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  • 1
    Electronic Resource
    Electronic Resource
    Naevus sudoriferus (local eccrine hyperhidrosis) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 9 (1997), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Naevus sudoriferus (local hyperhidrosis) or ephidrosis, in an 8-year-old girl is presented. The symptoms consisted of sweating in an area on the dorsal aspect of the right forearm and had been present for approximately 1 year. Episodes of hyperhidrosis occurred 2–4 times daily. The diagnosis was supported using the starch-iodine sweat test, which delineated the area of sweat dysfunction, The patient was treated topically with aluminium chloride solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1997.tb00518.x
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  • 2
    Electronic Resource
    Electronic Resource
    Follow-up of 151 patients with high-titer U1RNP antibodies (1996)
    Springer
    Clinical rheumatology 15 (1996), S. 254-260 
    Details
    ISSN: 1434-9949
    Keywords: Anti-U1RNP Antibodies ; Mixed Connective Tissue Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed a longitudinal follow-up study of clinical findings in 151 patients with high-titer antibodies against U1 ribonucleoprotein (U1RNP) as measured by haemagglutination. Formal connective tissue disease (CTD) diagnoses were assigned and diagnostic transitions analysed. One-hundred eighteen females and 33 males entered the study; the mean duration of follow-up was 7.1 years. Mean age at entry was 34.7 years; 73% of the patients had early disease (duration 〈2 years). Fifty-six patients (37%) presented with a definite diagnosis, most often mixed connective tissue disease (MCTD, n=40), followed by systemic lupus erythematosus (SLE, n=11) and systemic sclerosis (SSc, n=5). Of 84 patients (56%) presenting with nonspecific symptoms of possible, “undifferentiated” CTD, 58 developed MCTD, 4 SSc and 2 SLE. By the end of the follow-up period, 127 patients had developed a well-defined CTD; final diagnoses were: MCTD (n=97), SLE (n=18), SSc (n=12). We conclude that CTD in the context of high-titer anti-U1RNP antibodies may be transitive and sequential in nature, although the diagnostic criteria for MCTD previously proposed by our group seem to delimit a clinically stable condition in most patients in this subgroup.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229703
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  • 3
    Electronic Resource
    Electronic Resource
    A longitudinal study of pulmonary function in Danish patients with systemic sclerosis (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 384-390 
    Details
    ISSN: 1434-9949
    Keywords: Systemic Sclerosis ; Lung Function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Objective: To determine the types, prevalence and development of respiratory abnormalities in patients with systemic sclerosis (SSc), and to correlate the results with clinical and serological findings. Methods: 176 patients with SSc observed longitudinally were retrospectively included in the study. The change per year of vital capacity (VC), forced expiratory volume in one second/vital capacity (FEV1/VC), diffusing capacity (DLco) and diffusing constant (Kco) of carbon monoxide from the first till the latest pulmonary function test were correlated to clinical and serological findings, including anti-centromere, anti-Scl-70, and antinucleolar antibodies. Results: An isolated reduction of DLco was seen in 47% and a restrictive ventilatory pattern in 25% of the patients. Restrictive ventilatory pattern correlated to pulmonary fibrosis, dyspnoea, a low prevalence (13%) of anti-centromere antibodies and a high prevalence of anti-Scl-70 antibodies (36%). Progression of DLco reduction was related to long disease duration, presence of anti-centromere antibodies and absence of treatment with penicillamine. Conclusion: Pulmonary involvement is common in patients with SSc. The occurrence of different serological abnormalities in patients with restrictive disease and in patients with progressive isolated reduction of DLco, suggests that the two types of pulmonary damage may have different pathogeneses rather than being different stages in the progression of pulmonary damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242456
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  • 4
    Electronic Resource
    Electronic Resource
    A multicentre study of 513 Danish patients with systemic lupus erythematosus. I. Disease manifestations and analyses of clinical subsets (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 468-477 
    Details
    ISSN: 1434-9949
    Keywords: Clinical characteristics ; Cluster analysis ; Nephropathy ; Patient subsets ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A Danish multicentre study was undertaken of the manifestations, infections, thrombotic events, survival and predictive factors of survival in 513 Danish patients with systemic lupus erythematosus (SLE) according to the 1982 classification criteria of the American College of Rheumatology. The mean duration of follow-up was 8.2 years from diagnosis and 12.8 years from first symptom. This paper describes the most common clinical and laboratory manifestations and their relationship to sex and age at the time of onset and diagnosis. Cluster analysis revealed three clinically defined clusters at the time of disease onset. Cluster 1 (57% of patients) consisted of relatively elderly patients without nephropathy or malar rash, but with a high prevalence of discoid lesions. Cluster 2 (18%) consisted of patients with nephropathy, a third of whom also developed serositis and lymphopenia. The patients of the third cluster (25%) all had malar rash and half were photosensitive. Follow-up showed that the patients of cluster 2 developed azotaemia, large proteinuria, arterial hypertension and myositis significantly more often than did the rest of the patients, but the mortality was not increased. The risk of developing renal end-stage disease was highest in men with early-onset disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451282
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  • 5
    Electronic Resource
    Electronic Resource
    A multicentre study of 513 Danish patients with systemic lupus erythematosus. II. Disease mortality and clinical factors of prognostic value (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 478-484 
    Details
    ISSN: 1434-9949
    Keywords: Haemolytic anaemia ; Infections ; Nephropathy ; Predictive factors ; Survival rate ; Systemic lupus erythematosus ; Thromboses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this Danish multicentre study, predictive clinical factors of mortality and survival were calculated for 513 patients with systemic lupus erythematosus (SLE), 122 of whom died within a mean observation period of 8.2 years equalling a mortality rate of 2.9% per year. Survival rates were 97%, 91%, 76% and 64% after 1, 5, 10 and 15 years, respectively. The direct causes of death included SLE (n=35_, infections (n=25), malignancy (n=9), cardiovascular disease (n=32) and other causes (n=21). Uni-and multivariate analyses of survival and mortality were performed for all deaths and for SLE-related deaths. Azotaemia (one-fifth of the patients) was a strong predictor of increased overall and SLE-related mortality, but nephropathy per se (one-half of the patients) and large proteinuria (one-sixth of the patients) were unrelated to survival. Haemolytic anaemia had a significant negative influence on survival related to mortality caused by infections. Diffuse central nervous system disease and myocarditis were related to increased SLE-related mortality, whereas photosensitivity predicted a decreased mortality. Non-fatal infections and thrombotic events predicted a decreased overall survival. Since 1980 the mortality caused by SLE manifestations has decreased significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451283
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