of children. This study does not support a role for complement activation in the pathogenesis of HSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050320
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular co-crystals of 2-aminothiazole derivatives (1999)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 758-766 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A series of molecular adducts of 2-aminothiazole derivatives – 2-aminothiazole, 2-amino-2-thiazoline and 2-aminobenzothiazole with the carboxylic-acid-substituted heterocyclics indole-2-carboxylic acid, N-methylpyrrole-2-carboxylic acid and thiophene-2-carboxylic acid – have been prepared and characterized using X-ray powder diffraction and in five cases by single-crystal X-ray diffraction methods. These five compounds are the adducts of 2-amino-2-thiazolium with indole-2-carboxylate [(C3H7N2S)+(C9H6NO2)−], and N-methylpyrrole-2-carboxylate [(C3H7N2S)+-(C6H6NO2)−], 2-aminobenzothiazolium with indole-2-carboxylate [(C7H7N2S)+(C9H6NO2)−], N-methylpyrrole-2-carboxylate [(C7H7N2S)+(C6H6NO2)−] and thiophene-2-carboxylate [(C7H7N2S)+(C5H3O2S)−]. All complexes involve proton transfer, as indicated by IR spectroscopy, while the five crystal structures display similar hydrogen-bonding patterns with the dominant interaction being an R^2_2(8) graph set dimer association between carboxylate groups and the amine/heterocyclic nitrogen sites. Futhermore, in each case a subsiduary interaction between an amino proton and a carboxylate oxygen completes a linear hydrogen-bonded chain. In addition to this, the indole-2-carboxylate molecules in the adduct structure with 2-amino-2-thiazolium form associated dimers which add to the hydrogen-bonding network.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768199003146
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  • 7
    Electronic Resource
    Electronic Resource
    Ion channels of biological membranes: prediction of single channel conductance (1999)
    Springer
    Theoretical chemistry accounts 101 (1999), S. 97-102 
    Details
    ISSN: 1432-2234
    Keywords: Key words: K+ channel ; Glycoporin ; LamB ; ScrY ; Conductance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract. The Poisson-Boltzmann equation was solved numerically for models of the pore regions of the Shaker K+ channel and of two glycoporins (LamB and ScrY) to yield electrostatic potential profiles along the pore axes. From these potential profiles, single-channel current-voltage (I–V) relations were calculated. The importance of a proper treatment of the ionisation state of two rings of aspartate sidechains at the mouth of the K+ channel pore emerged from such calculations. The calculated most likely state, in which only two of the eight aspartate sidechains were deprotonated, yielded better agreement with experimental conductance data. An approximate calculation of single-channel conductances based simply on pore geometry yielded very similar conductance values for the two glycoporins. This differed from an␣experimentally determined conductance ratio of ScrY:LamB=10:1. Preliminary electrostatics calculations appeared to reproduce the observed difference in conductance between the two glycoporins, confirming that single-channel conductance is determined by electrostatic as well as geometric considerations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002140050414
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular complexes of 3-amino-1,2,4-triazole: The crystal structure of 3-amino-1,2,4-triazolium 5-nitrofuran-d2-carboxylate (1999)
    Springer
    Journal of chemical crystallography 29 (1999), S. 67-73 
    Details
    ISSN: 1572-8854
    Keywords: 3-Amino-1,2,4-triazole ; hydrogen bonding ; x-ray crystal structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract 3-Amino-1,2,4-triazolium (3-AT) 5-nitrofuran-2-carboxylate has been prepared and its x-ray crystal structure reported (a = 12.363(3) Å, b = 12.5720(10) Å, c = 12.8550(10) Å, Pbca, orthorhombic, Z = 8, and D c = 1.604 mg m−3). The solid-state packing of this organic acid-base salt consists of a three-dimensional hydrogen-bonded network which exhibits a cage-like repeat unit involving both the N(2)–H and N(4)–H sites of 3-AT. A review of five such structures reveals that in all cases the carboxylate groups interact with either of these sites [and the N(31)H2] and form a R 2 2(8) graph set interaction. Analysis of all 3-AT complexes which form this interaction reveals that the hydrogen-bonding distances between the non-hydrogen atoms are not equal [av. 2.712(5) Å and 2.897(5) Å], with the shorter distance being the interaction between the heterocyclic nitrogen and the corresponding carboxylate oxygen. Furthermore, a review of the interactive modes of all 3-AT adducts has been undertaken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009523431598
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  • 9
    Electronic Resource
    Electronic Resource
    Cytokine gene transcription of human colonic intraepithelial lymphocytes costimulated with epithelial cells bearing HLA-DR and its inhibition by 5-aminosalicylic acid (1996)
    Springer
    Journal of clinical immunology 16 (1996), S. 237-241 
    Details
    ISSN: 1573-2592
    Keywords: Intraepithelial lymphocytes ; cytokine ; reverse transcriptase polymerase chain reaction ; 5-aminosalicylic acid ; inflammatory bowel disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objectives of this study were to activate human colonic intraepithelial lymphocytes at the transcriptional level with HLA-DR+ human colonic epithelial cell line (HT29) in synergy with CD3 monoclonal antibody and to investigate the molecular mechanism for the therapeutic effects of 5-aminosalicylic acid. Lymphocytes were isolated by a mechanical method from resected colon of 22 cases and then cocultured on 10 ng/ml CD3mAb immobilized plates with HT29 which had been induced to express MHC class II molecules by interferonγ. Flow cytometry analysis suggested that the lymphocyte population had a CD4/CD8 ratio similar to that observed in intact tissue sections and that there was no HT29 contamination of the lymphocytes isolated again from cocultured cells. The activation of intraepithelial lymphocytes showed the gene transcription of interferonγ and tumor necrosis factorα, as measured by means of the reverse-transcriptase polymerase chain reaction, and this activation was antagonized by 5-aminosalicylic acid. Thus, epithelial cells bearing HLA-DR are capable of enhancing CD3-induced activation of human colonic intraepithelial lymphocytes and subject to inhibition by 5-aminosalicylic acid, the active moiety of salicylates used in inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541230
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