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  • 1
    Electronic Resource
    Electronic Resource
    High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 24 (1995), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have investigated the correlation between the prevalence of hepatitis C virus (HCV), which is detectable in saliva, and oral cancer and other digestive tract cancers in the Northern Kyushu region of Japan. Anti-HCV antibodies were detected in sera from 24 of the 100 patients with oral cancer (24%, p〈0.05 vs the control group, p〈0.01 vs the stomach cancer group), in 11 of 104 patients with non-malignant diseases receiving dental treatment (the control group, 10.6%), and in 12 of 113 patients with stomach cancer (10.6%). HCV-RNA was detected in sera from 17 of 100 oral cancer patients (17%, p〈0.05 vs the control group) and 4 of 104 patients of the control group (3.9%). These results indicate a high prevalence of HCV infection in oral cancer patients, which warrants a systematic study of etiological associations between oral cancer and HCV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1995.tb01199.x
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  • 2
    Electronic Resource
    Electronic Resource
    Recurrent patterns and prognosis following resection of hepatocellular carcinoma (1995)
    Springer
    Journal of hepato-biliary-pancreatic surgery 2 (1995), S. 156-162 
    Details
    ISSN: 1436-0691
    Keywords: HCC ; recurrent pattern ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report is based on an analysis of the recurrent patterns and post-treatment clinical outcome of 78 patients following hepatectomy for hepatocellular carcinoma (HCC). Patients with a single recurrent tumor (group A;n=41) often had multicentric carcinogenesis (41.7%) and were treated locally; i.e., by re-resection or by percutaneous ethanol injection therapy (PEIT). Many of them (42.9%) followed the “curative pattern,” with good prognosis (70.3% 5-year survival rate). Although 6 of the patients with two or three recurrent tumors (group B;n=19) had multicentric carcinogenesis that could be treated locally, 13 of the 19 followed the “non-curative pattern,” with a poor prognosis after recurrence (14.8% 3-year survival rate after recurrence). The primary tumors of the patients with multiple or infiltrating type (group C;n=18) were advanced and these patients had metastatic recurrence, thereby following the “early death pattern” (58.8%) with a poor prognosis (30% 5-year survival rate). For group C patients, hepatectomy was regarded as part of a multidisciplinary treatment regimen that included aggressive postoperative chemotherapy as a necessary component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348742
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of serum hepatitis A virus antibody response in different courses of hepatitis A virus infection (1996)
    Springer
    Journal of gastroenterology 31 (1996), S. 812-817 
    Details
    ISSN: 1435-5922
    Keywords: hepatitis A virus (HAV) ; antibody to hepatitis A virus (anti-HAV) ; immune adherence hemagglutination (IAHA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in the serum hepatitis A virus anti-body (anti-HAV) response in patients with different clinical courses of HAV infection were examined using immune adherence hemagglutination (IAHA). Anti-HAV was detected 2–6 weeks after the onset of clinical symptoms in patients with the typical course of acute hepatitis A and 1–4 weeks after the onset in those with fulminant hepatitis A. Maximal anti-HAV titers were observed 8–20 weeks after the onset of clinical symptoms, and changes in anti-HAV were similar in the typical and the prolonged course of acute hepatitis A, but maximal antibody titers were higher in the prolonged course. Maximal anti-HAV titers in patients with subclinical HAV infection were significantly lower than titers in patients with the typical and prolonged courses of acute hepatitis A, and in those with fulminant hepatitis A. High titers of anti-HAV remained positive for at least 6 years after infection in patients with clinical infection and for at least 4 years in patients with subclinical infection on follow-up. These findings suggest that the maximum anti-HAV titer correlates with the clinical severity of HAV infection; knowledge of the antibody response should be useful for analyzing the pathogenesis of HAV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358607
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  • 4
    Electronic Resource
    Electronic Resource
    Ligation plus low-volume sclerotherapy for high-risk esophageal varices: Comparisons with ligation therapy or sclerotherapy alone (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 1-5 
    Details
    ISSN: 1435-5922
    Keywords: Key words: esophageal varices ; endoscopic injection variceal sclerotherapy ; endoscopic variceal ligation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Endoscopic variceal ligation therapy (EVL) seems to be a more effective and safer method than endoscopic injection variceal sclerotherapy (EVS) for treating bleeding esophageal varices. However, EVL may entail a higher recurrence rate than EVS. The aim of this study was to examine whether EVL combined with low-dose EVS reduced the recurrence rate compared to treatment with EVL alone and reduced the complication rate compared to treatment with EVS alone. In this prospective study, 59 patients with cirrhosis and high-risk (F2 or F3, red color sign ++ or +++) esophageal varices were enrolled. They were randomly assigned to an EVS group (n = 18), an EVL group (n = 20), and a combination EVL plus low-dose EVS group (n = 21). After the eradication of varices, follow-up endoscopic examinations were carried out for 24 months to determine the recurrence of varices. Complications, e.g., severe dysphagia, fever, renal dysfunction and pleuritis were also evaluated. The recurrence-free rate was significantly lower in the EVL group (60% at 24 months) than in either the EVS group (90%, P 〈 0.05) or the combination group (88%, P 〈 0.05). However, no significant difference was found between the EVS group and the combination group. The complication rate was significantly higher in the EVS group (50%) than in either the EVL group (5%, P 〈 0.01) or the combination group (10%, P 〈 0.01). The combination therapy seems to be useful to improve the benefits achieved with EVL alone and to reduce the harmful effects induced by EVS alone. EVL plus low-volume EVS is advisable in the treatment of high-risk esophageal varices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/00365529850166112
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  • 5
    Electronic Resource
    Electronic Resource
    Role of extravariceal collateral channels in the development of portal-hypertensive gastropathy before and after sclerotherapy (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 142-146 
    Details
    ISSN: 1435-5922
    Keywords: Key words: gastrorenal shunt ; paraesophageal veins ; portal-hypertensive gastropathy ; transhepatic portography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We investigated whether extravariceal collateral pattern contributed to the development of portal-hypertensive gastropathy (PHG) before and after sclerotherapy. Ninety-nine patients with cirrhosis and large esophageal varices were examined in this retrospective study. They were divided into four groups according to transhepatic portographic findings: group A (with neither paraesophageal veins nor gastrorenal shunt; n = 46), group B (with paraesophageal veins; n = 27), group C (with gastrorenal shunt; n = 14), and group D (with paraesophageal veins and gastrorenal shunt; n = 12). To assess PHG, endoscopic examinations were carried out before and 1 week and 1 month after sclerotherapy. The severity of PHG was classified according to a modified McCormack's classification and scored as: absence, 0; mild, 1; severe, 2. There were no significant differences in age, sex, cause of cirrhosis, severity of liver dysfunction, and extent of esophageal varices in the four groups. The PHG score before sclerotherapy was significantly higher in group A than in either group C (P 〈 0.05) or group D patients (P 〈 0.05). The calculated, integrated incremental change in PHG score after sclerotherapy was significantly higher in group A than in group C (P 〈 0.01) and group D patients (P 〈 0.01). Although the integrated change in PHG score was lower in group B than in group A patients, the difference was not significant (P = 0.68). These results suggest that gastrorenal shunt, but not paraesophageal veins, may play a protective role in the development of PHG before and after sclerotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050061
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  • 6
    Electronic Resource
    Electronic Resource
    β1-Integrin mediates cell adhesion, haptotaxis, and chemokinesis of hepatoma cells (1999)
    Springer
    Medical electron microscopy 32 (1999), S. 2-10 
    Details
    ISSN: 1437-773X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007950050002
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  • 7
    Electronic Resource
    Electronic Resource
    Gastric mucus generation in cirrhotic patients with portal hypertension (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 1727-1732 
    Details
    ISSN: 1573-2568
    Keywords: gastric mucus generation ; hexosamine ; liver cirrhosis ; portal hypertension ; tetraprenylacetone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have evaluated gastric mucus generation (study 1) and the effects of tetraprenylacetone on gastric mucus generation (study 2) in cirrhotic patients with portal hypertension. Study 1: Included were 50 noncirrhotics (group A), 25 cirrhotics without portal hypertension (group B), and 25 cirrhotics with portal hypertension (group C). The antrum, corpus, and fundus mucus generation was assessed by hexosamine concentration using biopsy specimens. In groups A and B, the antrum hexosamine concentration was significantly higher compared with the corpus (P〈0.01,P〈0.01) and the fundus (P〈0.01,P〈0.01). In contrast, the hexosamine concentration at each location was similar in group C. Furthermore, the antrum hexosamine concentration of group C was significantly lower compared with that of group A (P〈0.05). In study 2, a double-blind design, 300 mg of tetraprenylacetone was administered for four weeks in 10 cirrhotics with portal hypertension and placebo in 10. The regional hexosamine concentrations were measured before and after drug administration. Placebo administration did not change hexosamine concentration at each location. In contrast, tetraprenylacetone increased the antrum and corpus hexosamine concentration (P〈0.01,P〈0.05), although the fundus concentration did not change. These data suggest that cirrhotics with portal hypertension have reduced gastric antral mucus generation and tetraprenylacetone normalizes this.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088737
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of exercise-induced sympathoadrenergic activation on portal blood flow (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 48-51 
    Details
    ISSN: 1573-2568
    Keywords: portal circulation ; echo Doppler ; plasma noradrenaline concentration ; isotonic exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the relationship between portal venous blood flow and sympathoadrenergic activation after muscle exercise. For this purpose, we used echo Doppler and measured plasma noradrenaline concentration before and after mild (7 metabolic units,N=8) and maximal exercise (14 metabolic units,N=8) in 16 patients without significant disease. Portal venous flow did not change after mild exercise. In contrast, a significant reduction in portal venous flow was observed after maximal exercise (P〈0.01). This was due to reductions in both cross-sectional area of the portal vein (P〈0.01) and portal venous velocity (P〈0.01). Overall, there were significant inverse relationships between the change in plasma noradrenaline concentration and that in cross-sectional area of the portal vein [r=−0.44,P〈0.01 (absolute change);r=−0.47,P〈0.01 (relative change)], that in portal venous velocity (r=−0.63,P〈0.01;r=−0.61,P〈0.01), and that in portal venous flow (r=−0.54,P〈0.01;r=− 0.59,P〈0.01). These results suggest that the reduction in portal venous flow after exercise is related to the degree of sympathoadrenergic activation. This reduction may be due mainly to splanchnic vasoconstriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02063940
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  • 9
    Electronic Resource
    Electronic Resource
    Serum Vascular Endothelial Growth Factor Levels in Various Liver Diseases (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 41-45 
    Details
    ISSN: 1573-2568
    Keywords: VASCULAR ENDOTHELIAL GROWTH FACTOR ; ACUTE HEPATITIS ; FULMINANT HEPATITIS ; VARIOUS LIVER DISEASES ; HEPATOCYTE GROWTH FACTOR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical significance of circulatingvascular endothelial growth factor (VEGF) in patientswith various liver diseases was investigated. Twenty-onepatients with acute hepatitis (AH), 40 with chronic hepatitis (CH), 34 with cirrhosis (LC), 16 withfulminant hepatitis (FH), 10 with primary biliarycirrhosis (PBC), 12 with autoimmune hepatitis (AIH), and120 healthy individuals were included. Serum VEGF levels were measured by a chemiluminescenceenzyme-linked immunosorbent assay. The mean values ofserum VEGF levels in the patients with AH, CH, LC, FH,AIH, PBC, and control were 172.7, 58.0, 44.1, 37.3, 49.7, 74.9, and 65.0 pg/ml, respectively. Thepatients with AH had a level of serum VEGF significantlyhigher than that of the control group (P 〈 0.001).The serum VEGF levels in survivors of FH weresignificantly increased, but not in the nonsurvivors in therecovery phase compared with the levels on admission (P〈 0.05). In the LC patients, serum VEGF levels weresignificantly lower than those of the control group (P 〈 0.05). These findings suggest thatserum VEGF level may be associated with hepatocyteregeneration grade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018863718430
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  • 10
    Electronic Resource
    Electronic Resource
    Cancer Marker: Vascular Endothelial Growth Factor (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1695-1696 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018863131654
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